Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"optoacoustic"”.
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Functional imaging of cancer using Optoacoustic Tomography
… times and limited spatio-temporal resolution. Optoacoustic tomography (OT) is an emerging clinical imaging modality that can provide static images of endogenous haemoglobin concentration and oxygenation. In this work, an integrated framework for quantitative analysis of functional imaging using …
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Clinical Translation of Optoacoustic Imaging in Breast Cancer
Optoacoustic (OA) imaging is an emerging low-cost hybrid imaging investigation/technique currently in clinical feasibility studies for breast cancer diagnosis and staging. The technique applies pulsed light to the tissue of interest where molecules absorb the light photons and generate acoustic …
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Development of Applications and Quantitative Frameworks for Multispectral Optoacoustic Tomography
Page xxxi is misnumbered as page ii.
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Non-invasive Optoacoustic Monitoring of Neonatal Cerebral Venous Oxygen Saturation
… Our project objective is to evaluate a laser optoacoustic device for non-invasive monitoring of cerebral venous oxygen saturation through the open anterior/posterior fontanelles in neonates. Sheep models have shown this device can accurately measure cerebral venous oxygen saturation. We …
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Noninvasive optoacoustic monitoring of blood oxygenation in large blood vessels
… venous blood hemoglobin saturation (SvO2) by optoacoustic probing of blood circulating in the internal jugular vein (IJV). This thesis describes the tests of the optoacoustic system with three different probes in phantoms, in vitro, and in vivo in sheep along with different data processing …
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Engineering functionalized gold nanoparticles as a molecular-specific contrast agent to enhance optoacoustic detection of breast cancer cells
… earlier stages, when complete cure is possible. Optoacoustic tomography (OAT) is a non-invasive imaging modality that can be used to produce an image of the distribution of light absorbing components deep within a turbid medium such as human breast. OAT could potentially be used to image breast …
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The far-ultraviolet spectroscopy of molecules of astrophysical interest
… by Bremsstrahlung processes, with some success. Optoacoustic spectroscopy was considered as a possible technique in the far-ultraviolet with a synchrotron source; its theory was extended to include ionisation and dissociation of molecules. However, optoacoustic experiments attempted were …
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Potentiation of The Immune Checkpoint Blockade Response By Metabolic Modulation Is Predictable Using Molecular Imaging
… and ICB can be predicted using Multispectral Optoacoustic Tomography (MSOT) to measure oxygen saturation (SO2). This effect corresponds to increased intratumoral frequencies of CD8+ and CD4+FoxP3- effector T cells (Teffs) and progenitor Teff subsets. My work shows that molecular imaging can …
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Three-Dimensional Photoacoustic Computed Tomography: Imaging Models and Reconstruction Algorithms
… computed tomography: PACT), also known as optoacoustic tomography, is a rapidly emerging imaging modality that holds great promise for a wide range of biomedical imaging applications. Much effort has been devoted to the investigation of imaging physics and the optimization of experimental …
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Image Reconstruction in Photoacoustic Computed Tomography with Acoustically Heterogeneous Media
… computed tomography (PACT), also known as optoacoustic or thermoacoustic tomography, is a rapidly emerging hybrid imaging modality that combines optical image contrast with ultrasound detection. The majority of currently available PACT image reconstruction algorithms are based on idealized …
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IR laser photochemistry of alkanols and 3,3-dimethyloxetane
… absorbed energy was measured using the optoacoustic (OA) technique. A new method for calibrating the OA cell was developed and is described in full in the thesis. The approach enables calibration to be extended to lower absorption levels (about 200µJ for a signal-to-noise ratio of six) …
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System Optimization and Iterative Image Reconstruction in Photoacoustic Computed Tomography for Breast Imaging
… computed tomography(PACT), also known as optoacoustic tomography (OAT), is an emerging imaging technique that has developed rapidly in recent years. The combination of the high optical contrast and the high acoustic resolution of this hybrid imaging technique makes it a promising candidate …
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MSC DERIVED EV IN REGENERATIVE MEDICINE
… Resonance Imaging (MRI) and MultiSpectral Optoacoustic Tomography (MSOT). Upon evaluating the regenerative effects of the MSC and EV, no difference in cartilage damage could be seen. During bone fracture, MSC and osteoblasts are recruited to the site of injury. Bioglasses have been used …
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Targeted Imaging Agents for Detecting Tumour Cell Death following Therapy
… subsequently by fluorescent, magnetic or optoacoustic probes that allow imaging. As part of this work, we have demonstrated in vitro that a peracetylated cyclopropene mannosamine (Ac4ManNCCp)-modified sugar can be used as a tool for imaging hypersialylation in an advanced colorectal cancer …
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Integrated imaging and circulating biomarkers for the assessment of drug-induced hepatotoxicity
… for determining liver function. Multispectral Optoacoustic Tomography (MSOT) is an imaging modality that facilitates the whole-body imaging of toxicological processes in organs that can be observed in vivo, real-time and with high resolution. MSOT imaging operates in the near-infrared (NIR) …
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Clinical applications of quantitative photoacoustic imaging
Photoacoustic imaging is a medical imaging tool increasingly used in clinical research. It enables the imaging of molecules, including melanin, haemoglobin, lipids, collagen and water deep inside the body, with high resolution and high sensitivity. This molecular information has made it an …
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An Investigation into the Vascular Phenotypes of Breast Patient- Derived Xenografts
Blood vessel networks in tumours are often chaotic, dense and immature resulting in reduced blood perfusion and oxygen delivery, leading to hypoxia (low oxygen levels). Hypoxic tumours are more aggressive, therapy resistant and likely to metastasise, particularly in breast cancer. Equally, hypoxic …
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Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
Neurogenesis, a physiological process by which new neurons are generated from neural stem cells (NSC), occurs throughout life, subverting the old dogma stating to the inability of the adult brain to replace neurons. In the adult mammalian brain, neurogenesis takes place in the subventricular zone …
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Adult hippocampal neurogenesis: traumatic brain injury-induced dysregulation and therapeutic potentials of a novel non-invasive nano-pulsed laser treatment
Neurogenesis, a physiological process by which new neurons are generated from neural stem cells (NSC), occurs throughout life, subverting the old dogma stating to the inability of the adult brain to replace neurons. In the adult mammalian brain, neurogenesis takes place in the subventricular zone …