Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"oral infection"”.
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Characterization of Deoxycholate-Responsive Genes Utilized by Brucella abortus 2308 During Oral Infection
… hepatosplenomegaly and endocarditis. Brucella infection is most often acquired via inhalation through the respiratory route, or via consumption of unpasteurized dairy products. Although ingestion is a major route of infection, the transcriptional response of B. abortus during oral infection …
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Toll-like receptor expression and signalling in rat trigeminal neurons: Consequences for oral infection and mechanisms of orofacial pain.
The activation of Toll-like receptors (TLRs), expressed by peripheral sensory neurons, represents an innate surveillance function of sensory neurons with important consequences for neuronal function. Despite recent advances, many properties of neuronal TLRs remain poorly understood, particularly …
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The role of the P2X7 receptor in the intestinal inflammatory response to the parasite, Toxoplasma gondii
… local prevalence rates vary widely. Experimental oral infection of susceptible strain s of mice w ith cysts of T. gondii is known to provoke an acute inflammatory response in the intestine, known as toxoplasmic ileitis. The hypothesis tested in this thesis was that the purinergic P2X7 receptor …
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Cardiologists referring patients for periodontal evaluation
… imply that while cardiologists accept the oral-systemic link as associative and relevant to cardiovascular disease, they are not convinced treating periodontal disease or collaborating with dentists will affect health outcomes for their patients. Theories to support this finding are: (a) …
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Modulators of Innate Gut Immunity to Enteric Viral Infections: Murine Norovirus (MNV) as a Model
… by the increased burden of gastrointestinal infections at the extremes of age. In this thesis, using the Murine Norovirus (MNV) oral infection model, I aimed to characterize intestinal mucosal antiviral-responses with specific focus on the role of IELs, the impact of aging and the influence …
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Knowledge, attitudes, practices and challenges regarding oral health among pregnent women in Thulamela Municipality, Vhembe District, Limpopo Province, South Africa
Introduction: Oral health is an integral part of general health and wellbeing. It is of particular interest in pregnant women because they are at increased risk of developing periodontal diseases because of hormone fluctuations that occur during pregnancy. This rise in hormone levels often results …
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Bloodmeal determinants of Zika virus infection of Aedes (Stegomyia) aegypti mosquitoes
… in the blood of viremic mammals influence the infection of Aedes (Stegomyia) spp. mosquitoes with the arboviruses Zika (ZIKV). It has been repeatedly observed in both flaviviruses and alphaviruses that bloodmeals taken from viremic animals are more infectious than artificial bloodmeals. …
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The analysis of Autographa Californica multiple Nucleopolyhedrovirus EXONO (ORF141) function and its role in virus budding
… which are required for the systemic spread or oral infection with the insect host respectively. Little is known about the events of the BV pathway and the mechanism by which nucleocapsids are selected and directed from the nucleus to plasma membrane to form BV. The Autographa californica …
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Association Between Periodontitis and Hyperglycemia and Metabolic Syndrome Components
… inflammatory disease resulting from low-grade oral infection associated with type 2 diabetes mellitus (T2DM). However, its relation including metabolic syndrome and the understanding of biological pathways are under-studied. This study aimed to investigate the relationship between periodontitis …
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The systemic inflammatory response to dental plaque
Introduction: Bacteremia involving oral bacteria and the systemic inflammatory responses are mechanisms that could causally link oral and systemic diseases. Objective: To use an experimental gingivitis model (EGM) in 2 clinical studies to 1) examine the systemic inflammatory responses to dental …
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Fate and Dissemination of Salmonella Reading in Market-age Turkeys at Processing using Oral Gavage Challenge Model
… Reading (SR) in market-age turkeys using an oral gavage challenge model. One hundred twenty-eight-week-old commercial turkey hens were moved from commercial production to research facilities. Upon arrival, a combination of enrofloxacin, 10 mg/kg, and florfenicol, 20 mg/kg, were orally …
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Development and Characterisation of an Immunocompetent Three-Dimensional Oral Mucosal Infection Model
Oral mucosal models are valuable tools for studying oral infection. Existing models have been implemented to study pathogen tissue invasion and resultant damage. These models fail to incorporate an innate immune component such as macrophages, essential for study of host response to infection. …
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Complement evasion strategies of human pathogens - the evolutionary arms race
… contribute to immunopathology. Periodontitis, an oral infection-driven chronic inflammatory disease, has been linked with complement disruption by periodontal bacteria, resulting in inflammation and pathogenesis. The mechanisms of this disruption have partially been revealed, yet in this thesis we …
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Intestinal challenges shape the polarisation of dural meninges memory CD4+ T cells
… Our lab has previously shown that the humoral immune landscape of the dura is intimately associated with that of the intestinal tract, in part reflecting the need of the dura to defend the underlying brain from intestinally derived blood-borne threats. Adaptive CD4<sup>+</sup> T cells have …
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ANTIMICROBIAL PROPERTIES OF PLATELET-RICH PLASMA
… evaluated against microorganisms isolated from oral cavity, such as Candida albicans, Enterococcus faecalis, Pseudomonas aeruginosa, Streptococcus agalactiae and Streptococcus oralis. Blood samples were obtained from healthy donors. The antibacterial activity of P-PRP, was evaluated as the …
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REGULATION AND EXPRESSION OF AMYLOID CURLI IN SALMONELLA INFECTION
… in the mid-17th century from samples of his own oral and fecal microbiota. Leeuwenhoek was limited by the technology of the times; much of his research was spent characterizing what could be seen with a rudimentary microscope. Today, knowledge of biofilms in vitro has grown substantially with …