Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"oncolytic virus"”.
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CHANGES IN SUSCEPTIBILITY TO VESICULAR STOMATITIS VIRUS DURING PROGRESSION OF PROSTATE CANCER
Vesicular stomatitis virus (VSV) is an attractive oncolytic virus. Differing sensitivity to VSV oncolysis of human prostate cancer cell lines has been observed in previous experiments. The goal of my experiments was to determine the mechanisms of sensitivity and resistance to VSV.
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Engaging Immune Cells within the Tumor Microenvironment to Enhance Efficacy of Oncolytic Virotherapy
Oncolytic viruses are particularly attractive for many of the current cancer-immunotherapeutic modalities in their capacity to simultaneously cause direct lysis of tumor cells and indirect augmentation of host anti-tumor immunity. Despite widespread interest in the direct anti-cancer activity of …
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Immunotherapy for murine glioma
Oncolytic viral immunotherapy is a novel approach to cancer treatment. Viruses can directly kill cancer cells, provide antigens to dendritic cells to stimulate a T cell response, and make cancer cells express genes of immune-enhancing cytokines locally within the tumor microenvironment. We …
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Mathematical modelling and investigation of oncolytic therapies for cancer: The role of macrophages in tumour-virus interactions
… supporting the hypothesis that replicating oncolytic viruses provide promising treatment strategies against cancer. However, the success of these viral therapies depends mainly on the complex interactions between the virus particles and the host immune cells in tumour-microenvironment. Among …
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Modeling of [¹⁸F]-FHBG in tumor and normal tissues
… treatment of tumors has led to the emergence of oncolytic virus therapy. Viruses have been engineered to preferentially target tumor cells. The efficiency and safety of this cancer treatment is dependent upon selective viral replication within cancer cells. In order for viral oncolysis to be …
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ASSESSING AN M MUTANT VESICULAR STOMATITIS VIRUS FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME BY DETERMINING APOPTOTIC MECHANISMS AND ANTIVIRAL RESPONSE
Vesicular stomatitis virus (VSV) is a potential oncolytic virus for treating glioblastoma multiforme (GBM), an aggressive brain tumor. Matrix (M) protein mutants of VSV have shown greater selectivity for killing GBM cells versus normal brain cells, compared to VSV with wild-type M protein. The goal …
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Multiscale Modelling of Cancer Response to Viral Therapy
Oncolytic viruses (OV) are viruses that can replicate selectively within cancer cells and destroy them. While the past few decades have seen significant progress re- lated to the use of these viruses in clinical contexts, the degree of success of viral oncolytic therapies is currently dampened by …
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Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
… uses an improved Modified Vaccinia Ankara poxvirus that we developed to express mesothelin to the murine immune system to treat pancreatic tumors and create an anti-cancer vaccine. PCR, Flow Cytometry, and Western Blot confirmed virus construction, purity, and protein expression. Our …
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Role of Hypoxia-inducible Factor in Kidney Cancer
… ccRCC cells. We also demonstrate that the picornavirus EMCV (Encephalomyocarditis virus) efficiently destroys ccRCC tumour cells in an NF-kappaB- and HIFalpha-dependent manner both in vitro and in a mouse xenograft model. This work provides pre-clinical evidence for the potential use of EMCV in an …
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ARMING STRATEGIES TO IMPROVE THE IMMUNOTHERAPEUTIC POTENTIAL OF ONCOLYTIC HERPESVIRUSES
Exploiting the capacity of oncolytic viruses (OVs) to selectively target and destroy tumor cells while triggering robust antitumor immune responses offers a highly promising avenue in cancer immunotherapy. Inside the wide viral repertoire for oncolytic virotherapy, Herpes simplex virus type 1 …
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Myxoma Virus Therapy of Malignant Gliomas in Murine Syngeneic Models: Translating Barriers to Therapy
… investigation into non-traditional therapies. Oncolytic virus therapy entails the use of replication competent viruses that selectively infect, replicate and kill cancer cells. This multi-modal therapy can function to directly kill cancer cells, stimulate anti-tumour immune responses, and be …
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Targeted Oncolytic Virotherapy Using Newcastle Disease Virus Against Prostate Cancer
… CaP including stem cells are imperative. Oncolytic virus (OV) therapy is a novel approach that overcomes the limitations posed by radiation and chemotherapy. Oncolytic virotherapy of cancer is based on the use of replication competent, tumor selective viruses with limited toxicity. …
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Signaling at the Tumor-Immune Interface in Glioblastoma
… tumors in response to treatment with an oncolytic virus (OV). In patient derived tumor (PDX) models in mice, mice treated with OV have increased antigen presentation, pointing to the use of OV therapy to reshape the tumor micro-environment to a more inflammatory state. Finally, tissue …
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SMAC Mimetics Sensitize HIV-Infected Cells to MG1-Mediated Death
… to killing by the interferon sensitive oncolytic rhabdovirus virus MG1. Although MG1 has affinity for latently/persistently HIV-infected cells, its effectiveness and selectivity can be enhanced. To enhance killing, MG1 was combined with the pro-apoptotic molecules, second mitochondria …
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The elaborate interplay of natural killer cells and vaccinia virus
Vaccinia virus (VACV) is a poxvirus and is the vaccine used to eradicate smallpox. It is also an expression vector for heterologous antigens and an oncolytic virus for cancer therapy. VACV encodes multiple proteins that aid evasion of the host immune response. There is, however, an incomplete …
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Sterility and immunogenicity of gamma-irradiated respiratory viruses
… sterilising doses that is highly applicable to viruses and bacteria. Our research group has developed a whole-inactivated influenza A virus (IAV) vaccine using γ-radiation (γ-Flu). IAV presents a constant pandemic threat due to the mutagenic nature of the virus and the inadequacy of current …
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The Role of Anti-Viral Immune Response on the Therapeutic Efficacy of Oncolytic Virotherapy for High-Grade Gliomas
… and immune checkpoint blockade therapies. Oncolytic viruses offer a new treatment modality by selectively replicating in cancer cells and inducing anti-tumor immunity. Among these viruses, the oncolytic adenovirus Delta-24-RGD has shown safety and efficacy in clinical trials for high-grade …
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Role of the Innate Immune Response to DNA During Therapy with Oncolytic Viruses
Oncolytic viruses (OVs) are viruses which selectively replicate within and directly lyse cancer cells whilst sparing host tissue. This selectivity not only helps their safety profiles and minimise toxicities but also allows OVs to potentially increase their therapeutic dose over time as they …
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Comparative Study of Colon Cancer Subclones Uncovers Potential Roles for AKAP7 and TP53RK in the Antiviral Response.
… for the effective treatment of cancer using oncolytic viruses (OVs). A better understanding of the pathways involved in delineating tumour cell resistance and hypersensitivity to OVs is critical in order to guide the development of new therapeutic strategies to enhance OVs. In this thesis, I …
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Dissecting the Role of ATRX in Soft Tissue Sarcoma Development and Therapeutic Response
… sensitivity to the novel clinical therapy oncolytic herpesvirus. Translation of these results to patients with ATRX mutant cancers could enable genomically-guided cancer therapeutic approaches that improve patient outcomes.</p>
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