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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 104 for “"optic nerve"”.
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Optic Nerve Head Image Analysis for Glaucoma Progression Detection
… care. In the glaucoma clinic, retinal and optic nerve head (ONH) imaging can be used to help the clinician to manage patient treatment appropriately. By providing high resolution images of the optic nerve head structures and identifying changes therein related to disease onset and …
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Optic nerve subarachnoid space cerebral spinal fluid computational fluid dynamics
… functions. The behavior of CSF within the optic nerve subarachnoid space (ONSAS) has special interest because it is relatively unknown. Additionally, the effects of improper flow characteristics of CSF within the ONSAS could be a contributing factor to optical neuropathies such as glaucoma. …
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Biomarkers of Optic Nerve Head Glial Cell Activation Following Biomechanical Insult
… death of retinal ganglion cells, a unique optic nerve neuropathy resulting in loss of vision. Increased intra-ocular pressure is known to be a leading risk-factor for glaucoma, and lowering IOP is currently the only evidence based method for the clinical management of the disease. However …
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Cell-specific roles for CASK in the pathology of Optic Nerve Hypoplasia
Optic Nerve Hypoplasia (ONH) is the leading cause of childhood blindness in developed nations and its prevalence has been rising. Yet, we know little about the genetic, molecular, or cellular mechanisms underlying ONH. A previous study described ONH in a cohort of patients with mutations in CASK, …
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Analysis of Zebrafish Optic Tectum Visual Processing Before and After Optic Nerve Crush
… the retina, which then sends information to the optic tectum, the first visual brain center in lower vertebrates, for further processing. There were two main goals of this study. The first goal was to obtain tectal evoked responses (TER) from adult zebrafish and to compare them to previous …
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Spectral Sensitivity of the Goldfish ERG and Optic Tectum Before and After Optic Nerve Damage
… determine the return of function of the goldfish optic nerve at four time intervals after damage (crush). An increment threshold procedure was used to obtain electroretinogram (ERG) and tectal responses to light onset and termination to various wavelengths of light. Spectral sensitivity functions …
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Lamina Cribrosa and Optic Nerve Head Geometry as a Function of Myopia in Older Normal Eyes
… of glaucoma. However, their impact on optic nerve head (ONH) structure in normal eyes has not been fully described. We examined whether differences exist in ONH and lamina cribrosa structure with myopia in older normal eyes. Methods: Spectral domain optical coherence tomography (SDOCT) …
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Systemic AAV-Mediated Gene Therapy Using Epo-R76E to Protect Retinal Ganglion Cells from Optic Nerve Injury and Disease
… and a spontaneous model of glaucoma.</p> <p>Optic nerve crush is a model of retinal ganglion cell (RGC) death. Crushing the optic nerve causes the axons to undergo Wallerian degeneration and apoptotic loss of retinal ganglion cells over time. This pattern of cell death is very similar to that …
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Glial Changes and Role of Connexin43 in a Laser-induced Rodent Model of Retrobulbar Optic europathy
Purpose: To establish a novel model of rodent optic nerve damage in order to investigate glial changes occurring in retrobulbar portion of the optic nerve after the injury and to facilitate development of neuroprotective agents. Methods: Rats (200-250g) were first anaesthetised via intraperitoneal …
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Identification and Characterization of the Expression Profile of Oligodendrocyte-Derived and Associated Proteins via Unilateral X-Irradation of the Rat Optic Nerve
… can be selectively eliminated from one optic nerve of a rat by treating the animal with a unilateral exposure of X-irradiation at the time of birth. Consequently, this approach allowed us to experimentally create, within the same animal, one optic nerve devoid of oligodendrocytes and …
