Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 250 for “"oocyte"”.
-
Genomic studies of oocyte physiology reveal mechanisms critical to oocyte competence
In vitro maturation of porcine oocytes has been intensively studied for many years. However, the in vitro maturation system is still inefficient to produce competent oocytes that can develop to viable embryos. The studies discussed in this dissertation attempt to use different techniques and …
-
The oocyte-to-embryo transition : regulation of oocyte maturation and egg activation in Drosophila
… be highly regulated to ensure that growth of the oocyte and chromosomal segregation are coordinated properly. To do this, meiosis arrests at two points to permit oocyte differentiation and coordination with fertilization. In Drosophila, the first arrest in prophase I is released by oocyte …
-
Role of oocyte-secreted factors in prevention of cumulus cell apoptosis and enhancement of oocyte developmental competence.
Paracrine factors secreted by the oocyte (oocyte-secreted factors, OSFs) regulate a broad range of cumulus cell functions. The capacity of oocytes to regulate their own microenvironment by OSFs may in turn contribute to oocyte developmental competence. The aim of this thesis was to examine whether …
-
MATERNAL DETERMINANTS OF OOCYTE AND EMBRYO QUALITY
Oocyte quality plays a critical role in establishment of pregnancies, embryo development, implantation and the health of offspring. The oocyte provides maternal factors necessary for the initial development of its embryo during the period of transcriptional silence. Despite the consistent increase …
-
SOMATIC SIGNALS REGULATING MRNA TRANSLATION IN MAMMALIAN OOCYTE.
In oocytes, resumption and completion of meiosis I are driven by post-transcriptional mechanisms on a background of repressed mRNA transcription. However, a comprehensive understanding of this regulation in higher-order mammals has been limited by challenges in isolating polysome-associated mRNAs. …
-
Steroid hormone regulation of fetal mouse oocyte development
… During the early stages of fetal development, oocytes grow in nests or clusters known as germ cell cysts. Cysts break down into individual oocytes in the perinatal period and become enclosed by somatic pregranulosa cells to form primordial follicles. Steroid hormones have been shown by numerous …
-
Paxillin is a Novel Regulator of Xenopus Oocyte Maturation
Oocyte maturation is triggered by steroids in a transcription-independent fashion that involves an unusual positive feedback loop whereby MOS (a germ cell specific Raf) activates MEK1, which in turn activates ERK2. ERK2 then acts back on MOS to enhance its expression resulting in amplification of …
-
Studying factors influencing meiosis progression in the mouse oocyte
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
-
Dynamic relocalization of maternal transcripts during oocyte meiotic maturation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
-
Analysis of Oocyte Quality in the Rhesus Macaque (Macaca mulatta)
… reproductive technologies (ART), such as oocyte in vitro maturation (IVM) and in vitro fertilization (IVF). Although many of these 'high-tech' solutions have not yet been proven viable for pragmatic wildlife conservation, basic research and development of these emerging tools can provide …
-
The Blood-Oocyte Barrier: Morphological Evidence Implicating The Zona Pellucida
<p>A developing oocyte is capable of synthesizing "non-self" proteins recognized as foreign by the maternal immune system. Since the oocyte may be perceived as foreign it must be protected from interaction with the immune system in order for it to mature to the point of ovulation. Oocytes that …
-
Impacts of perfluorooctanoic acid on porcine oocyte health and competence
The oocyte is the female gamete and develops within ovarian follicles and has intimate connection with the ovary, the ovarian blood supply, and the follicular fluid of antral follicles. Per- and polyfluoroalkylated substances are environmental toxicants that have been detected in the follicular …
-
EGFR Signaling Is Necessary for Gonadotropin-Induced Steroidogenesis and Oocyte Maturation
… female fertility, including steroidogenesis, oocyte maturation, and subsequent ovulation. Studies were designed to examine the LH-induced signaling pathways that regulate ovarian steroidogenesis, as well as the subsequent role of steroids and their receptors on oocyte and follicle development. …
-
Context Dependent Regulation of Dicer Function During Oocyte-to-Embryo Transition
… residues of the GRARR sequence disrupts the oocyte-to-embryo transition with defects manifesting primarily during anaphase I. Furthermore, these mutations also result in the loss of maternal 26G endo-siRNAs, while miRNAs remain unperturbed. I find that in vitro synthetic asymmetric …
-
Oocyte differentiation is genetically dissociable from the meiotic program in mice
… During oogenesis, growth and differentiation of oocytes are closely coordinated with initiation and progression through meiosis. In mammals, the timing of meiotic initiation is sexually dimorphic, with only ovarian and not testicular germ cells initiating meiosis during fetal development. …
-
Supplementing IL6, IL11, and LIF to Improve Cultured Bovine Oocyte Competency
… as post-transfer survival. Media formulations, oocyte quality, and inferior expression of needed transcripts are all causes of this reduced developmental potential commonly present in in vitro-produced (IVP) bovine embryos. Recently our lab has confirmed interleukin-6 as an embryokine whose …
-
MicroRNA expression and function during porcine oocyte maturation and early embryonic development
<p>Understanding oocyte maturation and embryo development in the pig is essential to improving farm animal reproduction efficiency. Many reproductive tissues are associated with a high degree of transcriptional and translational turnover that may be in part regulated by non-coding RNA such as …
Page 1 of 13