Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"oncogene-induced senescence"”.
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
… of senescent cells within the liver. Senescence is an acutely tumour-suppressive, but chronically pro-tumorigenic stress-responsive cell pathway. Senescent cells signal to immunocytes through a complex secretome, to trigger their own CD4+ T-cell dependent destruction, termed senescence …
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Predictive Reporter System for Investigating Dose Dependency in Oncogene-Induced Senescence
Oncogene-induced senescence (OIS) is a well-described autonomous tumour suppressor mechanism which removes cells harbouring oncogenic mutations from the proliferation pool. However, senescent cells remain metabolically active and express factors of the senescence-associated secretory phenotype …
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ONCOGENE-INDUCED ALTERED DNA REPLICATION DYNAMICS
Oncogene Induced Senescence (OIS) is a tumor suppressive barrier that blocks cell cycle permanently. OIS results from a robust DNA damage response (DDR) activation due to oncogene-induced hyper-proliferation. By performing a whole genome analysis of DNA replication dynamics occurring upon oncogene …
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Nucleolar dynamics in cellular senescence
… dynamic of nucleolar area triggered by different senescence inducers remains elusive. Besides, gene expression associated with enlarged nucleoli is not well understood. Here, I show nucleolar dynamics in different types of cellular senescence including oncogene-induced senescence (OIS), secondary …
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Optimisation of TrAEL-seq to study DNA damage and replication in complex and dynamic mammalian cell systems
… model of DNA replication stress and damage; oncogene-induced senescence (OIS) resulting from *HRAS<sup>G12V</sup>* overexpression. Analysis of TrAELseq replication fork movement across a time course of OIS revealed global changes in the levels of DNA replication across the genome. …
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Quantitative proteomic analysis of cellular senescence: from systems biology to targeted signaling pathways
Cellular senescence, an irreversible cell cycle arrest induced by a diversity of stimuli, has been considered as an innate tumor suppressing mechanism with implications and applications in cancer therapy. The senescence phenomenon was first associated with aging as Hayflick and colleagues observed …