Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"oral tolerance"”.
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Alergia alimentar - temporalidade X antigenicidade
… Mechanisms involved in the induction of oral tolerance or systemic immunization through the oral rout are still not completely clear. In our previous studies we have shown that when normal mice eat peanuts they become tolerant, and do not develop gut alterations. However, if they are …
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CD4+ T cell response against food antigens in intestinal disease
… dangerous antigens. This process is known as oral tolerance and works very efficiently in healthy individuals, but it can also be disrupted, leading to food intolerances, allergies, celiac disease, or mucosal inflammation in patients with IBD. The adaptive immune system, in particular …
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Intestinal CD4+T Cell Responses to Food
… The intestinal immune system must maintain tolerance to these dietary antigens while still protecting against pathogens and noxious agents. Oral tolerance, a robust mechanism whereby oral administration of antigen results in both local and systemic tolerance to that antigen, is a key …
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Intestinal delivery of heterologous peptides with lactobacilli
Oral administration of autoantigen is a promising method to induce oral tolerance in autoimmune diseases, such as multiple sclerosis. Multiple sclerosis (MS) is a complex disorder of the central nervous system. MS is caused by destruction of several brain antigens in myelin. In order to increase …
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Immunologische Kreuzreaktivität zwischen dem Myelin-Oligodendrozyten-Glykoprotein (MOG) und Butyrophilin (BTN) bei Multipler Sklerose
… involve environmental factors that disrupt self-tolerance to myelin autoantigens but their identity and mode of action are unknown. This study reports that the epitope specificity of autoantibodies to the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in MS, is …
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Bi-directional tumour-host interaction in a murine model
… down regulation of the systemic immune response (Oral Tolerance) to a developing tumour was examined.
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Roles for the E3 Ligase Itch in Immune Response Modulation
… CD4+ T cells. Inadequacies in peripheral tolerance mechanisms were observed based on oral tolerance studies. Itch deficiency was found to directly contribute to the CD4+ bias towards T helper type-2 (Th2) differentiation observed in a mice. Itch modulation of Th2 differentiation occurs in …
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Ricin B Chain-Insulin Fusion Protein Immunomodulation of Type 1 Diabetes
… satisfactory levels of sustained immunological tolerance remains to be accomplished. To restore self-tolerance requires delivery of sufficient amounts of autoantigen to stimulate regulatory T helper cells that function to survey the gut and induce tolerance to consumed antigens such as food. …
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INTERNALIZATION AND IMMUNOGENICITY OF MUCOSALLY-ADMINISTERED SOLUBLE AND PARTICULATE ANTIGENS
… regimens affect mucosal and systemic humoral immune memory remains an insufficiently explored area of research that is critical for vaccine development. In this work, we examined the routes of mucosal antigen internalization and immune responses to mucosal antigens following various …
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Investigation of T cell signalling events regulating immunity and tolerance in vivo
… but also for a state of antigen-specific tolerance to be elicited against harmless antigens. A breakdown in such tolerance can result in the development of a variety of autoimmune diseases including rheumatoid arthritis, Type 1 diabetes, inflammatory bowel disease and coeliac disease. …
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Mechanisms Mediating Asthma Tolerance Induced By Regulatory Dendritic Cells Through CD4+CD25+Foxp3+ T Regulatory Cells
… regulatory T cells (Treg) in the induction of tolerance by DC10 in three levels. We first used the siRNA approach to silence IL-10 gene expression in murine DC10 and we generated DC10 from CD80/86 or H-2Iab gene-KO mice. When used to treat asthmatic mice, the IL-10-silenced and MHCII-deficient …
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The ontogeny and function of intestinal dendritic cells
… in the regualation of CD4+ T cell responses to orally administered innocuous antigen in vivo, with regards to induced Treg (iTreg) differentiation, and the ability to develop oral tolerance to soluble innocuous antigen. Moreover, we addressed the role of IRF4-dependent cDCs in the induction of …
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Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
… BTN/MOG, BTN in the diet would normally induce oral tolerance to the cross-reactive epitope, but this may be broken either by early post-natal exposure to bovine milk products (Miller et al., 1994), gastro-intestinal infections (Hornquist and Lycke, 1993; Weiner 1997) or a combination of both …