Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"oral delivery"”.
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NANOSUSPENSIONS-BASED ORAL DELIVERY PLATFORMS - NANODPS
… e, di conseguenza, della biodisponibilità orale di farmaci scarsamente solubili in acqua, attraverso lo sviluppo di approcci tecnologici per la loro trasformazione in forme farmaceutiche solide destinate alla somministrazione orale. L’obiettivo principale del lavoro è stato quello di …
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Subcutaneous and oral delivery of insulin
… characterize and compare a subcutaneous/oral delivery system for insulin. The effect of various low molecular weight chitosans (LMWCs) on the stability of insulin, using USP HPLC methods, was investigated. Insulin was found to be stable in a polyelectrolyte complex (PEC) consisting of …
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PHARMACOKINETICS AND ORAL DELIVERY OF POLYMETHOXYLATED FLAVONES
… has been identified a major barrier to their oral bioavailability. Subsequently, self-microemulsifying drug delivery system (SMEDDS) was developed and characterized. In vivo evaluation found that the oral delivery of ATE and LTE was substantially enhanced by SMEDDS. Moreover, abundant tissue …
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Development of nanoparticles for oral delivery of insulin
… and poor treatment outcomes. For such diseases, oral drug delivery is the most non-invasive and patient-compliant method of drug administration. Although oral delivery of many small molecule drugs is routine, oral delivery of protein drugs - e.g. insulin presents several challenges including oral …
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Novel carriers for oral delivery of hemophiliac factor IX
… protein replacement therapy using an oral delivery system can both overcome such issues and improve access to treatment in developing countries. Oral delivery is a desirable route for protein therapeutics; however, two main challenges—increasing bioavailability and maintaining protein …
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Surface Modified Solid Lipid Curcumin Nanoparticles For Oral Delivery
… well as pre-clinical trials. However, its poor oral bioavailability due to extremely low aqueous solubility, poor permeability and extensive pre-systemic metabolism has been the major limitation for its use as a chemotherapeutic agent. Solid lipid nanoparticulate formulations have been …
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Engineering Medical Devices to Improve Oral Delivery of Biopharmaceuticals
… significantly challenge the development of oral delivery systems for biologic drugs by compromising their reliable delivery and therapeutic efficacy. While recent advances in oral delivery systems offer improved absorption through tissue penetration, their clinical translation remains …
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Evaluation of the oral delivery of goserelin with Pheroid® technology
… the administration route from subcutaneous to oral may yield great advantages. Goserelin, being a peptide, will face several challenges after oral administration, such as the acidic and enzymatic degradation in the gastrointestinal tract (GI) tract; however, these can be overcome by different …
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Receptor Mediated Oral Delivery Of Bioencapsulated Green Fluorescent Protein Expressed In Transgenic Chloroplasts
… temperature storage and transportation and the delivery through sterile injections. Most of these expenses could be minimized or eliminated when therapeutic proteins are expressed and orally delivered via plant cells. Chloroplasts have the machinery to fold complex and biologically active …
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An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins
… development and among them only 2 are given orally which is Interferon-α and Human growth hormone. Currently, most efforts in both industry and academia are centered around enhancing bioavailability of orally administered TPPs which typically are less than 1%. Oral administration is the …
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Transepithelial transport of nanoparticles targeted to the neonatal Fc receptor for oral delivery applications
… can only be administered by parenteral methods. Oral administration of NPs is highly preferred because of the convenience and compliance by patients, but remains a significant challenge because of the barriers presented by the gastrointestinal tract. In particular, transport across the intestinal …
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Preparation, Characterization and In Vitro Evaluation of Metformin Loaded Hyaluronic Acid Nanoparticles for Oral Delivery
Metformin, an anti-diabetic drug, has a low oral bioavailability (50-60%) due to its poor intestinal absorption. Orally administered mucoadhesive nanoparticles have been shown to interact with the intestinal mucus layer and increase the intestinal permeability of the entrapped drug. The objective …
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Pre-clinical development of cyclodextrin-based nanoparticles for oral delivery of protein/peptide drugs-in vitro and in vivo evaluation
Over the past decades, oral protein delivery has become a major research area for pharmaceutical companies. Ideally, once the protein is orally administered, it should remain stable until it reaches the targeted site of absorption in spite of the myriad of factors that could hinder its stability, …
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Studies investigating the preparation of solid core drug delivery systems for oral delivery of y-globulin via supercritical fluid processing technology
… of novel carrier systems particularly for oral delivery. However, several physicochemical and biological barriers pose as a challenge for the use of biomolecules as oral drug therapies. Solid core drug delivery systems (SCDDS) allow for immobilization of these molecules on a solid surface …
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A Study to Determine Whether Oral Delivery Style, in Presenting Poetry to Students, Significantly Effects the Level of Responsiveness to the Poetry
… one factor in student motivation, lesson delivery style.</p> <p>Four 7th grade classes, two different classes from two different schools, were used, resulting in 69 subjects. Poetry was read to classes with either an aesthetic or a bland delivery style. The behavioral response of the …
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Modification of a DNA Vaccine for Oral Administration in Fish for Aquaculture by Using Non-Microbial Nanoparticles
… protect DNA vaccines such that they could be orally administered. The main objective of the study was to determine if a DNA vaccine could be effectively compounded into an orally administrable formulation with chitosan or polylactide-co-glycolide (PLG). The immune response of hybrid striped …
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Measuring fluency: Temporal variables and pausing patterns in L2 English speech
<p>This paper examines temporal variables and pausing patterns in L2 English speech to investigate fluency as a measurable component of oral proficiency. Fluency can be defined as ‘speed and smoothness of oral delivery’. We can measure the speed of oral delivery through calculating temporal …
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Oral drug delivery as an alternative to needle-based injection for large molecules : an assessment of the field & evaluation of high-priority technologies
Oral delivery of large molecules is widely considered the "holy grail" of drug delivery, but attempts to achieve this within the past century have been met with a lack of success, confounded by low bioavailability. Novel mechanisms need to be assessed in order to deliver a clinically relevant …
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