Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"optical clearing"”.
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Development of Mechanical Optical Clearing Devices for Improved Light Delivery in Optical Diagnostics
… disease using light. While there are a myriad of optical systems that have been developed for biological tissue imaging, optical diagnostics, and optical therapeutics, all of these methods suffer severely limited penetration depths due to attenuation of light by tissue constituent chromophores, …
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Localized Mechanical Compression as a Technique for the Modification of Biological Tissue Optical Properties
Tissue optical clearing aims to increase the penetration depth of near-collimated light in biological tissue to enhance optical diagnostic, therapeutic, and cosmetic procedures. Previous studies have shown the effects of chemical optical clearing on tissue optical properties. Drawbacks associated …
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High throughput 3-D tissue cytometry
… can be improved by reducing tissue scattering. Optical clearing agents can significantly lower tissue scattering by index matching of different tissue constituents. While the application of tissue clearing agent has been extensively studied in fresh tissues, its application has not been …
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Rapid evaluation of pathology using nonlinear microscopy with applications in breast cancer, prostate cancer, and renal disease
… readings of NLM images to assess accuracy. An optical clearing and staining technique for rapid three-dimensional analysis of renal biopsies was developed. Overall, this thesis aims to provide a new approach for intraoperative/intraprocedural consultation with NLM, potentially enabling more …
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Recapitulating mammary gland development and breast cancer cell migration in vitro using 3D engineered scaffolds
… by immunofluorescence microscopy coupled with an optical clearing technique. These data demonstrated the utility of the model in determining both the rate and capacity of tumour cells to migrate through the engineered stroma while shedding light also on the mode of migration. Moreover, the …
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THE ROLE OF ROMA IN MOUSE MAMMARY EPITHELIAL CELLS
… during early pregnancy. Additionally, a novel optical-clearing and confocal imaging technique (CUBIC R1a) was used to clear the mammary gland and visualise the extensive disorganisation of MECs in the Roma-knockout mice during lactation. This finding may suggest a potential role for Roma in …
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Elucidation of mammary gland development: combination of novel techniques to study proliferation and stem cells
… first involves development and optimisation of optical tissue clearing techniques to allow the visualisation of the native mammary gland, in situ, and in three dimensions. To do so, a number of different optical tissue clearing methods have been assessed and combined with a variety of microscopy …