Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"opioid use disorder"”.
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Molecular Mechanisms of Opioid Use Disorder in Human Brain Models
<p>Opioid use disorder (OUD) is a national and global public health crisis with no end in sight. While studies from animal models hint at widespread epigenetic and transcriptomic alterations of opioid drugs, the molecular consequences of long-term exposure to opioid drugs in human brain is still …
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Improving prediction of opioid use disorder with machine learning algorithms
Opioid Use Disorder (OUD) refers to a concerning pattern of opioid use that results in considerable impairment or distress. It is a chronic and treatable condition that can impact individuals irrespective of their race, gender, income, or social standing. Therefore, accurately predicting …
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Identification and treatment of opioid use disorder in the emergency department
Background: Opioid Use Disorder (OUD) is a common comorbidity in emergency department (ED) settings. This study aimed to introduce a standard of care that incorporates medication-assisted treatment and facilitates referrals for continuous therapy among individuals with OUD seeking assistance in the …
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The Impact of Pain on Key Outcomes in Opioid Use Disorder Recovery
Opioid misuse and addiction constitute a significant public health challenge in the 21st century, with opioids involved in the majority of drug overdose deaths since 1999. A vigorously researched area that contributes substantially to the opioid misuse and addiction challenge is pain. The impact of …
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The Impact of Neighbourhood-Level Marginalization on risk of Opioid Overdose and Opioid Use Disorder
Background: Canada is in the midst of an opioid crisis, characterized by a dramatic increase in opioid-related poisonings, deaths, and dependency over the course of several years. Neighbourhood-level marginalization, defined as the degree to which individuals living within a neighbourhood are …
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A Mixed Methods Exploration Of Stigma, Discrimination, And Sleep Among Those On Medication For Opioid Use Disorder
… occurs in as many as 75% of people with Opioid Use Disorder (OUD). The prevalence of insomnia is attributable to concurrent factors such as mental health disorders, chronic pain, and medication use; however the contribution of social factors is not well understood. Persistent social …
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Come as You Are: The Acceptability of Harm Reduction Approaches for Opioid Use Disorder among Professional Counselors
Over the last two decades, the Opioid Epidemic has caused immense harm to communities nationwide. Over 400,000 fatal opioid overdoses occurred in the United States between 1999 and 2017 (CDC, 2019). Professional counselors are among the front-line treatment providers addressing substance use, …
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The Impact of Military Sexual Trauma on Opioid Use Disorder and Related Outcomes in Men and Women Veterans
… aims related to military sexual trauma (MST) and opioid use disorder (OUD) among U.S. Veterans enrolled in Veterans Health Administration (VA) care. Specifically, aims were to (1) assess the relationship between MST and OUD, (2) assess the relationship between MST and treatment for OUD among …
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People with active opioid use disorder as first responders to opioid overdoses: Improving implementation intentions to administer naloxone
The ongoing opioid crisis presents a significant public health challenge particularly for people who use opioids (PWUO). Naloxone is an opioid antagonist crucial to reducing opioid overdose mortality. Inconsistencies exist among PWUO in obtaining, carrying, discussing, and administering naloxone. …
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Design, Synthesis, and Evaluation of Covalent CADA Analogues as Potent TLR4 Downmodulator for the Treatment of Opioid Use Disorder
… innate immune response and the pathogenesis of opioid use disorder (OUD). Opioids interact not only with neuronal sites but also with glial cells thereby activating these cells, thus leading to the release of neuroexcitatory substances and neuroinflammatory cytokines, contributing to …
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Sex differences in synaptic plasticity within the reward system: the role of PKMζ and implications for opioid use disorder
… fact that more men are diagnosed with substance use disorder, women escalate their drug consumption faster, exhibit higher craving during withdrawal, and have poorer treatment outcomes. Furthermore, as our cultural expectations of men and women have changed, there has been an increase in drug use …
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The Effect of a Mindfulness Intervention on the Depression Symptoms of Mothers in Treatment for an Opioid Use Disorder
<p>BACKGROUND: Mothers in treatment for an opioid use disorder experience a high prevalence of depression which may influence their relationship with their child. In the general population, mindfulness-based parenting intervention has been seen in the literature to have a clear positive effect on …
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Racial and geographical disparities in medication-assisted treatment completion for individuals with opioid use disorder in the Appalachian region
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Induction of transdermal buprenorphine (Butrans®) to extended-release buprenorphine subcutaneous injection (Sublocade®) for opioid use disorder: a case series & a qualitative study on the experiences, barriers, and understanding of opioid agonist treatment among youth with opioid use disorder in Vancouver, British Columbia
The opioid crisis is a profound public health crisis, with devastating impacts on individuals, families, and communities in North America. Vancouver is one of the most affected regions in Canada. To combat the rising opioid overdose epidemic, opioid agonist treatment and harm reduction services …
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The California Bridge Model For Emergency Department-Initiated Medication-Assisted Treatment For Opioid Use Disorder: Adaptations For Perinatal Hospital Services
… Poor access to gender-specific, pregnancy-focused medication-assisted treatment for perinatal opioid use disorder greatly contributes to adverse outcomes for pregnant patients, infants, and society, at large. It is well established that Emergency Department-initiated pharmacotherapy for opioid …
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Agreement between self-report and urine drug test results in a sample patients treated with buprenorphine for opioid use disorder
… to monitor primary care patients treated for opioid use disorder with buprenorphine. Whether UDT data contributes clinically useful information beyond patient self-report of drug use has received minimal attention. It is unclear whether differences between patient self-report and UDT results …
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Urban And Rural Comparisons Of Attitudes Toward Medically Assisted Treatment For Pregnant And Postpartum Women With Oud In Appalachia
The opioid crisis has plagued the United States but disproportionately affects the often-overlooked Appalachian region. This area faces unique barriers preventing better access to quality Opioid Use Disorder (OUD) treatment facilities despite opioid-related deaths continuing to rise. An especially …
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COMORBIDITY CONUNDRUM: ASSESSING TREATMENT PARTICIPATION AND RECIDIVISM OUTCOMES AMONG INCARCERATED INDIVIDUALS WITH CO-OCCURRING OPIOID USE AND MENTAL HEALTH DISORDERS
Opioid use disorder (OUD) is a serious and prevalent issue, particularly among justice-involved individuals. Formerly incarcerated individuals with OUD are at an increased risk for overdose death and recidivism and often have co-occurring mental health disorders (COD). Further, there are serious …
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A Geographic Framework for the Optimal Placement of Interventions for Opioid Treatment Deployment in Underserved Areas (OPIOID-UA)
… care system delivers care,; the crisis is the opioid overdose epidemic. The opioid overdose crisis in the United States (US) is well documented as overdose mortality has continued to climb year after year, is a leading cause of accidental death, and has contributed to a reduced life expectancy. …
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Ethical Considerations in Goals of Care for Patients with Polysubstance Use and Medical Complications in the Era of Xylazine
The opioid epidemic in Philadelphia has evolved into a complex polysubstance crisis with the emergence of xylazine alongside fentanyl, reshaping substance use dynamics. Xylazine's rising prevalence introduces unique health risks due to its sedative properties, compounded when combined with …
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