Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"oncogenic pathway"”.
-
Investigating the clinicopathological spectrum and associated genetics of colorectal carcinoma in young (<60 years of age) patients in the Western Cape Province
… in the subregion. To investigate driver genes, oncogenic signalling pathways and spectrum of pathogenic variants, we retrospectively identified 197 CRC cases over a 5 year period. Thirty-two mismatch repair deficient (dMMR) cases, without known germline variants, were investigated with …
-
MiR-10a Regulation of Drug Response and Cancer Stem Cell Populations in Non-Small Cell Lung Carcinomas
… upon activation. Overall, this signaling pathway is under tight regulation and even slight perturbations can lead to aberrant pathway activation. In NSCLC cell lines, we found that manipulation of miR-10a results in significant changes to both mRNA and protein levels of PI3K. In the …
-
Investigating the C-terminal region of RalA: regulation through membrane dynamics and protein-protein interactions
… pharmaceutical intervention in this critical oncogenic pathway. So far, biophysical characterisation of Ral proteins has typically been carried out with truncated constructs that exclude the C-terminal ~20 residues. However, this C-terminal hypervariable region is not only the main source of …
-
Genetic analyses, protein expression, type and function with clinical and immunological correlates in human papillomavirus associated head and neck neoplasia
… tobacco smoke, alcohol) all play a part in the pathway and susceptibility to oncogenesis. Analogous to uterine cervix disease, HPV-associated cancers involve wild-type TP53 whilst HPV negative tumours often have mutations in this gene. As most patients with HPV associated OPSCC present at an …
-
The c-Myc/TBX3/nucleolin/Hsc70 signalling axis in breast cancer
… mechanisms that regulate and mediate its oncogenic activity may reveal more amenable anti-cancer drug targets. This project therefore aimed to (1) identify signalling molecules that upregulate TBX3 expression in MCF-7 breast cancer cells as well as (2) identify and characterize protein …
-
Substrate Identification of an Oncogenic Kinase: Elucidating the Pathogenesis of a Rare Liver Cancer
… it is not currently known whether the oncogenic kinase that results from this fusion event, DNAJB1- PRKACA, phosphorylates the same substrates as PRKACA, the protein product of PRKACA. While the total phosphoproteome of a cancer can implicate critical pathway changes in the tumor versus …
-
The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… a wide range of cancers where it impacts several oncogenic processes including bypass of senescence, apoptosis and anoikis, promotion of proliferation, tumour formation, angiogenesis, invasion, and metastatic capabilities. In breast cancer, TBX3 is overexpressed in a subset of patient tissues and …