Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"oncogene-addicted"”.
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INTERPLAY BETWEEN MDM2 AND TFAM REGULATES OXIDATIVE PHOSPHORYLATION IN DRUG-RESISTANT ONCOGENE-ADDICTED CANCERS
… (TKI) remain the first-line treatment for most oncogene-addicted cancers. However, prolonged exposure to TKI could lead to development of resistance. There is mounting evidence of OXPHOS dependency as a mechanism of TKI resistance, but the cause of this metabolic switch remains elusive. Here, we …
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Bim Mediates Imatinib-Induced Apoptosis of Gastrointestinal Stromal Tumors: Translational Implications
<p>Gastrointestinal stromal tumors (GISTs) are oncogene-addicted cancers driven by activating mutations in the genes encoding receptor tyrosine kinases KIT and PDGFR-α. Imatinib mesylate, a specific inhibitor of KIT and PDGFR-α signaling, delays progression of GIST, but is incapable of achieving …