Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"organ at risk"”.
-
Using deep learning generated CBCT contours for on-line dose assessment of prostate SABR treatments
Prostate Stereotactic Ablative Body Radiotherapy (SABR) is a hypofractionated treatment regime where small errors in patient setup have the potential to deliver much higher doses to Organs at Risk (OARs). Inter-fraction variability is reduced by having patients follow a bowel and bladder …
-
Dynamic optimization of fractionation schedules in radiation therapy
In this thesis, we investigate the improvement in treatment effectiveness when dynamically optimizing the fractionation scheme in radiation therapy. In the first part of the thesis, we consider delivering a different dose each day depending on the observed patient anatomy. Given that a fixed …
-
Temporally Feathered Radiation Therapy under Uncertainty
This thesis focuses on radiation therapy planning through novel stochastic optimization models that account for biological heterogeneity and uncertainty in organ-at-risk (OAR) responses. Building on the temporally feathered radiation therapy (TFRT) strategy, we develop a personalized, biologically …
-
An evaluation of theories concerning the health effects of low-dose radiation exposures
The danger of high, acute doses of radiation is well documented, but the effects of low-dose radiation below 100 mSv is still heavily debated. Four theories concerning the effects of lowdose radiation are presented here: supra-linearity, linear-no-threshold (LNT), threshold, and hormesis. The …
-
Modeling Proton Relative Biological Effectiveness Using Monte Carlo Simulations of Microdosimetry
<p>Proton therapy is a radiotherapy modality that can offer a better physical dose distribution when compared to photon radiotherapy by taking advantage of the Bragg peak, a narrow region of rapid energy loss. Proton therapy is also known to offer an enhanced relative biological effectiveness (RBE) …
-
Microdosimetry of radiohalogens in thyroid models
The radiohalogens 123I, 124I, 125I, 131I, and 211At are routinely used or proposed for diagnostic and therapeutic purposes. The different characteristics and application areas of these radioiodine isotopes, together with the possibility to bind them to the same carrier molecule, give many …
-
The Development of Artificial Intelligence-Based to ols For Expert Peer Review of Radiotherapy Treatment Plans
<p>Creating a patient-specific radiation treatment plan is a time-consuming and operator-dependent manual process. The treatment planner adjusts the planning parameters in a trial-and-error fashion in an effort to balance the competing clinical objectives of tumor coverage and normal tissue …
-
Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure
… employed radionuclides and is administered to patients either bound to tumor targeting molecules or as halide to target the thyroid or thyroid cancer. 211At is proposed for radionuclide therapy and preclinical and clinical research on 211At-labeled tumor targeting molecules is on-going. The …
-
Artificial Intelligence (AI)-assisted Cardiotoxicity Management in Lung Cancer Radiotherapy
… remains one of the leading causes of cancer-related mortality worldwide, with radiation therapy being a cornerstone of treatment. However, radiation-induced cardiotoxicity has emerged as a significant long-term complication, impacting patient survival and quality of life. There is increasing …
-
Automated to ols for Contour Review in Radiotherapy
<p>Peer review of organ-at-risk and target volume delineation is essential for patient safety and optimization of treatment outcomes. Peer review makes a substantial impact on patient outcomes, reporting notable rates of plan changes when reviewed and worse survival when patient cases are not …