Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"oncogene-induced senescence (OIS)"”.
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ONCOGENE-INDUCED ALTERED DNA REPLICATION DYNAMICS
Oncogene Induced Senescence (OIS) is a tumor suppressive barrier that blocks cell cycle permanently. OIS results from a robust DNA damage response (DDR) activation due to oncogene-induced hyper-proliferation. By performing a whole genome analysis of DNA replication dynamics occurring upon oncogene …
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Nucleolar dynamics in cellular senescence
… dynamic of nucleolar area triggered by different senescence inducers remains elusive. Besides, gene expression associated with enlarged nucleoli is not well understood. Here, I show nucleolar dynamics in different types of cellular senescence including oncogene-induced senescence (OIS), secondary …
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Predictive Reporter System for Investigating Dose Dependency in Oncogene-Induced Senescence
Oncogene-induced senescence (OIS) is a well-described autonomous tumour suppressor mechanism which removes cells harbouring oncogenic mutations from the proliferation pool. However, senescent cells remain metabolically active and express factors of the senescence-associated secretory phenotype …
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Optimisation of TrAEL-seq to study DNA damage and replication in complex and dynamic mammalian cell systems
… model of DNA replication stress and damage; oncogene-induced senescence (OIS) resulting from *HRAS<sup>G12V</sup>* overexpression. Analysis of TrAELseq replication fork movement across a time course of OIS revealed global changes in the levels of DNA replication across the genome. …
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
… of senescent cells within the liver. Senescence is an acutely tumour-suppressive, but chronically pro-tumorigenic stress-responsive cell pathway. Senescent cells signal to immunocytes through a complex secretome, to trigger their own CD4+ T-cell dependent destruction, termed senescence …