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Showing 1 to 1 of 1 for “"orally active drug"”.
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Discovery of Quinic Acid Derivatives as Oral Anti-inflammatory Agents
… potency (IC<sub>50</sub>)<sub> </sub>of our most active analog KZ-41 was determined to be 2.83±1.76 mM. Further examination of the structure and activity relationship (SAR) demonstrated that acetylation of the hydroxyl groups reduced NF-κB inhibitory activity. QA amide derivatives lacked …