Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"optogenetic stimulation"”.
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Strategies for optogenetic stimulation of deep tissue peripheral nerves
Optogenetic technologies have been the subject of great excitement within the scientific community for their ability to demystify complex neurophysiological pathways in the central and peripheral nervous systems. Optogenetics refers to the transduction of mammalian cells with a light-sensitive …
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Electrical and Optogenetic Stimulation of Sympathetic Neurons to Stabilize Blood Pressure after Acute Spinal Cord Injury
… that, when stimulated with epidural electrical stimulation (EES), were able to increase blood pressure in spinal cord injured animals. This region was termed the hemodynamic hotspot. Closed-loop application of EES (eSTIM), showed success in stabilizing blood pressure in the chronic phase of SCI …
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Informing the next generation of auditory midbrain implants, neuronal population dynamics in the auditory cortex and midbrain, and the potentials of optogenetic stimulation
… potential prosthetic sites, in order to optimise stimulation to mimic the area's natural inputs and achieve useful sound perception. Additionally, electrode based devices afford poor spatial resolution, which optogenetics may solve. Simultaneous silicon probe recordings were performed in the …
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Controlling Arrhythmias Using Optogenetic Actuators in Computational Simulations
… discusses the application of light-induced stimulation (optogenetics) in computational models of heart cells (cardiomyocytes), cardiac tissues, and heart chambers to control arrhythmia development. Chapter 1 presents an overview of cardiac anatomy, relevant physiology, and cardiac …
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Advanced technologies for spatio-temporal control of neural circuits using optogenetics
… targeted cells with techniques known as optogenetic stimulation. The combination of optogenetic stimulation methods with electrophysiological recordings and advanced optical imaging is leading to promising approaches aiming at obtaining information on spiking activity, morphology and …
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Optogenetic examination of salt taste in mice
… salt appetite in mice. Experiment 3 showed that optogenetic stimulation of Type I taste receptor cells (TRCs) in transgenic mice could drive consumption of tap water under conditions of salt hunger. The fourth and final experiment assessed whether conditioned taste aversions to sodium would …
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Modulation of hippocampal synaptic transmission by the peptide diazepam binding inhibitor and optogenetic manipulation of astrocytes
… transmission is modulated by both DBI and by optogenetic stimulation of local astrocytes. Chapter 2 investigates the role of DBI in modulating hippocampal synaptic inhibition using a constitutive DBI knockout animal. Chapter 3 continues to use the DBI knockout animals to examine the role of …
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Characterization of spontaneous and evoked activity of mouse embryonic stem cell derived motor neurons using optogenetics and micro electrode array electrophysiology
… a detail investigation of spontaneous and stimulation-evoked electrical activity of developing MN networks. The following work uses multi-electrode array (MEA) electrophysiology and optogenetics to characterize electrical activity of MNs differentiated from mouse embryonic stem (mES) cells. …
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Sensory Coding and Olfactory Integration in Caenorhabditis Elegans
… AIA responses. Instead, AIA responses to optogenetic AWA stimulation had high and variable latencies and low probabilities. AIA responses, when they did occur, had stereotyped on-dynamics to all concentrations of diacetyl tested, to AWA optogenetic stimulation, and to several additional …
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Investigating the Impact of Biochemical and Mechanical Stimuli on Motor Neuron Growth
… Prior research has shown that transcutaneous optogenetic stimulation on grafted engineered tissue can promote reinnervation and angiogensis in a rat volumetric muscle loss model. Our study queried the individual effects of biochemical and mechanical stimuli on neuronal growth to push the field …
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Integrated optical phased arrays for three-dimensional display applications
… through scattering media, underwater LiDAR, optogenetic stimulation, and three-dimensional (3D) displays. Silicon nitride, a CMOS-compatible material that is transparent in the visible spectrum, may be used as the waveguiding material in phased array systems designed for the above …
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Opto-mechanical control of nerve growth
… neurotrophic factors, topography, and electrical stimulation have been proposed to enhance nerve growth. This thesis explores optogenetic neural stimulation as a means to control neurite growth that promises greater cell-type specificity than commonly used electrical stimulation. Using dorsal root …
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Developing a Functional in Vitro Model of the Neuromuscular Interface
… of muscle contraction under electrical and optogenetic stimulation while preserving skeletal muscle tissue integrity and viability. The STAMP approach provides a way to mold hydrogels and the morphology of muscle tissue and will be beneficial for addressing the need for compliant and …
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Optogenetic investigation of normal and pathological rhythms in the hippocampal formation
… be important for memory reconsolidation. Using optogenetic light ramp stimuli in transgenic mice, I found that gradual depolarization of CA1 pyramidal cells (mimicking CA3 sharp-wave input) is sufficient to induce fast gamma and sharp-wave ripple-like high frequency oscillations. I further …
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Habituation and Dishabituation in the Olfactory Bulb: From Neural Responses to Behavior
… prolonged odor presentations using electrical stimulation dishabituated these decreased glomerular odor responses. A novel behavioral investigation paradigm was developed to see how prolonged odor input affects odor salience in awake, behaving mice. Optogenetic stimulation of OB cholinergic …
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Engrams, Neurogenesis, and Forgetting
… gyrus engram ‘tag-and-activate’ strategy. Optogenetic stimulation of dentate gyrus encoding neural ensembles recovered ‘lost’ infant memories even 90 days following the initial learning event. In a process akin to pattern completion, memory recovery was associated with reinstatement of both …
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The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes
… by these neuromodulatory systems. Using optogenetic stimulation or silencing, this thesis aims to investigate the effects of cholinergic and dopaminergic modulation on various hippocamal learning and memory processes. To understand how these neuromodulatory systems modulate hippocampal …
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Muscle Recruitment Mechanism under Optogenetic Neuromodulation
… overall quality of life. Functional electrical stimulation (FES) is the most commonly used technology to restore motion. Although FES is used extensively in the clinic, several drawbacks limit its application for long-term use. FES recruits larger motor units before smaller ones, causing muscles …
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Developmental And Signaling Mechanisms Of Touch Neurons
… activate the Aβ class of LTMRs using optogenetic stimulation using three different mouse lines, Split-Cre, Advillin-FlpO, and Rosa-ReaChR. We then discuss how these tools may be applied to test and define a role for Aβ-LTMRs in pathological pain conditions. Together, this work provides …
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