Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"optic neuritis"”.
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Clinical profile, causes, and outcomes of optic neuritis at Groote Schuur Hospital
… therapy in patients admitted and treated for optic neuritis at a tertiary hospital in Cape Town, South Africa. Methods: A retrospective case review was conducted of 117 patients admitted to Groote Schuur Hospital and treated for optic neuritis between January 2002 and December 2012. Inclusion …
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Involvement of N-type voltage dependent calcium channels in axon degeneration during experimental autoimmune optic neuritis
… Nervensystems (ZNS). In der Folge einer Optikusneuritis entwickeln etwa 30-50 % der Patienten eine bleibende Sehbehinderung verursacht durch eine Degeneration von Sehnerv-Axonen. In Vorarbeiten konnten wir zeigen, dass die experimentelle autoimmune Enzephalomyelitis (EAE), ausgelöst durch …
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A study of pupil response components in human vision
… disorders such as multiple sclerosis and optic neuritis also confirm the existence of distinct pupil response components and reveal selective loss to chromatic and luminance pathways. The results indicate a preferential damage to thinner axons which are thought to predominantly mediate the …
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A study of pupil response components in human vision
… disorders such as multiple sclerosis and optic neuritis also confirm the existence of distinct pupil response components and reveal selective loss to chromatic and luminance pathways. The results indicate a preferential damage to thinner axons which are thought to predominantly mediate the …
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Implications of Dysregulated Antibody Hypermutation Patterns in Multiple Sclerosis Patients
… patients at high risk for converting to MS: optic neuritis (ONCIS) and transverse myelitis (TMCIS). Through my work in analyzing antibody genomics, I demonstrated that the AGS is present at the site of MS disease, within the CNS tissue. This provides support for the study of CSF B cells since …
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A retrospective study of patients with biologics treatment at Groote Schuur and Red Cross Children's War Memorial Hospitals
… ophthalmology (n= 25; 6 scleritis, 18 uveitis, 1 optic neuritis), and paediatrics (n= 45, 26 juvenile idiopathic arthritis , 12 SLE, 7 other conditions). The bDMARDs used were TNF inhibitors (112), rituximab (55), tocilizumab (10), anakinra (3), abatacept (1), and tofacitinib (1). The vast …
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New objective and psychophysical techniques to study the processing of visual signals with emphasis on chromatic afterimages
… three subjects with Leber’s Hereditary Optic Neuropathy (LHON) and one subject with Optic Neuritis were investigated using this approach. The results from the LHON subjects suggest not all classes of ganglion cells are affected uniformly in LHON, and that the pupil light reflex responses …
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An audit of the epidemiological, clinical features and outcomes of patients with Neuromyelitis Optica Spectrum Disorder (NMOSD) attending a South African Tertiary referral Hospital
… classically characterised by recurrent bouts of optic neuritis and myelitis. The pathogenic anti-aquaporin-4 antibody is present in most cases and distinguishes it from other forms of inflammatory CNS demyelination. This biomarker has led to recognising a broader clinical spectrum of NMOSD. …
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Efficacy and safety of novel and repurposed drugs for the treatment of drug-resistant tuberculosis
… neuropathy (63.6% versus 14.6%; p=0.003), and optic neuritis (18.2% versus 9.8%; p=0.34) occurred more frequently in linezolid interrupters than in non-interrupters. The third study showed that the use of delamanid-bedaquiline combination regimen was safe and efficacious in drug resistant TB …
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Die Wirkung eines RGMa-Antikörpers im Optikusneuritis-Modell
… Bei Brown Norway Ratten mit autoimmuner Optikusneuritis, induziert durch Immunisierung mit Myelin-Oligodendrozyten-Glykoprotein, wurde mittels intraperitonealer Applikation von 1 oder 4 mg/kg Körpergewicht dosierten RGMa-Antikörper weder ein Effekt auf die entzündliche Infiltration in den …