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Showing 1 to 20 of 57 for “"oncolytic"”.
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Enhancing Oncolytic Virotherapy Using Functional Genomic Screening
The treatment of cancer patients with oncolytic vaccinia virotherapy has yielded encouraging results in early phase clinical trials, but there are yet unexplored opportunities for improving this therapy that could lead to even better outcomes for patients. To this end, we harnessed the power of …
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ARMING STRATEGIES TO IMPROVE THE IMMUNOTHERAPEUTIC POTENTIAL OF ONCOLYTIC HERPESVIRUSES
Exploiting the capacity of oncolytic viruses (OVs) to selectively target and destroy tumor cells while triggering robust antitumor immune responses offers a highly promising avenue in cancer immunotherapy. Inside the wide viral repertoire for oncolytic virotherapy, Herpes simplex virus type 1 …
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Walleye dermal sarcoma virus Orf C: a potential oncolytic therapy
… Orf C targets may be useful in developing future oncolytic therapies.
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Improving the effectiveness of oncolytic virotherapy: insights from mathematical modelling
Oncolytic viruses are viral particles that specifically infect cancer cells, while mostly preserving healthy tissues. Their use as cancer treatment has received considerable attention in recent years, but their clinical use still faces many challenges. Some of the main obstacles to the propagation …
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Targeted Oncolytic Virotherapy Using Newcastle Disease Virus Against Prostate Cancer
… CaP including stem cells are imperative. Oncolytic virus (OV) therapy is a novel approach that overcomes the limitations posed by radiation and chemotherapy. Oncolytic virotherapy of cancer is based on the use of replication competent, tumor selective viruses with limited toxicity. …
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Oncolytic adenovirus vectors for nitroreductase suicide gene therapy of prostate cancer
… of Birmingham gene therapy group constructed two oncolytic adenovirus vectors, CRAd-NTR and vNR6, both of which contained the E1B-55K deletion and expressed the transgene nitroreductase for combined oncolytic virotherapy and enzyme/prodrug gene therapy. The latter of these two vectors, vNR6, …
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Engaging Immune Cells within the Tumor Microenvironment to Enhance Efficacy of Oncolytic Virotherapy
Oncolytic viruses are particularly attractive for many of the current cancer-immunotherapeutic modalities in their capacity to simultaneously cause direct lysis of tumor cells and indirect augmentation of host anti-tumor immunity. Despite widespread interest in the direct anti-cancer activity of …
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Enhancing efficacy of oncolytic myxoma virus and adoptive T cell therapy against tumors
… fighting cancers. Another attractive strategy is oncolytic viral therapy, the use of cancer-specific viruses to target and kill cancer cells. Combining immunotherapies and viral therapies has shown synergistic effect in the past. Most of our work focused on myxoma virus, a rabbit poxvirus, which …
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Role of the Innate Immune Response to DNA During Therapy with Oncolytic Viruses
Oncolytic viruses (OVs) are viruses which selectively replicate within and directly lyse cancer cells whilst sparing host tissue. This selectivity not only helps their safety profiles and minimise toxicities but also allows OVs to potentially increase their therapeutic dose over time as they …
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Mechanisms of Immunogenic Cell Death in Tumour Cells Infected with Oncolytic Vaccinia Virus
Oncolytic viruses (OVs) infect and kill cancer cells whilst generating anti-tumour immune responses. The anti-tumour effect of OVs is attributed to their ability to induce immunogenic cell death (ICD) during their infection of tumour cells. The mechanisms by which ICD occurs is not well defined and …
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Phase I Clinical Trial of Recombinant Oncolytic Newcastle Disease Virus for Intracranial Meningioma
Meningioma is one of the most commonly diagnosed intracranial tumors in dogs and humans. Treatment failures resulting in local recurrence and death remain common in tumors of high grade, prompting a need for additional therapeutic options that are both effective and affordable. Genetic modification …
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Evaluation of Adoptive T Cell Therapy and Oncolytic Virotherapy for Treatment of Brain Tumors
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2013-01-22T11:00:26Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Neuroscience Program Dissertations (ID: 630) No. of bitstreams: 3 Thomas_Diana.pdf.txt: 257425 bytes, checksum: …
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UNDERSTANDING THE RELATIONSHIP BETWEEN ONCOLYTIC AD5 DELETED E1b55KDA LYTIC INFECTION AND P53 IN MAMMALIAN CELLS
… are the most commonly used in the development of oncolytic therapy. Oncolytic adenoviruses are genetically modified to selectivity replicate in and kill tumor cells. The p53 molecule is a tumor suppressor protein that responds to viral infection through the activation of apoptosis, which is …
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Oncolytic viruses enhance long-term NK cell anti-tumor cytotoxicity through AP-1 and IRF pathway activation
… we investigated the combination of NK cells with oncolytic viruses to treat solid tumors, specifically pancreatic ductal adenocarcinoma and glioblastoma. We demonstrated that infecting tumor cells with the oncolytic adenovirus Delta-24-RGD significantly increases their susceptibility to NK cell …
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Mathematical modelling and investigation of oncolytic therapies for cancer: The role of macrophages in tumour-virus interactions
… supporting the hypothesis that replicating oncolytic viruses provide promising treatment strategies against cancer. However, the success of these viral therapies depends mainly on the complex interactions between the virus particles and the host immune cells in tumour-microenvironment. Among …
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Effects of Penfluridol On Integrin-Fak Signaling and Tumor Cell Killing In Combination With Oncolytic Hsv In Glioblastoma
… at a transcriptional level, in combination with oncolytic herpes simplex I virus (oHSV) in a glioblastoma model. We examined the effects of oHSV on FAK signaling by looking at FAK phosphorylation at different time points post-infection and saw that FAK was activated by viral infection at earlier …
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Combination of Oncolytic Adenoviruses, T-Cell Activation, and Blockade of Ido Metabolic Circuitry For The Treatment of Glioma
… be developed. One promising alternative is oncolytic adenovirus, Delta-24-RGD, which elicits cancer cell lysis and immunogenic cell death. In fact, Delta-24-RGD produced complete responses in 20% of recurrent glioblastoma patients through immune mechanisms that activate anti-tumor cytotoxic …
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The Role of Anti-Viral Immune Response on the Therapeutic Efficacy of Oncolytic Virotherapy for High-Grade Gliomas
… and immune checkpoint blockade therapies. Oncolytic viruses offer a new treatment modality by selectively replicating in cancer cells and inducing anti-tumor immunity. Among these viruses, the oncolytic adenovirus Delta-24-RGD has shown safety and efficacy in clinical trials for high-grade …
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Immunotherapy for murine glioma
Oncolytic viral immunotherapy is a novel approach to cancer treatment. Viruses can directly kill cancer cells, provide antigens to dendritic cells to stimulate a T cell response, and make cancer cells express genes of immune-enhancing cytokines locally within the tumor microenvironment. We …
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