Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"oncolytic virus therapy"”.
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Modeling of [¹⁸F]-FHBG in tumor and normal tissues
… treatment of tumors has led to the emergence of oncolytic virus therapy. Viruses have been engineered to preferentially target tumor cells. The efficiency and safety of this cancer treatment is dependent upon selective viral replication within cancer cells. In order for viral oncolysis to be …
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Myxoma Virus Therapy of Malignant Gliomas in Murine Syngeneic Models: Translating Barriers to Therapy
… investigation into non-traditional therapies. Oncolytic virus therapy entails the use of replication competent viruses that selectively infect, replicate and kill cancer cells. This multi-modal therapy can function to directly kill cancer cells, stimulate anti-tumour immune responses, and be …
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Inhibition of adenosinergic signaling in the tumor immune environment: the effect of combination CD73 blockade and oHSV therapy on solid tumors
<p>Oncolytic HSV (oHSV) therapy is a live virus-based immunotherapy that lyses tumor cells which release antigens and activate anti-tumor immunity. Immunotherapy-based drugs have made significant advances in treating cancer. However, unchecked immune activation can escalate to autoreactivity or …
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Effects of Penfluridol On Integrin-Fak Signaling and Tumor Cell Killing In Combination With Oncolytic Hsv In Glioblastoma
… at a transcriptional level, in combination with oncolytic herpes simplex I virus (oHSV) in a glioblastoma model. We examined the effects of oHSV on FAK signaling by looking at FAK phosphorylation at different time points post-infection and saw that FAK was activated by viral infection at earlier …