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The identification and measurement of autistic features in children with optic nerve hypoplasia, "isolated" hypopituitarism and varying combinations of septo-optic Dysplasia
… have identified that some children with Septo Optic Dysplasia and Optic Nerve Hypoplasia demonstrate autistic phenomenology (Parr et al., 2008; Ek et al., 2005; Pring & Ockelford 2005; Bahar et al., 2003). It was found in fifty-six children, aged between four to sixteen, with isolated …
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Ultrasound as a non-invasive diagnostic tool in paediatric neurosurgery : relationship between the optic nerve sheath diameter (ONSD) and intracranial pressure (ICP)
… transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) and invasively measured ICP in children, as well as the influence of relevant physiological and demographic variables on this relationship. Methodology: ONSD measurement was performed using a high frequency, small …
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Sonographie des Sehnerven zum Ausschluß erhöhten Hirndrucks bei Kindern
… a sonographically measurable enlargement of the optic nerve. Aim of this study was to determine the value of this method in routine diagnostic of raised intracranial pressure. Main emphasis in this case was laid on the examination of possible influencing variables as well as the setting of a …
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Transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) as a screening tool for raised intracranial pressure in an acute care setting in children
… raised ICP will result in an enlargement of the optic nerve sheath diameter (ONSD), this study aimed to demonstrate the efficacy of transorbital measurement of the ONSD as a routine screening tool in pediatric TBI. Methodology: This was a prospective observational analysis of a pediatric cohort …
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Bestimmung von arteriovenöser Passagezeit, Farbstoffbolusgeschwindigkeit und Steigung des Farbstoffeinstroms sowie Berechnung des okulären Blutflusses in den retinalen Blutgefäßen bei Normaldruckglaukompatienten mittels Scanning-Laser-Fluoreszein-Angiographie
Circulatory deficits around the optic nerve head are a primary factor in the pathogenesis of the Normal-Tension-Glaucoma. In this study AVP and FBG were measured and as in previous studies a slower velocity in NDG-Patients. However, the ocular blood flow is of primary importance for the nutrition …
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ΕΠΙΔΡΑΣΗ ΤΗΣ ΔΙΑΤΟΜΗΣ ΤΟΥ ΟΠΤΙΚΟΥ ΝΕΥΡΟΥ ΕΠΙ ΤΗΣ ΕΝΔΟΦΘΑΛΜΙΟΥ ΠΙΕΣΕΩΣ ΚΑΙ ΔΡΑΣΕΩΣ ΩΣΜΩΤΙΚΩΝ ΚΑΙ ΜΗ ΔΙΟΥΡΗΤΙΚΩΝ ΣΕ ΑΥΤΗΝ
UNILATERAL OPTICAL NERVE TRANSECTION WAS CARRIED OUT RETROBULBARY AND A SHAM PROCEDURE WAS PERFORMED ON THE FELLOW EYE IN RABBITS. BASELINE I.O.P. VALUES, AS WELL AS I.O.P. RESPONSE TO SYSTEMICALLY ADMINISTERED OSMOTIC AGENTS (UREA, MANNITOL AND ASCORBIC ACID), ACETAZOLAMIDE, FUROSEMIDE, NACL O,9% …
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Mechanism of CASK-linked ophthalmological disorders
… mutations are also frequently associated with optic nerve hypoplasia (ONH) which is the most common cause of childhood blindness in developed countries. Some patients with mutations in CASK have been also diagnosed with optic nerve atrophy (ONA) and glaucoma. We have used floxed CASK …
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Finite element modeling of the human eye
… and magnitude of peak stresses in the retina and optic nerve head during initial loading. After 0.6125 ms, stresses as high as 5.4 x 10⁷ Pa were reached. The peak stresses occurred in the portions of the retina and the optic nerve head close to the boundary between these two substructures.
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Ultrasound Examination of the Optic Nerve in Patients with Clinical and Imaging Evidence of Increased Intracranial Pressure // Ултразвуково изследване на зрителния нерв при пациенти с клинични и образни данни за повишено вътречерепно налягане
… ликвор и менинги наречени обвивка на очния нерв (optic nerve sheath). Hayreh et al. доказват че има комуникация между интракраниалния ликвор и субарахноидалното пространство на очния нерв. Оказва се, че диаметърът на нерва се увеличава секунди след рязко повишаване на ВЧН. Helmke и Hansen …
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