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Showing 1 to 20 of 255 for “"one-pot"”.
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One pot synthesis of metal, carbides and polymeric aerogels
<p>"Ultra-low density, three-dimensional assemblies of nanoparticles are referred to as aerogels, and typically are derived from supercritical fluid (SCF) drying of wet-gels. Aerogels are generally fragile materials, but that issue has been addressed successfully by X-aerogels, in which the …
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Phosphate Tether-Mediated, One-Pot Metathesis Processes: Application in Small Molecule Synthesis
… Additionally, a phosphorodiamidite coupling and one-pot, sequential RCM/CM/chemoselective hydrogenation sequence was developed to obtain the final molecule in 9 steps from dienediol. The reported versatile three-step, one-pot, sequential RCM/CM/chemoselective protocol in THL was further optimized …
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Fluorous assisted one-pot oligosaccharide synthesis and chemical synthesis of homogeneous heparan sulfate proteoglycan
… in details. Pre-activation based iterative one-pot synthesis greatly accelerated the oligosaccharide assembly process. To further improve the overall synthetic efficiency, we developed a new method which was described in Chapter 2. This new method combines one-pot synthesis and fluorous …
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Exploring Enantioselective and Multicomponent One-Pot Reactions Utilizing Alkynes as Linchpins Toward Biologically Active Molecules
… and the Nazarov cyclization, in new efficient one-pot methodologies can help to expand the scope of reactions available to make such molecules. Using proprochiral and high energy starting materials like alkynes can afford reactive intermediates that can then undergo further transformations in …
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One-Pot Synthesis of meta-Substituted Phenols via Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling and Oxidation
… synthesis of meta-substituted phenols in one pot, in good to excellent yield. A Pd2+ source is the catalyst for both steps of the synthesis, which includes a cross-coupling reaction between -chlorocyclohexenones with boronic acids, followed by aerobic oxidation of the resulting enone. This …
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Producing Enantiopure Secondary Alcohols via a Silylation based Kinetic Resolution and a One-Pot Polishing Sequence
… enantiopure compounds through a sequential one-pot polishing procedure and through kinetic resolutions via silylation and desilylation. Chapter 2 highlights how we have combined a moderately selective asymmetric reaction (either a reduction or allylation) with a kinetic resolution (via …
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One-Pot catalysis and multicomponent cascade reactions for the stereoselective synthesis of Pyrrolidine and indole derivatives
… de nuevos procesos multicatalíticos en cascada "one-pot" y procesos multicomponente para la síntesis de compuestos heterocíclicos. Esta memoria se ha dividido en dos capítulos. En el Capítulo 1, se describen nuevas síntesis de derivados de pirrolidina a través de procesos "one-pot" en cascada …
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One-pot synthesis and characterisation of alkyl functionalised silicon nanoparticles, using an inverse micelle based method.
… to be true in the case of these particles. The one-pot chemical synthesis method for alkyl terminated SiNPs investigated and reported here is simple, cheap and easily scalable. In addition, toxic reagents involved in other contemporary synthesis methods for similar particles are not required. …
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The Multicomponent Synthesis of Pyrroles from Cylcopropane S Using a One Pot Pd(0) Catalyzed Dehydrocarbonylation Protocol
Previous work done by the Kerr group has shown that tetrahydro-1,2-oxazines can be efficiently synthesized using a three component coupling reaction between a hydroxylamine, aldehyde and cyclopropane diester. This affords the desired heterocycle efficiently with a wide variety of substitution. When …
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Biological Evaluation Of The Vaccine Candidate Tf-Ps A1 And A One-Pot Multicomponent Coupling/cyclization For Natural Product Herbicide (±)-Thaxtomin A
… OF THE VACCINE CANDIDATE TF-PS A1 AND A ONE-POT MULTICOMPONENT COUPLING/CYCLIZATION FOR NATURAL PRODUCT HERBICIDE (±)-THAXTOMIN A</p> <p>By </p> <p>JEAN PAUL BOURGAULT</p> <p>August 2015</p> <p>Advisor: Prof. Peter R. Andreana </p> <p>Major: Chemistry (Organic) </p> <p>Degree: Doctor of …
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Studies in asymmetric synthesis: I. the asymmetric α-alkylation of N,N-dimethylhydrazones II. the asymmetric aldol-Tishchenko reaction of (S)-tert-butanesulfinyl imines for the introduction of 2, 3, 4 and 5 new chiral centres in one pot
… Part 1 The asymmetric α-alkylation of ketones is one of the most fundamental yet challenging transformations in organic chemistry. Recently a new methodology to furnish enantiomerically enriched α-alkylated ketones was developed within the McGlacken group using N,N-dimethylhydrazones as …
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Development of an organo-and enzyme-catalysed cascade reaction
This thesis describes the development of a novel one-pot reaction (Scheme 1). The reaction combines organo- and enzyme-catalysis in an aldol/aldol cascade for the first time. The bicatalytic, three-component assembly involves two aldol reactions: an organocatalysed reaction and an aldol reaction …
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Multi-component Reactions Initiated via Sonogashira Coupling
… sequence can be performed in a one-pot fashion, providing a straightforward access to push-pull chromophores. By applying acid chlorides instead of arylbromides, it was possible to synthesize ynones that are highly reactive and valuable intermediates. Furthermore, we succeeded in …
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Adventures in polyene chemistry
… been written on cross-coupling chemistry but none survey the literature of one pot, multi C(sp2)-C(sp2) bond couplings involving alkene reaction partners. Chapter 1 is a comprehensive review of the published work in this field. Specifically, this review covers published examples of one pot, 2-, …
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Adventures in polyene chemistry
… been written on cross-coupling chemistry but none survey the literature of one pot, multi C(sp2)-C(sp2) bond couplings involving alkene reaction partners. Chapter 1 is a comprehensive review of the published work in this field. Specifically, this review covers published examples of one pot, 2-, …
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C2-Amidoglycosylation With Glycal Donors for the Synthesis of 2-N-Acylamino-2-Deoxypyranosides. Development, Scope, and Mechanism
A one-pot C2-amidoglycosylation reaction for the synthesis of 2-N-acylamino-2-deoxypyranosides from glycal donors has been developed. In the reaction, activation of glycal donor by a sulfoxide and triflic anhydride followed by regio- and stereoselective transfer of an amide nucleophile generates an …
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Synthesis and Antiviral Evaluation of Some 3'-Carboxymethyl-3'-deoxyadenosine Derivatives
… adenosine (4) was accomplished via a novel one-pot method employing 5'-activation (TosCl) followed by efficient nucleophilic displacement with tetramethylguanidinium azide. Compound 4 was converted to a 5'-[(N-methylcarbamoyl)amino] derivative (5) via one-pot reduction/acylation employing …
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Engineering novel tandem reactions using organometallic catalysts and (metallo)enzymes
… has been and continuous to be a push to develop one-pot reactions, within which several catalysts from the same or disciplines are combined to catalyze numerous chemical steps and yield enantiopure products in high yield and selectivity. While this strategy is widespread in the respective fields …
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Developing and Understanding Iridium-Catalysed Arene Borylation
… key issues associated with the methodology. The one-pot conversion of aryl boronates, generated by C-H borylation, to other functionality has been one area of interest. However, reactions typically require a change in reaction solvent to make this possible. This thesis describes a one-pot, single …
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1,1-enediamines and β-substituted enamines in heterocyclic synthesis
… ~-substituted enamines were prepared by a 'one pot synthesis' in which a l,l-enediamine presumably acts as an intermediate. These enamines, various substituted crotonamides and propenamides, were made by using two different orthoesters, various secondary and primary amines and …
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