Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"open field test"”.
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Intermittent swim stress effects on anxiety behavior
… incorporated animal models of anxiety (i.e., open field test and juvenile social exploration), while serotonergic and noradrenergic neurons were assessed at the dorsal raphe nucleus and locus coeruleus, respectively, through immunohistochemistry techniques. Results indicated ISS-induced …
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ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST
… pathophysiology of depression. The forced swim test is a commonly used screening model for putative antidepressant medications. Drugs that have antidepressant effects in humans reliably decrease the time animals spend in an immobile posture in the forced swim test without increasing general …
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Effect of Cannabinoids and Stress on Motor Maps and Behaviour
… horizontal ladder rung walking task and the open field test. No differences were found between rats that received THC and rats that received DMSO on the rotorod, rung walking task and the open field test. The highest dose of THC used (2.5 mg/kg) resulted in a longer latency for removal of the …
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The Effects of Allopregnanolone on Feeding: A Behavioural Investigation
… behaviors, as measured by the taste reactivity test. In the lickometer test, allopregnanolone significantly increased the intake and licking of a sucrose solution, only when it was novel, indicating a reduction in neophobia (food related). In a lickometer/automated open field test, …
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Binge Alcohol and Recovery After Traumatic Brain Injury
… The factor that places one at perhaps the greatest risk of suffering a TBI is alcohol intoxication. 30-50% of TBI sufferers have a blood alcohol level above .08 mg/dl at the time of injury, the legal limit in most U.S. states. In fact, the presence of alcohol at the time of TBI more than …
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An Investigation of Anxiety- And Depression-Like Behavior after Head Trauma in Mice
… two purposes of this study: the first being to test the modified Marmarou TBI model, and second to investigate anxiety- and depression-like symptoms in C57Bl6/J mice following a TBI. The modified Marmarou model used different weights (95g, 30g, & sham) to see how severity affected the …
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THE CHARACTERIZATION OF BEHAVIORAL ABNORMALITIES IN BDNF LOXP TRANSGENIC MICE
… included home cage monitoring observations, open-field, tail suspension, and acoustic PPI to provide a detailed behavioral phenotype for BDNF<sup> lox+/+</sup> mice. Tail suspension protocols revealed progressive limb clasping deficits in BDNF<sup> lox+/+</sup> mice compared to control …
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Analysis of the behavioural effects of barley and sertraline in two in-vivo models of stress.Anti-depressant and anti-nociceptive effects of barley in mice and sertraline effects on anxiety in the offspring of prenatally-stressed rats
… of vehicle-treated PS mothers’. The forced swim test (FST) was used to examine depressive-like behaviour in mice. Barley successfully increased mobility in mice exposed to the FST. Barley was antidepressant at low doses (0.8g/kg and upwards) if used subchronic; and at high doses(6.4g/kg and …
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The differential effects of stressors on aversive, novel and appetitive stimuli in rats
… ethanol intake on the first post-restraint test only in animals deprived of ethanol on restraint days. Footshock decreased novelty-induced locomotion but only in the initial 5 min of the open-field test. Results of these studies indicate that stressors can alter response to aversive and …
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Plant growth under photovoltaic arrays of varying transparencies – a study of plant response to light and shadow in agrivoltaic systems
… Architecture (HLA) department has focused on open field specialty crops and native pollinator plant species while documenting the overarching light and temperature growing environment. A replicated 2-year crop trial was conducted at the open field test site, comparing crop yield and growing …
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Rats selectively-bred for low and high voluntary running: co-selected traits and the effects of voluntary running on the dentate gyrus transcriptome
… performance of LVR and HVR rats in behavioral tests classically designed to measure non-wheel running locomotor activity behavior (i.e. open field test), sensitivity to drugs of abuse (i.e. cocaine-induced locomotor activity), anxiety-like behavior (i.e. elevated plus maze), depressive-like …
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Biobehavioral responses to immune skew and free fatty acids
… in the naïve state (Moon et al., 2011). To test our hypothesis that skewing the immune system can alter biobehaviors exhibited in mice, we utilized two distinct models. In Chapter 2, the project of endogenous immune skew, interleukin-4 (IL-4) knock-out (KO) mice were behaviorally phenotyped. …
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Drug Treatments for Post-Traumatic Stress Disorder in a Mouse Model
… 2-weeks after FC, mice were placed in an open-field apparatus and assessed for behaviors indicative of anxiety, such as percent time spent in the center of the open field and escape behaviors. Results indicated that the combination ketamine/FLX treatment most effectively reduced …
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Soziale Belastung während der Trächtigkeit bei Long-Evans Laborratten (Rattus norvegicus) und ihre Effekte auf die Reproduktion sowie die Physiologie, das Verhalten und die Reproduktion ihrer Nachkommen
… charakterisiert werden (elevated plus maze und open-field Test). Weiterhin konnte im Blutserum der PS-Männchen eine geringere Konzentration des Stresshormons Corticosteron, sowohl unter standardisierten Haltungsbedingungen wie unter Belastung (ACTH challenge), festgestellt werden. Dieser Befund …
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A study of the WKY as a rat model of depression
… effects of ketamine have not been previously tested in male WKY or MS SD rats and it was therefore decided to study the behavioural effects of ketamine in these rat models of depression. The aim of the first study was to characterize the WKY rat model of depression and to select the …
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The Validation of Novel Ecological Survey Methods for Use in Describing Harvest Mouse Micromys minutus Autecology
… Here two novel methods were developed and tested, which included remote scent surveys using a detection dog and Radio Frequency Identification (RFID) trapping. After validation, RFID trapping was then used to quantify M. minutus movement in fragmented habitats. A preliminary study was …
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The differential effects of short-term physical exercise, environmental enrichment and their combination, and short- and long-term environmental enrichment on behavior and associated molecular changes in the brain of C57BL/6 mice
… depressive-like behavior in the forced swim test. Conversely, long-term EE reduced locomotion in the open-field test. Additionally, short-term EE showed anxiolytic effects in the elevated zero maze, while these effects were lost after long-term EE. EE, irrespective of duration, increased …
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Charakterisierung von Stereotypien bei der FVB/NJ-Maus hinsichtlich metabolischer und immunologischer Aspekte auf die Stoffwechselleistung
… begleitende Untersuchungen wie Verhaltenstests und die Erfassung der physischen Aktivität und metabolischer Parameter. Anschließend wurden u.a. die zerebralen Serotonin- und Dopamingehalte, fäkale Glucocorticoidlevels, hepatisches Glykogen und muskuläre Glykogen- und Triglyceridlevels …
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Optimisation of protein and lipid extraction from low-value fish sources and investigation of high-value applications
… stress was used in male Sprague-Dawley rats to test these treatments. Maternally separated rats showed depressive-like behaviours in the forced swim and open field tests. Depressive-like behaviour in the forced swim test was evaded by treatment with fluoxetine only. Anxiety-like behaviours in …
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ELECTROPHYSIOLOGICAL INVESTIGATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY IN DEAF-1 KNOCK-OUT MICE
… affected including poor performance in memory tests in human subjects. Patients with comorbid anxiety and depression demonstrated adverse memory when subject to a verbal learning test. Abnormal mutation in the human deaf1 gene has been previously reported to be associated with ID. Previous …
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