Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"oral absorption"”.
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Stereoisomeric Prodrugs to Improve Ocular And Oral Absorption of Prednisolone
… (DLP) to improve ocular and oral absorption of prednisolone. These prodrugs have been examined for their interaction with various influx and efflux transporters commonly expressed on corneal and intestinal epithelium. They have been evaluated for their physico-chemical …
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"Pharmacokinetics of Antimicrobial Drugs in the Horse"
Oral antimicrobial drug therapy in horses is limited by a lack of approved formulations, cost, poor bioavailability and adverse effects. Additionally, little is known about the relationship between plasma concentration and tissue concentrations in horses. Therefore, the purpose of this research was …
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Prodrug Approach to Improve Oral and Brain Absorption of HIV Protease Inhibitor, Lopinavir
… associated proteins (MRPs), thereby enhancing oral and brain absorption of lopinavir (LPV). Oral absorption of LPV is severly limited due to low aqueous solubility, intestinal efflux by P-gp and MRP2 and extensive hepatic metabolism (CYP3A4 enzymes). Furthermore, brain LPV absorption is poor …
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IN VITRO ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΓΙΑ ΤΗΝ ΕΚΤΙΜΗΣΗ ΤΗΣ ΒΙΟΔΙΑΘΕΣΙΜΟΤΗΤΑΣ ΜΕ ΒΑΣΗ ΦΥΣΙΚΟΧΗΜΙΚΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΤΩΝ ΦΑΡΜΑΚΩΝ ΚΑΙ ΤΩΝ ΦΑΡΜΑΚΟΤΕΧΝΙΚΩΝ ΜΟΡΦΩΝ
… HAVE BEEN USED, IN ORDER TO ESTIMATE THE ORAL DRUG BIOAVAILABILITY: (A) IN VITRO DISSOLUTION STUDIES IN THREE DIFFERENT SYSTEMS AND IN VIVO BIOAVAILABILITY STUDIES HAVE BEEN PERFORMED. A MONO GENERAL APPROACH FOR IN VITRO-IN VIVO CORRELATIONS OF DISSOLUTION/RELEASE CHARACTERISTICS …
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The Pharmacokinetics of Oxytetracycline in Dogs With Normal and Impaired Renal Function
… dose (11 dogs), single intravenous and oral dose (8 dogs), and multiple oral doses (10 dogs). Animals were replicated in three ranges of percent normal GFR: <25 percent to 49 percent; and (GREATERTHEQ)50 percent. Analyses of plasma OTC concentration-time data demonstrated that …
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Cisplatin cytotoxicity associated with tetracycline resistance determinants in Escherichia coli
… they are inexpensive, safe, demonstrate good oral absorption, and are active against a broad range of bacterial pathogens. Unfortunately, as with most antibiotics, the emergence of microbial resistance to tetracyclines has become a serious problem. Today, most genera examined have …
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Messa a punto di procedure per la semi-sintesi di composti ad attività antitumorale partendo da prodotti naturali. Studi di struttura-attività
… membrane permeability properties, low oral absorption, instability, toxicity, and nontargeting. Herein we report CPT-prodrugs synthesized via ring opening of the lactone moiety as 17-O-acyl camptothecin tripartate conjugates, which bear a polyamine side chain with different …
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Solid Dispersions in Medium-Insoluble Hydrogels for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
… showing promise for tackling solubility related oral bioavailability problems. However, critical parameters important to the design of these ASDs have not been fully elucidated. Thus, the first part of the present study examines design factors for ASDs based on Poly(2-Hydroxyethyl methacrylate) …
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Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
… with an increase in dose. Mean apparent oral clearance (CL/F) is independent of dose and exhibits apparent dose-independent PK behavior over the studied dose range. Oral absorption is highly variable. MS-275 has a 50-fold longer half-life in humans compared to pre-clinical species. PK/PD …
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Mechanism(s) involved in the transport of Fenretinide across Caco-2 monolayers
… activity against various malignancies. After oral administration to animals, femetinide was found to be incompletely absorbed and excreted primarily in feces. The purpose of this study was to investigate the mechanism(s) responsible for the transport of femetinide across Caco-2 cell monolayers …
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Evaluation and enhancement of physical stability of amorphous solid dispersions
… may lead to enhanced bioavailability.[5-7] Oral absorption of APIs depends on two broad, but crucial, events, namely drug solubilization and gastrointestinal permeation.[8] Amorphous solid dispersions have been widely investigated to increase the gastrointestinal permeability, and the roles …
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Nutrient Transporter targeted Delivery of HIV Protease Inhibitors
… efficacy is very limited due to its low oral absorption and bioavailability, which is attributed to extensive cellular efflux mediated by P-gp and first-pass metabolism mediated by CYP3A4. The objective of this dissertation is to develop novel Saq vitamin prodrugs targeting influx …
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FEXOFENADINE AND ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPs): TRANSPORT AND DRUG-DRUG INTERACTIONS
Transporters play a major role in the absorption and disposition of fexofenadine, suggesting this drug could be used as a probe of transporter activity. When fexofenadine was administered in combination with four drugs (buspirone, caffeine, dextromethorphan and losartan) used to probe cytochrome …
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Pharmacokinetics of neostigmine and pyridostigmine in man.
… half-life varied from 56.9 - 100.1 minutes. The oral administration of pyridostigmine alone and of both neostigmine and pyridostigmine in two different groups of myasthenic patients, were also studied. There was a direct linear relation between area, under the plasma concentration - time curve …
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Exploring co-milling as a strategy to improve the dissolution of poorly water-soluble drugs
… fluids remains a critical limitation to the oral absorption of many poorly water-soluble drugs. Co-milling offers a solvent-free and industrially scalable technology to overcome dissolution rate limited absorption. However, its broader application has been constrained by the complexity of …
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Evaluation of ceftiofur sodium as a chemotherapeutic agent in grass carp (Ctenopharyngodon idella)
… intraperitoneal (IP), intramuscular (IM) and oral (PO) at a dosage of 8 mg/kg body weight. Serial blood samples were obtained and plasma samples were analyzed by high performance liquid chromatography for ceftiofur (as measured its metabolite, desfuroylceftiofur (DFC) and DFC-related …
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Investigating the nuclear import protein KPn߀1 as a cancer therapeutic target
… These findings suggest that C60 may have good oral absorption but rapid clearance in living systems. In vivo toxicology studies showed that C60 is tolerable, allowing for its testing in a xenograft nude mouse model. Intraperitoneal injection of C60 selectively inhibited the growth of …
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Improving CNS Delivery of Genistein for the Treatment of Sanfilippo Syndrome
… observed in the CNS of MPS III mouse model. Low oral bioavailability, extensive metabolism, enterohepatic recycling and efflux transporters are few factors that are thought to be responsible for poor penetration of genistein into the brain. We aim to develop strategies to increase genistein …
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In vitro and in silico profiling to assist pharmaceutical development
… For drugs intended to be administered orally water-solubility is a an essential requirement. The development of high-throughput screening and combinatorial chemistry gave a rapid access to a lot of potential drug candidates but as a consequence led to new challenges. On one hand there …
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