Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 591 for “"oncogenic"”.
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Global characterization of oncogenic kinase signaling
Aberrant activation and expression of the proto-oncogene Src have been observed in various human malignancies. Despite major advancements in kinase-targeted cancer therapies, targeting Src has only achieved limited clinical success, thus highlighting the urgent need to better understand the complex …
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Novel Oncogenic Drivers in Pediatric Gliomagenesis
… in older children, suggesting a small number of oncogenic mutations are required in infant tumors. These findings, coupled with the observation that infants have a better prognosis than non-infants, make infant NBS tumors a distinct subgroup of pHGG. NTRK gene fusions also occur in pediatric …
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Oncogenic Pathways and Molecular Prognostics in Neuroblastoma
Neuroblastoma is an embryonal malignancy that accounts for 15% of all cancer related deaths amongst children. Although the overall survival of patients has been improving over the last decades, the high-risk neuroblastoma patients have a survival rate of <50%. Using gene expression microarrays we …
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Protein-based Degrader Strategies against Oncogenic RAS
Targeted therapies have emerged as a promising cancer treatment strategy by inhibiting proteins specific to cancer cells while preserving healthy cells. RAS proteins play a crucial role in cancer development and are associated with increased tumor growth and invasion. Mutations in RAS genes, …
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Hypoxic gene regulation and oncogenic pathways in neuroblastoma
Neuroblastoma patients show remarkable clinical heterogeneity, with courses ranging from spontaneous regression to fatal tumor progression despite intense multi-modal treatment. Previous studies have shown that hypoxia pushes neuroblastoma cells towards a more immature phenotype, which correlates …
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Oncogenic Kras and Telomere Biology In Crc Progression
… to advanced CRC. </p> <p>Human CRCs carrying oncogenic mutations in the <em>KRAS</em> oncogene, henceforth referred to as KRAS*, exhibit a 25% higher propensity for developing liver metastases. Similarly, in our CRC mouse model, engineered with an inducible <em>Kras</em>* transgene and …
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Regulation of the oncogenic PIM1 kinase by SUMOylation
PIM1 (Proviral Integration site for Murine leukemia virus site 1) is a constitutively active serine/threonine protein kinase that is induced physiologically by the JAK-STAT and NF-κB pathways. PIM1 mediates<br/>survival signalling in cells, and contributes to the development of resistance towards …
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Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
… deacetylase, is required for efficient oncogenic transformation and tumor formation. I have found that HDAC6 expression is induced upon oncogenic Ras-induced transformation in both human somatic cells and murine fibroblasts. Conversely, murine fibroblasts deficient in HDAC6 are more …
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Elucidating oncogenic mechanisms in human B cell malignancies
… provide novel understanding of the complexity of oncogenic mechanisms in human B cell malignancies.
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Targeting oncogenic microRNAs in malignant germ cell tumours.
Malignant germ cell tumours (mGCTs) are a heterogenous group of tumours that occur primarily in the testes and ovaries but also in other anatomical sites, and affect people of all ages. It was established by the Coleman group through microRNA profiling in 2010 that all mGCTs, regardless of tumour …
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Cloning of a putative human oncogenic virus, BK
… be transformed and these viruses therefore have oncogenic potential in particular laboratory animals. Polyoma . viruses infect eukaryotic cells, and investigation thereof should allow further elucidation of eukaryotic gene expression and regulation. Members of the polyoma group which have been …
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Dissecting mechanisms and consequences of oncogenic RTK fusion signaling
… and live-cell imaging to find that EML4-ALK, an oncogenic fusion present in 5-7% of non-small cell lung cancers, suppress transmembrane RTK signaling by sequestering RTK adapter proteins including GRB2 and SOS1. Furthermore, ALK inhibition, while suppressing oncogenic signaling, simultaneously …
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Investigating mitotic vulnerabilities that arise upon oncogenic cell transformation
During mitosis, cells must accurately divide their duplicated chromosomes into two new daughter cells. This process is highly regulated and much of this regulation is centered around kinetochores. Kinetochores are large proteinaceous structures built upon centromeric heterochromatin that must form …
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Defining oncogenic determinants in prostate cancer initiation and progression
Prostate tumors harbor substantial biological heterogeneity with highly various treatment response. In recent years, the next-generation sequencing technology has enabled comprehensive genomic analysis of primary and metastatic prostate cancer and uncovered previously uncharacterized genetic …
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Mechanism of mitochondrial respiratory dysfunction by oncogenic K-Ras
… of carcinogenesis, an experimental model for oncogenic transformation without cell death was required. Already known as a strong oncogene driving transformation, oncogenic K-RasV12 was adopted to transform cultured fibroblast. When cultured Rat-2 fibroblast cells were infected with a …
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Towards Inhibition of Oncogenic RhoA Signaling using Stapled Peptides
… molecule inhibitors to many of the identified oncogenic targets, including the Ras superfamily of small GTPases. Peptide therapeutics are emerging as promising new modalities to more efficiently inhibit these "undruggable" targets. RhoA is a member of the Rho family within the Ras superfamily …
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Pan-cancer study of transcriptional responses to oncogenic somatic mutations
… long non-coding RNAs as effector molecules in oncogenic pathways. LncRNAs are long transcripts that are transcribed and processed similarly to coding messenger RNAs but lack coding capacity. However, a systematic exploration of lncRNAs as potential mediators of oncogenic mutational events in …
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Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy
<p><strong>The crucial role of microRNAs (miRNAs) in cancer pathobiology has driven the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small …
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Molecular Mechanisms Underlying Innate Immune Kinase TBK1-Driven Oncogenic Transformation
… cell death cues, enabling cells to survive oncogenic stress. The mechanistic basis of TBK1 prosurvival signaling, however, has been enigmatic. Here we show that TBK1 directly activates AKT by phosphorylation of the canonical activation loop and hydrophobic motif sites independently of PDK1 …
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Function of the PDLIM2 protein in oncogenic Wnt signalling pathways
… theme in cancer biology. Hyper activation due to oncogenic mutations and paracrine activity has been found in both colon cancer and breast cancer, and continues to evolve as a central mechanism in oncogenesis. PDLIM2, a cytoskeletal PDZ protein, is an IGF-1 regulated gene that is highly expressed …
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