Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"oral drug delivery"”.
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Oral Drug Delivery -- Molecular Design and Transport Modeling
… process and reduce the time-to-market for new drug developments. This involves billions of dollars of investment due to the large amount of experimentation and validation processes involved. A computational modeling approach, which could explore the design space rapidly, reduce uncertainty and …
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Chemical Modification of Cellulose Esters for Oral Drug Delivery
… investigation for applications including drug delivery, cosmetics, food ingredients, and automobile coating. In oral delivery of poorly water-soluble drugs, amorphous solid dispersion (ASD) formulations have been used, prepared by forming miscible blends of polymers and drugs to inhibit …
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Cellulose Esters and Cellulose Ether Esters for Oral Drug Delivery Systems
… dispersion (ASD) is a popular method to increase drug solubility and consequently poor drug bioavailability. Cellulose ω-carboxyesters were designed and synthesized specifically for ASD preparations in Edgar lab that can meet the ASD expectations such as high Tg, recrystallization prevention and …
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Design and Synthesis of Cellulose Ether Derivatives for Oral Drug Delivery
… (ASD) is an effective method to promote oral delivery of poorly-soluble drugs by dispersing crystalline drugs in a polymer matrix, creating drug supersaturation upon release. Cellulose 𝜔-carboxyesters have been proven to be effective ASD matrices for many different drugs; however, …
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Mixed Polysaccharide Esters for Amorphous Solid Dispersion Oral Drug Delivery Vehicles
… novel polysaccharide mixed ester derivatives for oral drug delivery applications. Cellulose and cellulose esters have been extensively studied and utilized for different applications such as separation membranes, sustainable plastics, and enteric coatings in oral drug delivery carriers. We sought …
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EVALUATION OF HYDROLYTIC ENZYMES IN THE DESIGN OF ORAL DRUG DELIVERY SYSTEMS
… cellulase to improve the release performance of oral modified release dosage forms having as functional polymer hydroxypropyl methylcellulose (HPMC), a hydrophilic cellulose derivative which is substrate of the enzyme itself. Previous examples of the use of enzymes in drug delivery were …
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The design and characterisation of multiparticulate lipidic systems for oral drug delivery
… develop a sustained release hydrophobic matrix drug delivery system utilising extrusion spheronisation. The initial formulation supplied was Sebomin® MR 100mg capsules, an oral modified release commercial product. A technological transfer was undertaken to reproduce the Sebomin® multiparticulate …
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Fabrication of complex oral drug delivery forms by Three Dimensional Printing (tm)
… to the fabrication of complex pharmaceutical drug devices. Limitations of the technology as relating to pharmaceuticals have been addressed and prototype dosage forms have been fabricated. The resolution of the 3DP tablets was found to depend on particle size and liquid migration during …
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Biopharmaceutic and Pharmacokinetic Studies of Sucrose Acetate Isobutyrate as an Excipient for Oral Drug Delivery.
… marketed by another company as a parenteral drug delivery system. The studies reported here focused on investigating SAIB as an excipient, or delivery vehicle, for use in oral delivery of several drugs, including ibuprofen, saquinavir, and clarithromycin. Dissolution experiments were …
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A Dual Approach of Salt Formation and Amorphous Solid Dispersion for Improved Oral Drug Delivery
Poorly water-soluble drugs are characterized by their limited dissolution in the gastrointestinal (GI) tract that causes reduced bioavailability and suboptimal therapeutic outcomes. Drug solubility is a crucial factor that influences the absorption and bioavailability of orally administered drugs. …
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Synthesis and Characterization of Drug-Containing, Polysaccharide-Based Nanoparticles for Applications in Oral Drug Delivery
Amorphous solid dispersions of polysaccharide-drug nanoparticles were produced by a rapid precipitation process known as flash nanoprecipitation and the formulation process and properties of nanoparticles were investigated. In this thesis, several novel cellulose derivatives and a pullulan …
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Development of thin film oral drug delivery devices for use in paediatric and palliative care patient populations
… of unlicensed or off-label medicines in children.Oral liquids and suspensions often contain preservatives and solvents whichmay be harmful to a developing child, and also rely on accuratemeasurement of small volumes to administer the correct dose. In order todetermine the scale of the problem …
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Elucidation of an oral drug delivery mechanism to the mammalian gastrointestinal tract via an engineered T4 phage
… were previously explored as vectors for biologic delivery, yet cellular engineering approaches have traditionally lowered fitness and colonization potential of these microbial factories. As a result, recombinant bacteria are often outcompeted by the native gut flora, requiring high concentrations …
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Synthesis and Structure-property Evaluation of Novel Cellulosic Polymers as Amorphous Solid Dispersion Matrices for Enhanced Oral Drug Delivery
… and bioavailability enhancement of hydrophobic drugs. Cellulose derivatives have strong potential as ASD polymers. We demonstrate herein design, synthesis and structure-property relationship characterization of a new series of organo-soluble cellulose omega-carboxyalkanoates for ASDs, by two …
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Oral drug delivery as an alternative to needle-based injection for large molecules : an assessment of the field & evaluation of high-priority technologies
Oral delivery of large molecules is widely considered the "holy grail" of drug delivery, but attempts to achieve this within the past century have been met with a lack of success, confounded by low bioavailability. Novel mechanisms need to be assessed in order to deliver a clinically relevant …
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Drug delivery during breastfeeding: investigations of formulations and clinical feasibility
… is the optimal nutritional support for infants, oral drug delivery can be challenging. In the past, the concept of drug delivery during breastfeeding was developed as a means to address challenges in low-income countries by facilitating administration using solid dosage forms without the need for …
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Developing methods of selective, location-specific drug delivery in the gastrointestinal tract
Oral drug delivery remains the most commonly used method of drug administration, due to greater patient adherence to the treatment. However, drug efficacy when delivered orally remains suboptimal due to the presence of formidable barriers to drug diffusion in the gastrointestinal (GI) tract and …
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Development of porous delivery systems for oral drug and vaccine administration
… for structural purposes as well as for local drug delivery. Several manufacturing techniques for porous ceramics are reviewed and the drug release from these porous devices is described. Chapter 1 also summarizes the most important aspects of the manufacturing and formulation of conventional …
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Versatility of hot-melt extrusion for dosage form design
… and sustained release formulations for oral drug delivery, using one model drug, mefenamic acid. For solubility enhancement and taste masking formulations, Eudragit EPO was blended with MA in different ratios (20, 25, 30, and 40% of drug loads) and processed by a hot melt extruder to …
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