Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"oncogenic signalling"”.
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Regulation of sphingosine kinase 1 oncogenic signalling by calcium and integrin binding proteins
… By catalysing formation of the versatile signalling molecule sphingosine 1-phosphate (S1P), SK1 has clear roles in a wide range of cellular processes. The dysregulation of SK1 signalling has been broadly implicated in the pathogenesis of various cancer types, although better understanding …
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Oncogenic KRAS drives heterogeneity in metabolic and signalling pathways through genetic and non-genetic mechanisms
… is often an activating mutation in key cell signalling hub KRAS. Despite extensive research into PDAC and KRAS, the impact of both genetic and non-genetic variability during the earliest steps of carcinogenesis are scantly described. We hypothesise that both forms of heterogeneity might alter …
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Targeting the B-Cell Receptor in Diffuse Large B-Cell Lymphoma
… receptor of immunoglobulin in tandem with the signalling adapters CD79A and CD79B. Over the last 2 decades, the importance of signals emanating from the BCR have gained prominence in how we understand oncogenic signalling in DLBCL. Multiple agents targeting BCR signalling have been tried in …
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Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.
Bone morphogenetic protein (BMP) signalling plays key roles in skin development and also possesses a potent anti-tumour activity in postnatal skin. To study mechanisms of the tumour-suppressive role of BMPs in the skin, a transgenic (TG) mouse model was utilized, in which a transgenic expression of …
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Investigating the clinicopathological spectrum and associated genetics of colorectal carcinoma in young (<60 years of age) patients in the Western Cape Province
… in the subregion. To investigate driver genes, oncogenic signalling pathways and spectrum of pathogenic variants, we retrospectively identified 197 CRC cases over a 5 year period. Thirty-two mismatch repair deficient (dMMR) cases, without known germline variants, were investigated with …
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The effect of cAMP elevation on intracellular signalling pathways in prostate epithelial cells
Chronic IL-6 signalling contributes to the pathophysiology of many diseases including prostate cancer. Relevant to prostate cancer is the ability of the pro-inflammatory cytokine IL-6 to activate the oncogenic signalling protein STAT3, thus inhibition of STAT3 activation is a popular avenue of …
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Identification and validation of new therapeutic targets for squamous cell lung cancer
… impact on cell fitness, survival, and downstream signalling. While TrkB.T1 was shown to be the predominant transcript variant of the *NTRK2* gene in LUSC and other squamous cancers, both TrkB.T1 and TrkB.FL variants had a functional role in oncogenic signalling. Targeting TrkB in patients with …
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UNRAVELLING MECHANISMSOF SCHWANN CELLS IN VESTIBULAR SCHWANNOMA AND THEIR IMPACT ON HEARING LOSS.
… affecting pathways associated with migration, oncogenic signalling, and hearing loss-related genes. Because of the limited availability of human VN and VS tissues, a physiologically relevant alternative model was established through the isolation and characterization of primary rat VN-derived …
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The analysis of genetic aberrations in South African oesophageal squamous cell carcinoma patients
… (COL) and MMP genes known to play a role in oncogenic progression and membrane stiffness. GSEA and KEGG analysis indicated predominantly chemokine/cytokine pro-inflammatory enriched pathways. Immunohistochemistry staining showed 10 out of 13 of the samples had no detectable levels of MUC3A …
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Cellular Determinants Of AURKA Degradation By Small Molecule Proteolysis-Targeting Chimeras
… (PROTACs) has enhanced the field of ubiquitin signalling through advancing therapeutic targeted protein degradation (TPD) strategies and generating tools to explore the ubiquitin landscape. However, the cellular factors that modulate PROTAC activity, such as substrate characteristics and their …
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Integrative Analysis of Omics Data In Adult Glioma and Other Tcga Cancers to Guide Precision Medicine
… of a subset of cancer patients by predicting the oncogenic signalling and specific drug targets encoded by these fusion genes.</p> <p>Taken together, the translational genomic research I have conducted during my Ph.D. study will shed new light on precision medicine and contribute to the cancer …
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Characterising the effects of ACK-mediated phosphorylation on the Class IA PI3-Kinase regulatory isoforms
… of many malignancies. ACK orchestrates its oncogenic activity through interactions with diverse proteins including the androgen receptor, the oestrogen receptor and WW domain containing oxidoreductase. Despite enormous progress in recent years, much remains to be learnt concerning ACK's role …
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The biological effects of HIV-1 Nef on the development of B-cell Lymphoma
… demonstrates that the virus can have direct oncogenic effects, often through the action of specific virally-encoded proteins. The latter can act alone or collaboratively with cellular proteins, as well as with oncoproteins of established oncogenic viruses such as the Kaposi's …
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Elucidating oncogenic mechanisms in human B cell malignancies
… differ in their ability to control Erk signalling strength. Secondly, DLBCL is the most common haematological malignancy and although potentially curable with chemotherapy, 40% of patients still succumb from their disease. Recent exome sequencing studies have identified hundreds of …