Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"opioid misuse"”.
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Young Women and the Initiation Trajectory of Prescription Opioid Misuse
<p>The most recent opioid epidemic in United States history emerged in the late 1980s and continues its destructive impact to this day. It has evolved into a devastating public health crisis with a broad range of medical, social, and economic consequences. This dissertation focuses on the “first …
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Health and social disparities influence opioid misuse among adult females living in rural areas
… and healthcare professionals know now as the "Opioid Epidemic." The opioid epidemic began around the early 1900s when doctors power to prescribe painkillers became more frequent and in larger quantities, to patients who suffered from more moderate pain (Quinones, 2015). This lead researchers …
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Prevention & Reduction of Opioid Misuse with Systems Exploration: Modelling complex, uncertain problems for policy development
The opioid crisis is one of the worst public health challenges in the United States, with overdoses killing over 50,000 people a year. The crisis is a complex and dynamic problem, with long delays and multiple feedbacks, in which any policy actions risk causing adverse unintended consequences. …
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Pain Intensity And Anxiety Sensitivity In Relation To Opioid Misuse And Dependence Among Individuals With Chronic Pain
… an estimated 68% of the world’s prescribed opioids each year, and over 2 million adults in the US suffer from an opioid use disorder. Although chronic pain populations are among the highest risk segments of the general population for opioid misuse and dependence, there is little …
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The Impact of Pain on Key Outcomes in Opioid Use Disorder Recovery
Opioid misuse and addiction constitute a significant public health challenge in the 21st century, with opioids involved in the majority of drug overdose deaths since 1999. A vigorously researched area that contributes substantially to the opioid misuse and addiction challenge is pain. The impact of …
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A Two-Pronged Approach to Stemming the Opioid Epidemic: Preclinical Strategies for Substance Use Disorder Medications Development and Liquid Biopsy Detection of Inflammatory Pain
… in the grips of a public health crisis driven by misuse of psychoactive drugs (e.g., prescription opioids, heroin). In consequence, this has generated a multitude of health issues, including overdoses, deaths and disability, as well as the increased incidence of opioid use disorder (OUD), a …
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Opioid overdose trends in children, adolescents and young adults
Introduction: The opioid epidemic has become a major public health problem in the United States, reaching record high mortality rates during the pandemic. While trends have been documented in adults, there is a need to examine these patterns among younger populations. Aim: This study analyzes …
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Reducing Opioid Use Following Posterior Spinal Fusion Procedures: A Pilot Project
<p>Importance: Opioid misuse and mortality remain a prevalent problem in the United States and there is a high rate of chronic opioid-use after spinal fusions. Current guidelines recommend the optimization of non-opioid analgesics as a primary pain control strategy with opioids acting as a …
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Safe injections sites as a solution to the opioid crisis : a policy analysis
Over the past 20 years, the fatality rate from opioid and drug overdoses has dramatically increased in the United States. Clearly, a solution is needed to address this vast and serious problem. While Michigan Governor Gretchen Whitmer recently enacted legislation investing over $800 million towards …
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Opioid Use after Transforaminal Lumbar Interbody Fusion: A Comparison between Open and Minimally Invasive Surgery
Background: Opioids are medications frequently used in patients with moderate and severe chronic pain. Their pharmacologic profile allows their use in acute severe postoperative pain. However, due to their highly addictive profile, opioid misuse is considered a public health issue. Vertebral spine …
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Additional Validation of the Pain Medication Questionnaire in a Sample of Patients with Chronic Pain
… used for assessing potential pain medication misuse risk. This study follows previous studies of Adams and colleagues (2004) and Holmes and colleagues (2006). The Pain Medication Questionnaire (PMQ), initially a 26-item instrument, was studied as a 23-item questionnaire designed to measure …
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Evaluating and Changing Postoperative Opioid Prescribing After Routine Pediatric Surgery
With continued concern regarding a national opioid epidemic, there is greater focus on physician narcotic prescribing practices as a potential contributing factor to increasing opioid misuse. In an effort to evaluate this potential among pediatric surgeons we designed a two phased study including …
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The Serotonin (5-HT) 5-HT2A Receptor is a Priority Target to Reduce Impulsive Action in Substance Use Disorders: Preclinical Evidence
… impulsive action evoked by the prescription opioid oxycodone, providing early evidence that pimavanserin may suppress impulsive opioid misuse. We explored the mPFC as a potential site of action for the 5-HT2AR to modulate impulsive action using viral-mediated knockdown of 5-HT2AR protein …
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The TAP Block: A Multimodal Regional Analgesic Approach to Abdominal Surgery
… The TAP block plays a role in minimizing opioid requirements after abdominal surgery, with ample evidence showing the positive analgesic effects, safety, and effectiveness of outcomes. However, many anesthesia providers do not use this block as part of a multimodal regional anesthesia …
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DISRUPTED GABA SIGNALING IN THE VENTRAL TEGMENTAL AREA DRIVES ADDICTION-LIKE BEHAVIORS
… and disability. Most prominent among these, opioid misuse and dependence have become a devastating crisis. Despite this, a complete understanding of the neural circuit adaptations driving substance use disorders remains unknown.Animal models have revealed a key role of the mesolimbic dopamine …
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Computer-Administered Patient Reported Outcomes (PRO) and Psychiatric Screening in Outpatient Pain Patients: Effect of a Point-of-Care Biopsychosocial Patient Health Report on Treatment Outcomes
… screen; Pain Medication Questionnaire [PMQ; opioid misuse risk]), global HRQoL (PROMIS Mental and Physical Health domains), treatment alliance (Working Alliance Inventory [WAI]; ratings from both patients and providers]), and illness perception and optimism (Brief Illness Perception …
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Predictors of the Risk for Aberrant Drug-Related Behavior in Chronic Pain Patients: A Mixed Methods Design
<p>The use of opioids for the treatment of chronic non-cancer pain (CNCP) remains controversial (Manchikanti, 2008; McQuay, 1999). Controversy surrounds the type of conditions that should be treated with opioids, whether the treatment can be generally safe and effective, and what the clinical goals …
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Induction of transdermal buprenorphine (Butrans®) to extended-release buprenorphine subcutaneous injection (Sublocade®) for opioid use disorder: a case series & a qualitative study on the experiences, barriers, and understanding of opioid agonist treatment among youth with opioid use disorder in Vancouver, British Columbia
The opioid crisis is a profound public health crisis, with devastating impacts on individuals, families, and communities in North America. Vancouver is one of the most affected regions in Canada. To combat the rising opioid overdose epidemic, opioid agonist treatment and harm reduction services …
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Rural Community Perspectives and Actions Taken to Build Consensus on the Opioid Crisis in Southern Virginia: A Community-Based Participatory Multiphase Mixed Methods Study
Background: Opioid use disorder (OUD), prescription opioid misuse, and increased heroin use are major public health crises in the US. Excessive non-medical use of prescription opioids and illicit drugs can alter the brain, disrupt mental health, and increase the risk of blood-borne illnesses and …
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