Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"opioid agonists"”.
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Ligand-based drug design : I. conformational studies of GBR 12909 analogs as cocaine antagonists; II. 3d-QSAR studies of salvinorin a analogs as kappa opioid agonists
… (for example, monoamine transporter proteins and opioid receptor proteins) are unknown as these proteins are notoriously difficult to crystallize. In Part I of this study, analogs of the flexible dopamine reuptake inhibitor, GBR 12909, may have potential usefulness in the treatment of cocaine …
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Opioid induction of Fos in the female rat brain : modulation by ovarian hormones
Previous research has shown that opioid drugs have profound effects on female reproduction. It has also been established that ovarian hormones exert control over opioid peptide synthesis and opioid receptor gene expression. The present thesis investigated functional pathways by which opioids affect …
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The Role of Gonadal Hormones on Opioid Receptor Protein Density in Arthritic Rats
The majority of research on the endogenous opioid system has focused on various pain assays and the efficacy of different opioid agonists. However, minimal attention has been focused on the effects of gonadal hormones and their impact on the opioid peptide system. The present study was designed to …
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Synthesis towards Salvinorin Scaffold to Develop a Potential Pain Therapeutic and Selective, Potent Kappa Opioid Ligands
… who have sought after traditional therapy, opioid analgesics. Particularly in patients with chronic pancreatitis, traditional therapy has failed to assist with pain management causing daily activity to be an even bigger challenge. Drugs like morphine or codeine, mu opioid agonists, have been …
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Investigating intrathecal adeno-associated virus vectors for the study of analgesic interactions at the spinal level
… Several G protein-coupled receptors, including opioid and adrenergic receptors, are known to be potent regulators of pain signaling at the spinal level. Co-activation of different subtypes of these receptors can lead to synergistic inhibition of pain signaling. Understanding how these receptors …
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Opioid inhibition of the growth of the transplantable androgen-responsive (AR) Shionogi mouse mammary carcinoma (SC115)
… carcinoma (SC115). In addition, the effects of opioid agonists and antagonists on the growth of SC115tumor cells in primary culture were examined. The possible role of opioids in mediating the differential tumor growth rates of mice exposed to experimental housing groups was also examined.SC115 …
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A TALE OF TWO STRESS MODULATORS: EFFECT OF DELTA OPIOID RECEPTOR AGONISM AND FKBP5 INHIBITION ON GENE EXPRESSION AND BEHAVIOR DURING COCAINE WITHDRAWAL
… responses during cocaine withdrawal. Delta opioid receptors (DOR) are involved in pain modulation and further play a role in the regulation of mood. Delta opioid agonists can reduce stress-induced and cocaine withdrawal-induced negative affect in rodents. Although the mechanism underlying …