Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"oral dosage form"”.
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Oral dosage form modifications for older adults: a mixed methods investigation
Introduction: Oral dosage forms (ODFs), particularly solid ODFs, are the most popular and most commonly prescribed of all medication formulations. Older adults are the highest consumers of prescription medication. However, age-related pharmacokinetic, pharmacodynamic and physiological changes can …
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Development of a multi-particulate formulation of viable bacteria for oral and vaginal delivery
… project was to develop multi-particulate dosage forms for delivery of lactic acid bacteria: (a) the development of an oral dosage form containing a high concentration of viable, genetically modified, IL-10 producing Lactococcus lactis (b) the development of a formulation for delivery of …
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The development of chemically engineered pullulan for drug delivery
… pullulan). The foregoing modifications were performed in two steps from the parent pullulan. The first step involved carboxylation of pullulan with sodium chloroacetate yielding carboxymethyl pullulan (CMP). The second step involved the medication of CMP by coupling different amine …
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Pre-clinical development of cyclodextrin-based nanoparticles for oral delivery of protein/peptide drugs-in vitro and in vivo evaluation
Over the past decades, oral protein delivery has become a major research area for pharmaceutical companies. Ideally, once the protein is orally administered, it should remain stable until it reaches the targeted site of absorption in spite of the myriad of factors that could hinder its stability, …
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Trends in Pharmaceutical Product Development 2000-2010
… Hypothetically, this may lead to interesting formulation development strategies. The purpose of the study was to find out, whether any trends in pharmaceutical product development could be detected from data on granted marketing authorisations. Also the lifecycle management approaches the …
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Hydrodynamics investigation of in-vitro dissolution testing
… industry to determine dissolution rate of solid dosage forms. The United States Pharmacopoeia (USP) Dissolution Apparatus II is the device most commonly used for this purpose. Despite its widespread use, dissolution testing remains susceptible to significant error and test failures. Limited …
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Investigating the Hydration and Disintegration Mechanisms of Film-Coated Pharmaceutical Tablets
… pharmaceutical tablet is the most common solid oral dosage form to administer drug or active pharmaceutical ingredient (API) to patients. Tablets are often film-coated with a layer of polymeric material to protect the drug from environmental degradation, facilitate the packaging process, and …
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Solubility enhancement, mechanical properties and taste masking of poorly water soluble compounds by optimizing hot melt extrusion processing
… studying potential delivery routes have explored oral, nasal, dermal, transdermal, transmucosal, pulmonary, and injection routes for their ability to deliver large and small drug molecules. This research project focuses on the oral route, which is generally accepted as an effective delivery route …
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Oral Drug Delivery -- Molecular Design and Transport Modeling
… distribution, absorption and elimination of an oral drug through the gastrointestinal (GI) tract of the human body. In the CAT model, the GI tract is envisioned as a series of compartments, where each compartment is assumed to be a continuous stirred tank reactor (CSTR). We coupled the drug …