Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"oncoprotein"”.
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Chromatin Regulators of MYC Oncoprotein Activity in Cancer
The MYC oncoprotein is a key contributor to the development of virtually all cancer types. MYC is known as a global regulator of transcription that controls diverse physiological and oncogenic functions. Though there are 35 yearsâ worth of research on this protein, mechanistic understanding and …
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Targeting the N-myc oncoprotein using nanobody technology
The myc family of oncogenic transcription factors, which includes c-myc, N-myc and L-myc, control major cellular processes such as proliferation and differentiation by integrating upstream signals and orchestrating global gene transcription. They do this largely through dimerising with Max, which …
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Studies on Taxol Resistance Induced by HBx Viral Oncoprotein
There is increasing evidence since the effective chemotherapeutic potential of taxol has been shown in a variety ofcancers such as ovarian,breast and lung.However,chemotherapy with taxol often fails due to resistance of hepatocellular carcinoma (HCC). I attempted to determine the effect of taxolon …
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Characterizing ALCAM as an oncoprotein and immunotherapeutic target in neuroblastoma
… (ChIP)-sequencing data for the oncoprotein MYCN showed binding of MYCN to the ALCAM promoter. We used Promoter Capture-C data and discovered a region approximately 10 kb upstream of the ALCAM promoter that was predicted to be an enhancer. Using luciferase reporter vectors and the …
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Targeting Protein Degradation to Uncover Novel Oncoprotein Drivers of Acute Leukemia
… be applied to currently undruggable targets and oncoproteins. In this paradigm, small molecule degraders (either Proteolysis Targeting Chimera (PROTAC) or Molecular Glue (MG)) redirect the cell’s endogenous ubiquitin proteasome system and induce ubiquitination of the target protein or non-native …
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Subcellular Localization of Human T-cell Leukemia Virus Type 1 Tax Oncoprotein
<p>Human T-cell Leukemia Virus Type 1 (HTLV-1) is a transforming retrovirus that gives rise to Adult T-cell Leukemia (ATL) and a variety of other subneoplastic conditions such as HTLV-Associated Myelopathy/Tropical Spastic Paraperesis (HAM/TSP). In ATL, the transformation and immortalization of …
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Study of the DNA Damage Complexes Within the HTLV-1 Tax Oncoprotein Interactome
… paraparesis (HAM/TSP). Tax is a virally encoded oncoprotein that is involved in HTLV-1 mediated cellular transformation. It has been hypothesized that Tax induces genomic instability via repression of the cellular DNA damage repair response. Our laboratory has previously shown that the …
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Isolation and Functional Mapping of Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein DNA-Damage Complexes
<p>Human T-cell Leukemia Virus Type 1 (HTLV-1) is a transforming retrovirus which causes Adult T-cell Leukemia (ATL) and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Cellular transformation can be caused by a single viral <em>trans</em>-activating protein, Tax. Tax may …
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Local or Systemic Antibody-Targeted Sting Activation Drives Pro- Inflammatory Stromal Metabolic Changes and Downregulates c-MYC Oncoprotein
<p>The past decade has witnessed remarkable advances in the field of cancer immunotherapy. Immune checkpoint blockade (ICB) has emerged as a cornerstone, achieving long-lasting tumor regression in several types of cancer. However, its effectiveness is often limited, particularly in certain tumor …
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Investigating the role of the Epstein-Barr virus-encoded oncoprotein, latent membrane protein 1, in cell transformation in vitro
… protein 1 (LMP1) is the major transforming oncoprotein encoded by Epstein-Barr virus (EBV) and is known for its ability to transform B cells, epithelial cells and rodent fibroblasts in vitro. When expressed in Madin-Darby Canine Kidney (MDCK) epithelial cells, LMP1 induces an …
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Myxoid Liposarcoma: Models and Mechanisms of Sarcomagenesis and Response to Radiation Therapy
… translocation that produces a fusion oncoprotein, FUS-CHOP. This cancer is remarkably sensitive to radiotherapy and exhibits a unique pattern of extrapulmonary metastasis. However, the mechanism for its radiosensitivity is unknown. In order to further understand the biological …
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Proteogenomic Insights Into The Nature Of Chemoresistance In Chronic Myelogenous Leukemia
… (BCR) chromosome 22, resulting in the BCR-ABL oncoprotein. BCR-ABL is a constitutively active tyrosine kinase that regulates cell growth and differentiation, leading to uncontrolled cell proliferation by deregulating downstream signaling pathways.
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Mechanism of Human Papillomavirus E6-Mediated Repression of P53-Target Gene *Transcription
… a new paradigm for human papillomavirus (HPV) E6 oncoprotein-mediated repression of human p21 WAF1 cyclin-dependent kinase inhibitor gene transcription, independent of its well known role to promote the ubiquitination and degradation of p53. Using both high-risk and low-risk HPV E6 oncoproteins, …
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Transcriptional Regulation of Chicken Apolipoprotein A-I Gene Expression
… of the oncogenic transformation induced by v-Jun oncoprotein. In the past several years, extensive efforts have been made to identify such genes. Several target genes have been identified that are specifically associated with the v-Jun induced transformation phenotype in chicken embryo fibroblasts …
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Prolyl Isomerase Pin1 Is a Conditional Tumor Suppressor
… binds to and promotes the degradation of the oncoprotein c-Myc. Pin1 and the SCF<sup>Cdc4</sup> ubiquitin ligase recognize a “phosphodegron” sequence in c-Myc, which leads to its ubiquitination and degradation by the 26 S proteasome. Since cyclin E is another oncoprotein regulated …
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Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins
… by RUNX1 and its fusion derived leukaemogenic oncoproteins in primary fibroblasts. My work showed that RUNX1 induces a strong senescence-like response in murine and human primary fibroblasts that requires intact DNA binding, CBFB interaction and C-terminal transcriptional activation/repression …
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Role of Spz1 in HPV-mediated carcinogenesis
… transformation are not well understood. The HPV oncoprotein E7 plays a central role in viral survival and proliferation in host cells and it is partly responsible for the transformation of cells infected with HPV. Its most studied role is inducing a proliferative state in epithelial cells via …
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