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Showing 1 to 6 of 6 for “"optic nerve crush"”.
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Analysis of Zebrafish Optic Tectum Visual Processing Before and After Optic Nerve Crush
… the retina, which then sends information to the optic tectum, the first visual brain center in lower vertebrates, for further processing. There were two main goals of this study. The first goal was to obtain tectal evoked responses (TER) from adult zebrafish and to compare them to previous …
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Systemic AAV-Mediated Gene Therapy Using Epo-R76E to Protect Retinal Ganglion Cells from Optic Nerve Injury and Disease
… and a spontaneous model of glaucoma.</p> <p>Optic nerve crush is a model of retinal ganglion cell (RGC) death. Crushing the optic nerve causes the axons to undergo Wallerian degeneration and apoptotic loss of retinal ganglion cells over time. This pattern of cell death is very similar to that …
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Spectral Sensitivity of the Goldfish ERG and Optic Tectum Before and After Optic Nerve Damage
… determine the return of function of the goldfish optic nerve at four time intervals after damage (crush). An increment threshold procedure was used to obtain electroretinogram (ERG) and tectal responses to light onset and termination to various wavelengths of light. Spectral sensitivity functions …
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MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
… vitro model of the glial scar and in vivo, using optic nerve crush (ONC) in adult mice. ARSB is clinically approved for replacement therapy in patients with mucopolysaccharidosis VI and therefore represents an attractive candidate for translation to the human CNS. My findings illustrate the …
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Promoting Central Nervous System Regeneration by Targeting Intracellular Pathways
… enhanced axon regeneration in a mouse model of optic nerve crush 2 weeks after injury. Live-cell imaging experiments revealed that this increased regenerative ability is accompanied with increased transport of Rab11 endosomes as well as growth receptors into the axon. Importantly, by further …
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The Effect of Manipulation of the Phosphoinositide 3-kinase Pathway on Axon Regeneration in vivo
Millions worldwide are visually impaired by optic nerve diseases, and glaucoma, the leading cause of irreversible blindness, is due to affect approximately 80 million people by 2020. The optic nerve is comprised of retinal ganglion cell (RGC) axons, and like all mammalian central nervous system …