Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"oncolytic viruses"”.
-
Role of the Innate Immune Response to DNA During Therapy with Oncolytic Viruses
Oncolytic viruses (OVs) are viruses which selectively replicate within and directly lyse cancer cells whilst sparing host tissue. This selectivity not only helps their safety profiles and minimise toxicities but also allows OVs to potentially increase their therapeutic dose over time as they …
-
Oncolytic viruses enhance long-term NK cell anti-tumor cytotoxicity through AP-1 and IRF pathway activation
… we investigated the combination of NK cells with oncolytic viruses to treat solid tumors, specifically pancreatic ductal adenocarcinoma and glioblastoma. We demonstrated that infecting tumor cells with the oncolytic adenovirus Delta-24-RGD significantly increases their susceptibility to NK cell …
-
Characterizing the Impact of Specific Genetic Mutations on Chemotherapy Resistance and the Efficacy of Oncolytic Viruses for the Treatment of Ovarian Cancer
… cancer and urgently requires new therapies. Oncolytic viruses (OV) are a strong contender. OVs interact with immune components of the TME, which can be altered due to specific genetic mutations. The present study evaluates the impact of specific tumour mutations on the response to …
-
Improving the effectiveness of oncolytic virotherapy: insights from mathematical modelling
Oncolytic viruses are viral particles that specifically infect cancer cells, while mostly preserving healthy tissues. Their use as cancer treatment has received considerable attention in recent years, but their clinical use still faces many challenges. Some of the main obstacles to the propagation …
-
Engaging Immune Cells within the Tumor Microenvironment to Enhance Efficacy of Oncolytic Virotherapy
Oncolytic viruses are particularly attractive for many of the current cancer-immunotherapeutic modalities in their capacity to simultaneously cause direct lysis of tumor cells and indirect augmentation of host anti-tumor immunity. Despite widespread interest in the direct anti-cancer activity of …
-
The Role of Anti-Viral Immune Response on the Therapeutic Efficacy of Oncolytic Virotherapy for High-Grade Gliomas
… and immune checkpoint blockade therapies. Oncolytic viruses offer a new treatment modality by selectively replicating in cancer cells and inducing anti-tumor immunity. Among these viruses, the oncolytic adenovirus Delta-24-RGD has shown safety and efficacy in clinical trials for high-grade …
-
Comparative Study of Colon Cancer Subclones Uncovers Potential Roles for AKAP7 and TP53RK in the Antiviral Response.
… for the effective treatment of cancer using oncolytic viruses (OVs). A better understanding of the pathways involved in delineating tumour cell resistance and hypersensitivity to OVs is critical in order to guide the development of new therapeutic strategies to enhance OVs. In this thesis, I …
-
Multiscale Modelling of Cancer Response to Viral Therapy
Oncolytic viruses (OV) are viruses that can replicate selectively within cancer cells and destroy them. While the past few decades have seen significant progress re- lated to the use of these viruses in clinical contexts, the degree of success of viral oncolytic therapies is currently dampened by …
-
ARMING STRATEGIES TO IMPROVE THE IMMUNOTHERAPEUTIC POTENTIAL OF ONCOLYTIC HERPESVIRUSES
Exploiting the capacity of oncolytic viruses (OVs) to selectively target and destroy tumor cells while triggering robust antitumor immune responses offers a highly promising avenue in cancer immunotherapy. Inside the wide viral repertoire for oncolytic virotherapy, Herpes simplex virus type 1 …
-
The Influence of Human Umbilical Vein Endothelial Cells in the Formation of Glioblastoma Spheroids in Three-Dimensional Microwells
… have been considered for GBM treatment such as oncolytic viruses (OVs). The studies with two-dimensional (2D) cell cultures have been used as physiological models for understanding the cellular and molecular behavior of the GBM tumors. They are also highly desirable for virus studies. However …
-
Mathematical modelling and investigation of oncolytic therapies for cancer: The role of macrophages in tumour-virus interactions
… supporting the hypothesis that replicating oncolytic viruses provide promising treatment strategies against cancer. However, the success of these viral therapies depends mainly on the complex interactions between the virus particles and the host immune cells in tumour-microenvironment. Among …
-
Combination of Oncolytic Adenoviruses, T-Cell Activation, and Blockade of Ido Metabolic Circuitry For The Treatment of Glioma
… be developed. One promising alternative is oncolytic adenovirus, Delta-24-RGD, which elicits cancer cell lysis and immunogenic cell death. In fact, Delta-24-RGD produced complete responses in 20% of recurrent glioblastoma patients through immune mechanisms that activate anti-tumor cytotoxic …
-
Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… enzymes for chemotherapeutic pro-drugs, and oncolytic viruses with some success in pre-clinical models. Despite the promise of hMSCs, previous studies have relied for the most part on xenografts derived from commercially available immortalized GBM cell lines. These cell lines poorly mimic …
-
UNDERSTANDING THE RELATIONSHIP BETWEEN ONCOLYTIC AD5 DELETED E1b55KDA LYTIC INFECTION AND P53 IN MAMMALIAN CELLS
Adenoviruses are the most commonly used in the development of oncolytic therapy. Oncolytic adenoviruses are genetically modified to selectivity replicate in and kill tumor cells. The p53 molecule is a tumor suppressor protein that responds to viral infection through the activation of apoptosis, …
-
Mechanisms of Immunogenic Cell Death in Tumour Cells Infected with Oncolytic Vaccinia Virus
Oncolytic viruses (OVs) infect and kill cancer cells whilst generating anti-tumour immune responses. The anti-tumour effect of OVs is attributed to their ability to induce immunogenic cell death (ICD) during their infection of tumour cells. The mechanisms by which ICD occurs is not well defined and …
-
The elaborate interplay of natural killer cells and vaccinia virus
… vector for heterologous antigens and an oncolytic virus for cancer therapy. VACV encodes multiple proteins that aid evasion of the host immune response. There is, however, an incomplete understanding of how this immune suppression by VACV is consistent with such a strong immune response …
-
Treatment of murine tumors with recombinant Myxoma viruses
Oncolytic viruses are designed to be novel cancer treatments that not only specifically target cancer cells, but can act as vectors to express proteins of interest within the tumor bed. Myxoma virus (MYXV), a rabbit-specific poxvirus, was evaluated as an oncolytic viral treatment for cancer in …
-
SMAC Mimetics Sensitize HIV-Infected Cells to MG1-Mediated Death
… to killing by the interferon sensitive oncolytic rhabdovirus virus MG1. Although MG1 has affinity for latently/persistently HIV-infected cells, its effectiveness and selectivity can be enhanced. To enhance killing, MG1 was combined with the pro-apoptotic molecules, second mitochondria …
-
Development and Characterization of a Recombinant Vesicular Stomatitis Virus (rVSV) for the Treatment of Glioblastoma
… life for those affected. Replication competent oncolytic viruses (OVs) have recently emerged as a possible option for treatment of high-grade gliomas. Particularly, recombinant vesicular stomatitis virus (rVSV), an enveloped, negative strand RNA virus, has shown promising results in preclinical …