Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"optical mapping"”.
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Error correcting optical mapping data
Optical Mapping is a unique system that is capable of producing high-resolution, high-throughput genomic map data that gives information about the structure of a genome (Schwartz et al., Science 1993). Recently it has been used for scaffolding contigs and assembly validation for large-scale …
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Development of next-generation near-eye and naked-eye optical display systems
… of the next-generation near-eye and naked-eye optical display systems for virtual reality (VR) and augmented reality (AR) applications using multiple novel designs and techniques, including optical mapping near-eye (OMNI) display, holographic near-eye display, see-through display and naked-eye …
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A Discrete Monolayer Cardiac Tissue Model for Tissue Preparation Specific Modeling
… estimating intracellular conductivities from an optical mapping. First, in the proposed method for modeling a monolayer of cardiac tissue, the factors governing cell shape, cell-to-cell coupling and the degree of cleft space are not constant but rather are treated as spatially random with …
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Development and characterization of fiber-based systems for biomedical imaging
… aspect of biomedical imaging with the use of optical fiber probes across three different disciplines. This includes the design and development of novel fiber optic based techniques and instruments in fields of optical coherence tomography (OCT), bioremediation and optical mapping of cardiac …
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Cardiac Fibrosis and Ventricular Arrhythmogenesis: Unravelling the influence of fibrosis on electrical dysfunction in the development of heart failure
… was also quantified using high resolution optical mapping. Furthermore, a novel optical mapping motion artifact reduction tool was developed using a non-rigid deformation technique. The relatively simple tool was able to recover action potentials (APs) from optical mapping datasets in the …
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Clinical Applications of Genomic Analyses in Prostate Cancer
… potential for whole genome sequencing and optical mapping data to inform treatment selection. Finally, cell-free DNA as a predictor of response to novel treatments is explored in Chapter 5. Overall this work assesses the potential for DNA sequencing in prostate cancer to impact patient …
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The electrophysiology of the atrioventricular node in normal and failing rabbit hearts
… in LVD compared to control. Furthermore, using optical mapping of electrical activation using voltage sensitive dye I observed that the prolongation of the AH interval is predominantly a consequence of conduction delay between the inputs of the AV node and the compact nodal region. …
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Atrial Arrhythmogenic Substrates: The Role of Structure and Molecular Remodeling
… such as high throughput quantitative PCR, optical coherence tomography, and optical mapping. Only truly integrative approaches to arrhythmia research, combining a variety of experimental models and techniques, can continue to unravel the complexities of underlying molecular, structural, and …
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New Paradigm of Defibrillation: Towards Painless Therapy
… shock. Through the use of novel fluorescent optical mapping techniques and several animal models of ventricular and atrial arrhythmias, we develop and validate several novel low-voltage defibrillation therapies for atrial and ventricular arrhythmias. Several important previous studies on …
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Arrhythmogenic mechanisms of acute cardiac infection
… was increased in infected hearts. Ex vivo optical mapping illustrated decreased conduction velocity in the infected heart and patch clamping of isolated cardiomyocytes revealed prolonged action potential duration, along with decreased potassium current density during infection. Pairing …
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Calcium Remodeling through Different Signaling Pathways in Heart Failure: Arrhythmogenesis Studies of Pyk2, Dystrophin, and β-adrenergic Receptor Signaling
… in heart failure. To achieve this goal, a dual optical mapping system was designed to investigate electrical activity and Ca transient simultaneously. High spatio-temporal resolution mapping allows for quantifying conduction, repolarization and Ca cycling, especially on the interactions between …
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Effects of Perfusate Solution Composition on the Relationship between Cardiac Conduction Velocity and Gap Junction Coupling
… changes from the use of 3D printed bath for optical mapping procedures. After verification that the bath did not modify electrophysiological or contrile parameters, I studied the effects of physiologic changes to EpC determinants ([Na+]o and [K+]o) on CV during various states of GJ inhibition …
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High Resolution Multi-parametric Diagnostics and Therapy of Atrial Fibrillation: Chasing Arrhythmia Vulnerabilities in the Spatial Domain
… organization of AF, we used transillumination optical mapping to evaluate the presence of three-dimensional electrical substrate variations within the transmural wall during acutely induced episodes of AF. The results of this study suggest that transmural propagation may play a role in AF …
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Investigation of new semiconductor materials for wide band-gap devices
This thesis investigates the compositional and optical properties of wide bandgap III-nitride and gallium oxide semiconductor materials using scanning electron microscopy techniques. The primarily used techniques used here were wavelength dispersive X-ray spectroscopy (WDX) and cathodoluminescence …
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Arrhythmia mechanisms in acute ischaemia and chronic infarction in rabbit heart
… a combination of a novel snare technique and optical mapping. The purpose of this approach was to discover the mechanistic link between acute coronary infarction and the occurrence of arrhythmias. The electrophysiology of the epicardial surface of isolated hearts was examined using the voltage …
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Novel Systems Physiology Instrumentation: Addressing Limitations in Heart Failure Reseearch
… imaging technology for electromechanical mapping, and treatment of arrhythmias associated with heart failure. First, I present a miniature, implantable pacemaker for mice as a tool for investigating pacing-induced heart failure and cardiac memory. In previous studies, reliable, chronic …
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Role genu Nkx2.5 v morfogenezi a elektrofyziologii srdce u myši
Role genu Nkx2.5 v morfogenezi a elektrofyziologii srdce u myši Praha 2016 Bc. Peter Hámor ABSTRAKT Cieľom tejto práce je skúmanie vplyvu dávkovania génu Nkx2.5 na elektrofyziológiu srdca myší v prenatálnom období vývoja. Hlavnou úlohou je hľadanie rozdielov vo vedení elektrického vzruchu v srdci …