Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"oncostatin M"”.
-
Negative Regulation der Oncostatin M-vermittelten Signaltransduktion
… In this study, the role of the specific Oncostatin M receptor (OSMR) in the SOCS3 mediated inhibition of the OSM pathway is analyzed. The obtained results point to a new mechanism of the inhibitory action of SOCS3. We could show that OSM induces the expression of SOCS3 much more …
-
Die Regulation der Expression des humanen Oncostatin-M-Rezeptors durch Januskinasen
The oncostatin M receptor (OSMR) is part of a heterodimeric receptor complex which mediates signal transduction of the pleiotropic cytokine OSM. Like other cytokine receptors, the OSMR does not contain intrinsic kinase activity and therefore signalling events are mediated by members of the family …
-
Charakterisierung der Oncostatin-M-vermittelten STAT5-Aktivierung : Beitrag des Rezeptorkomplexes und der Januskinasen
Most cytokines and growth factors act on their target cells by binding specific receptors on the cell surface and activation of an intracellular signal cascade. OSM, a pleiotropic cytokine, belongs to the IL-6 family of cytokines and signals through a receptor complex containing the subunits gp130 …
-
Effects of Oncostatin-M Receptor overexpression on cervical squamous cell carcinoma cells and their extracellular vesicles
… order to develop effective novel therapies. The oncostatin-M receptor (OSMR) frequently undergoes copy-number gain and overexpression in squamous cell carcinomas (SCC) at multiple sites, consistently associated with an adverse overall survival independent of tumour stage. OSM-OSMR signalling …
-
Bedeutung von Interleukin-6, Oncostatin M und Interleukin-31 für die biochemische und immunologische Barrierefunktion der Haut
… the effect of interleukin-6 (IL-6) and oncostatin M (OSM) on the expression of MRP-1, -3, -4 and -5 in normal human epidermal keratinocytes and primary dermal fibroblasts. Using real-time PCR, RT-PCR, cDNA microarray, immunostaining and efflux assays we found that IL-6 in combination …
-
Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment
… this copy number gain correlated with Oncostatin M receptor (OSMR) overexpression and sensitised these cells to Oncostatin M (OSM) leading to increased Signal transducer and activator of transcription 3 (STAT3) phosphorylation, cell migration, invasion and proangiogenic signalling. The …
-
Funktion der Protein-Tyrosin-Phosphatase SHP2 bei der Interleukin 6 vermittelten Akutphase - Genregulation und T-Zell-Migration
… also attenuates gene induction mediated by the oncostatin M and leukemia inhibitory factor receptor complexes, which both contain gp130 as the shared domain. In the second part, it was shown that a T-cell line migrates chemotactically to IL-6. Probably the migration is caused by a cross talk …
-
Characterising the crosstalk between pancreatic fibroblasts and group 2 innate lymphoid cells in pancreatic homeostasis, inflammation, and neoplasia
… factors promoted fibroblast proliferation, while oncostatin M production by activated ILC2s might be responsible for inducing apoptosis in *Col15a1<sup>+</sup>* fibroblasts. This ILC2-dependent signalling axis was found to promote fibroblast progenitor proliferation in mouse models of …
-
Insulin resistance in cancer cachexia and metabolic syndrome
… pro-inflammatory mediators IL-1β, IL-8, CCL2, Oncostatin M (OSM) and microsomal prostaglandin E2 synthase (mPGES1), and of the anti-inflammatory mediator IL-10. Moreover, the synergism between insulin and LPS enhanced the induction provoked by LPS in IL-1β, IL-8, IL-6, CCL2 and TNF-α gene. When …
-
Novel mechanism in astrocyte gene regulation and function
… cells. In addition, activation of STAT3 by oncostatin M induced YKL-40 expression in astrocytes. Interestingly, STAT3 activated YKL-40 expression via its binding site located in the YKL-40 proximal promoter, whereas direct NFI-X binding had not been detected. Surprisingly, NFI-X and STAT3 …