Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 449 for “"opioid"”.
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Opioid Prescribing and Opioid-Related Health Outcomes Among Cancer Survivors
… curative treatment is approximately 40% and opioids are frequently prescribed to manage the pain. The purpose of this dissertation is to explore long-term opioid therapy and opioid-related harms in cancer survivors using Surveillance Epidemiology and End Results – Medicare linked datasets. …
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The Association of Prescription Opioid Exposure and Patient Factors with Prolonged Postoperative Opioid Use in Opioid Naive Patients
… <p>Research suggests prolonged postoperative opioid use occurs in 4-13% of opioid naïve patients and is related to factors other than surgical pain. However, it is unclear which patient factors and prescribing practices are associated with prolonged use after surgery among opioid naïve …
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The Impact of Neighbourhood-Level Marginalization on risk of Opioid Overdose and Opioid Use Disorder
Background: Canada is in the midst of an opioid crisis, characterized by a dramatic increase in opioid-related poisonings, deaths, and dependency over the course of several years. Neighbourhood-level marginalization, defined as the degree to which individuals living within a neighbourhood are …
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Creating An Integrated Opioid Policy For Multi-State Hospice Practices: Improving Opioid Compliance And Patient Safety
… towards end of life. For those patients at EOL, opioids are the mainstay treatment to relieve intractable and breakthrough pain. Due to opioid regulatory changes over the past few years, there has been more confusion than clarity among the hospice & palliative care practitioners prescribing …
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Comparative Long-term Outcomes of Detoxification and Opioid Maintenance Therapy for the Management of Opioid Dependence
… management of dependence to illicit opioids detoxification and opioid maintenance therapy (OMT) are the primary treatment options. Over the past decade the United Kingdom has seen a mostly political push towards a more abstinence-oriented treatment agenda and away from the prevailing …
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Molecular Regulation of Opioid Receptor Signaling
The varied behavioral effects of kappa opioid receptors (KOR) are mediated through different signaling cascades. KOR activation of G protein-dependent signaling results in analgesia, whereas the dysphoric effects are mediated by a different pathway involving G protein-coupled receptor kinase (GRK) …
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Optimizing Opioid Prescription for Outpatient Surgery
INTRODUCTION: Opioid overprescribing by surgeons has contributed to the current opioid epidemic. This has occurred both from the transition of patients to chronic opioid use after initial use for acute pain only and from diversion of unused opioids from prescriptions intended for acute surgical …
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A Geographic Framework for the Optimal Placement of Interventions for Opioid Treatment Deployment in Underserved Areas (OPIOID-UA)
… care system delivers care,; the crisis is the opioid overdose epidemic. The opioid overdose crisis in the United States (US) is well documented as overdose mortality has continued to climb year after year, is a leading cause of accidental death, and has contributed to a reduced life expectancy. …
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Predictors Of Dental Opioid Analgesic Prescribing, Opioid Use And Dental Emergency Department Visits In The Mississippi Medicaid Population
… this study were: (1) to determine prevalence of opioid analgesics prescribing for non-ED dental related visits in the Mississippi Medicaid population, (2) to assess predictors of receiving opioid analgesics following non-ED dental related events among Mississippi Medicaid beneficiaries, and (3) …
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People with active opioid use disorder as first responders to opioid overdoses: Improving implementation intentions to administer naloxone
The ongoing opioid crisis presents a significant public health challenge particularly for people who use opioids (PWUO). Naloxone is an opioid antagonist crucial to reducing opioid overdose mortality. Inconsistencies exist among PWUO in obtaining, carrying, discussing, and administering naloxone. …
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The Effects of Rhes on Opioid Analgesia
… in the striatum. Given the many effects of opioids that involve striatal circuitry, genetically engineered mice that are incapable of making Rhes (rhes-/-) and their control littermates (rhes+/+) were subjected to behavioral tests to determine if any differences existed in opioid analgesia, …
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Preventing Opioid Overdose: From Prediction to Operationalization
The opioid epidemic remains a significant public health challenge in the US. A potential catalyst for reducing the incidence of opioid-related harm is the development and operationalization of risk stratification models. Prior work has focused on the statistical performance of such models without …
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An Analysis of the Opioid Crisis in Nevada
… much of the research surrounding the National Opioid crisis focuses on overdose fatalities, this study seeks to examine the more understudied aspect of potential misuse, abuse and diversion in the form of high pill and morphine milligram equivalents (MMEs) of these opioid prescriptions in the …
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Predictors of prolonged opioid use following lumbar fusion
… 2.4 times between 1998 and 2008.2 Rates of opioid pain reliever (OPR) use at 24 months post-lumbar fusion have been reported in up to 30% to 67% of patients. Currently, the number of OPR-related deaths in the US exceeds deaths from motor vehicle accidents.3 The objective of this study is to …
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k-Opioid Receptor Dependent Cardioprotection in the Rat
<p>Activation of opioid receptors dramatically decreases the degree of ischemic damage in rat myocardium. This cardioprotective phenomenon <br />may be mediated by a protein kinase C (PKC)-dependent modification of myofibrillar proteins, leading to reduced ATP utilization by the <br …
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Opioid use and abuse in the United States
<p>Opioids have quadrupled the number of unintentional drug overdose deaths since 1999 and are now among the leading causes of death in the United States. Though some reform has recently occurred, the United States continues to operate largely under a punitive criminal justice model despite …
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