Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"oral exposure"”.
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Alergia alimentar - temporalidade X antigenicidade
… Mechanisms involved in the induction of oral tolerance or systemic immunization through the oral rout are still not completely clear. In our previous studies we have shown that when normal mice eat peanuts they become tolerant, and do not develop gut alterations. However, if they are …
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Characterizing the pro-inflammatory cytokine response by dendritic cells upon exposure to PrP proteins
… first immune cells to interact with PrPSc after oral exposure. This study looks at the initial exposure of PrPSc on DC activation by measuring TNFα and IL-12 production. There was no significant production of TNFα or IL-12 by bone marrow derived DCs (BMDC) after exposure to PrPSc infected brain …
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Neurological Effects of Low-Level, Chronic Domoic Acid Exposure in a Nonhuman Primate Model
… receptor agonist and neurotoxin, and high-dose exposure to this toxin has been associated with severe illness and permanent memory loss. Although there are strict regulatory limits preventing human exposures greater than 0.075-0.1 mg/kg, recent studies have suggested that repeated and chronic …
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UNDERSTANDING NON-TARGET INSECTICIDE IMPACTS AND OPPORTUNITIES FOR BIOLOGICAL CONTROL IN FIELD CORN
… species is likely less susceptible to RNAi oral exposure in the adult stage. However, RNAi may still pose risks to predators via trophic exposure. My work supports the adoption of current and future corn pest management practices that protect natural enemies, enhancing biological control …
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ASSESSMENT OF POLYCYCLIC AROMATIC HYDROCARBON BIOAVAILABILITY FROM SOIL USING THE JUVENILE SWINE MODEL
… PAH bioavailability from single and repeated exposure to PAHs in different spiked exposure media, assessing PAH bioavailability from soil collected from PAH impacted sites, and assessing biomarkers of exposure and effect following PAH exposure. The effect of exposure duration on …
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Impact of Mosquito Age and Insecticide Exposure on Vector Competence of Aedes albopictus (Diptera: Culicidae) for Zika Virus
… the extent to which sublethal bifenthrin exposure impacted vector competence for ZIKV. We exposed young (6-7 d post-emergence) and old (11-12 d post-emergence) Ae. albopictus to bifenthrin prior to oral exposure to blood meals containing ZIKV (7-day extrinsic incubation period). For this …
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Toxicity assessment of pesticides and biopesticides on wild and managed bees (Hymenoptera, Apoidea), and richness evaluation in mediterranean and tropical agroecosystems
… EOs caused lethal effects after topical and oral exposure to Apis mellifera, Bombus terrestris, Osmia bicornis, and Melipona mondury. Changes in feeding behavior and locomotor alterations caused by exposure to EOs were observed on the stingless bee M. mondury. Commonly used pesticides and …
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An assessment of the biodistribution, persistence, and health impacts of microplastics and nanoplastics in fish
… mm) and nanoplastics (< 1 μm), the risk of these exposures are not understood. A risk assessment for microplastics and nanoplastics is urgently needed, but first more information is required on the biodistribution, persistence, and subsequent health impacts of microplastics and nanoplastics in …
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Heavy Metals in Traditionally Used Fruits Among the Lakota
… US CDC Minimal Risk Levels (MRLs) for chronic oral ingestion, with the possible exception of As in chokecherries and wild rosehips, and U in wild plum and wild rosehips. No US CDC MRL for Pb has been established, because they deem such a standard as inappropriate at the current state of …
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Spatial and statistical analysis approaches to investigate the oral bioaccessibility of potentially toxic elements in Northern Irish soils
… fraction of a soil contaminant. Measuring oral bioaccessibility in vitro can be an acceptable estimate of contaminant oral bioavailability, eliminating the need for in vivo toxicology studies to estimate health risks from oral soil contaminant exposure.<br/><br/>Using soil samples from the …
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Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury
… Infection resulted in increased systemic oral exposure (AUC) of clinically relevant xenobiotics such as verapamil, propranolol, and digoxin. Functionally, these changes were not found dependent on CYP-mediated biotransformation of parent compounds; rather, they appear driven more by …
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Investigations into the role of exogenous estrogenic endocrine disrupting chemicals on immune dysregulation in autoimmune disease
… the growing concern surrounding environmental exposure to EEDCs and immune system modulation. A commonly prescribed EEDC, 17α-ethinyl estradiol, is a synthetic analog of 17β-estradiol (E2), and is also found in many environmental reservoirs of human and animal exposure. Little is known …
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Development of a PBPK-based health risk assessment framework for exposure to cerium, gold, silver and titanium engineered nanoparticles
… ceria nanoparticles is largely dependent on the exposure route and dose. The time courses for various tissues for intravenously (IV) administered 5 nm ceria were well articulated by the model. Biokinetics of the liver and spleen were well articulated for 30 nm ceria whereas biokinetics for other …
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Absorption of Dietary Titanium Dioxide
… Chapters 3 and 4, showing, in the former, that oral exposure to 215.5 mg of fgTiO2 in a hard shell candy (M&M®) did not lead to detectable Ti in the blood of 17 healthy human volunteers. This study had a large control group (n = 26), allowing me to report on the baseline blood levels of Ti in …
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Characterization of Metallic Flavor in Drinking Water: An Interdisciplinary Exploration through Sensory Science, Medicine, Health, and the Environment
… exposed to contaminants through multiple routes; oral intake of trace metal contaminants through drinking water is a likely source. The biochemical mechanism by which humans are able to detect the flavor of strongly metallic agents such as iron has been previously elucidated, but little is known …
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A pharmacokinetic and antimalarial efficacy evaluation of pyridodibemequines and their metabolites
… be directly administered. This was achieved by oral administration of the parent PDBQ compound and subsequent quantification of the parent compound and formation of the major metabolites. In addition, each pre-synthesised major metabolite was orally administered, at the equivalent parent dose, …
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The Diet and Early Childhood Caries (DECC) Study: Validation of a Novel ECC Risk Assessment Tool and Investigation of Diet-Related ECC Risk Factors
… quality of life, and increased risk for both oral and systemic health conditions (Colares and Feitosa, 2003; B. L. Edelstein, Vargas, and D, 2006; Norman Tinanoff and Reisine, 2009). Early identification of risk and prompt, targeted intervention is essential to overcoming the rising rates of …
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Effects of Methylmercury Exposure on the Immune and Neurological Responses of Mice to Toxoplasma gondii Infection
… grains, and seeds are common sources of human exposure to methylmercury. Studies from our laboratory suggest that oral exposure to a single high dose of 20 mg/kg MeHg does not increase the susceptibility to acute toxoplasmosis in CBA/J mice. Therefore, we further investigated endpoints …
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Comparative Immunological Effects of a Natural Estrogen (17β-estradiol) versus a Pharmacologic Synthetic Estrogen (17α-ethinyl estradiol)
Exposure to exogenous estrogens such as synthetic 17α-ethinyl estradiol (EE) occurs via multiple sources (i.e. hormonal contraceptives, environmental contamination, hormone replacement therapy). The natural estrogen, 17β-estradiol (E2), is a well-studied immunomodulatory hormone at both …
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