Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"opportunistic infection"”.
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Target Based Design And Synthesis of Heterocycles in the Potential Treatment of Cancer and Opportunistic Infection
… details of the coupling reaction.<br /> Opportunistic infection by Pneumocystis jirovecii in immunocompromised patients such as organ transplant, cancer and AIDS patients is associated with high mortality. The current treatment involving the use of a combination of trimethoprim and …
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Design and Synthesis of Pyrimidine Based Fused Heterocyclics in the Potential Treatment of Cancer and Opportunistic Infection
… an important strategy for effective treatment of infection by the pathogen. Structure-based design, using pjDHFR homology model and through the identification of amino acid differences between pjDHFR and hDHFR active sites, has been presented in the text. Novel synthetic strategies were developed …
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Target Based Design and Synthesis of Fused Pyrimidines in the Potential Treatment of Cancer and Opportunistic Infection
… inhibitors for pneumocystis pneumonia (PCP) infection; (b) inhibitors of microtubule polymerization and multiple receptor tyrosine kinase (RTK) for potential treatment of cancer; and (c) substrates for tumor-targeted therapy for cancer.</p> <p>PCP is a host species-specific infection. Most of …
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Exploring the experiences and perceptions of adolescents and young adults of adherence to antiretroviral therapy treatment at a referral opportunistic infection clinic in Harare, Zimbabwe
… therapy (ART) adherence among AYAs at a referral Opportunistic Infection Clinic in Harare, Zimbabwe. Methodology: The study employed qualitative methods, where data was collected through semi-structured in-depth interviews with 12 AYAs and 5 key informants at a referral Opportunistic Infection …
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The molecular diagnosis of Pneumocystis pneumonia in children using nasopharyngeal aspirate samples
Pneumocystis pneumonia (PCP) is an important opportunistic infection caused by thefungus Pneumocystis jirovecii. The incidence of PCP in sub-Saharan Africa is on theincrease. This is due to the progression of the HIV-pandemic and limited access to healthcare facilities, specific highly active …
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Opportunistic infections in Edinburgh AIDS patients: 1984-1994
… features and outcome of major AIDSrelated opportunistic infections in a cohort of HIV-seropositive patients attending Edinburgh's City Hospital between 1984 and 1994. To determine which clinical features are ofprognostic significance in opportunistic infections and the effect of …
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Retrospective analysis of outcomes in the programme of fast-tracking of antiretroviral therapy for patients admitted to a palliative care centre after diagnosis of opportunistic infections
… of 200 cells/uL, immediate ART initiation after opportunistic infection (OI) treatment in the inpatient wards at several international sites has been shown to reduce the adverse outcomes of AIDS progression and death. Current South African policies of discharging patients after hospital admission …
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The pharmacokinetics of lopinavir in HIV-infected adults receiving rifampicin with adjusted doses of lopinavir
… virus (HIV). Tuberculosis is the most common opportunistic infection in patients infected with HIV. Although antiretroviral therapy (ART) has decreased the burden of tuberculosis in HIV-infected patients, the incidence of tuberculosis remains higher than in the general population. …
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Using Evolutionary Genomics to Elucidate Parasite Biology and Host-Pathogen Interactions
… neurological birth defects, and a prominent opportunistic infection in immunosuppressed individuals). In particular, we have explored the significance of lateral gene transfer and gene duplication as sources of evolutionary novelty . Genomic-scale phylogenetic tree comparison identifies …
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The PLK1 and NLRP3 interactome in NLRP3 inflammasome activation
… inflammasome pathways, can increase the rate of opportunistic infection. Identification of novel players specifically regulating the NLRP3 inflammasome could therefore lead to the development of new therapeutic strategies. Our unpublished work has identified the Polo-like kinase (PLK1) as a …
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Bioactivation of diacetyldapsone in cultured lung cells
… agent against Pneumocystis carinii pneumonia, an opportunistic infection in AIDS patients. Oral administration of dapsone is associated with several adverse effects, including methemoglobinemia, hemolytic anemia and photosensitivity reactions. To reduce the adverse effects associated with oral …
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Impact of Thymectomy on the Peripheral T Cell Pool in the Context of SIV Infection
… context of human immunodeficiency virus (HIV)-1 infection, in which the progressive loss of CD4+ T cells leads to immunodeficiency and opportunistic infection. CD4+ T cell loss is thought to result from direct and indirect killing of CD4 cells in the periphery as well as from pathogenic effects …
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Towards Phage Therapy: Characterization of Clostridioides difficile Bacteriophages from a South African Strain Collection
Clostridioides difficile infection is a worldwide public health concern that affects persons with gastrointestinal dysbiosis, notably hospitalised patients on antibiotic therapy and those with other types of gastrointestinal conditions. This opportunistic infection is caused by a Grampositive, …
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Analysis of clnical features of cryptococcosis and antifungal susceptibility of clinical isolates in Korea
… Cryptoccosis which is emerged as important opportunistic infection in immunosuppressed pateint is caused by Cryptococcus neoformans/C. gattii. Cryptococcus neoformans/C. gattii has four subtypes (VNI, VNII, VNIII, VNIV for C. neoformans, VGI, VGII, VGIII, VGIV for C.gattii). Each subtypes …
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Oral lesions in hiv/aids patients before and after haart treatment
… immune responses and decrease susceptibility to opportunistic pathogens. Aim: The aim of the present study was to determine the prevalence of oral lesions in patients before and after undergoing HAART. Methods: The study design was longitudinal and descriptive, investigating the prevalence of …
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Clinical Implications of HIV-1, HSV-2 Co-infection and Opportunities for Intervention
… in HIV. I evaluated the impact of HSV-2 co-infection on (highly active antiretroviral therapy)-untreated HIV infection in a systematic review of observational studies (study 1) and a retrospective cohort (study 2). I further evaluated whether HSV reactivation rates in co-infected persons …
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The Use of Natural Product Substrates for the Synthesis of Libraries of Biologically Active, New Chemical Entities
… possible by eliminating the possibility of opportunistic infection. However, during the past 30 years many of the infections that were once easily cured by the proper antibiotic are no longer so due to a precipitous rise in multi-drug resistant organisms. This rise in multi-drug resistant …
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The Use of Natural Product Substrates for the Synthesis of Libraries of Biologically Active, New Chemical Entities
… possible by eliminating the possibility of opportunistic infection. However, during the past 30 years many of the infections that were once easily cured by the proper antibiotic are no longer so due to a precipitous rise in multi-drug resistant organisms. This rise in multi-drug resistant …
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Human Cytomegalovirus and the Neutrophil
… cytomegalovirus (HCMV) is a highly prevalent opportunistic infection and a major pathogen in immune-compromised patients. The virus exhibits a wide cell tropism and is able to lytically infect virtually any cell type, with detectable gene expression and release of new virions, but not the …
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Finding NEMO by the molluscum contagiosum virus MC159 protein and its effect on viral pathogenesis in vivo
… poxvirus that solely infects humans. MCV infections causes benign neoplastic lesions that can persists for few months in children and adults. It is an opportunistic infection in immunocompromised patients. Currently there is no FDA approved drug available for MCV infections. The knowledge …
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