Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"oncogene activation"”.
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E2F1 induction following DNA damage and oncogene activation
… pRb, is deregulated in most human cancers. Oncogenes have been shown to deregulate E2F1 through inhibition of pRB and deregulation of E2F1 is an event that occurs in most human cancers. The essential role of E2F1 in apoptosis is well documented and deregulated E2F1 can enhance drug induced …
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ONCOGENE-INDUCED ALTERED DNA REPLICATION DYNAMICS
Oncogene Induced Senescence (OIS) is a tumor suppressive barrier that blocks cell cycle permanently. OIS results from a robust DNA damage response (DDR) activation due to oncogene-induced hyper-proliferation. By performing a whole genome analysis of DNA replication dynamics occurring upon oncogene …
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Modulation of the Magnetic Properties of Aqueous Metal Ions and the Bioelectrodynamic Effects on Cancerous and Noncancerous Cells
… protein response (UPR), TNF/TRAIL, and p53 oncogene activation. Alternatively, the noncancerous cells show a significant increase in cell migration/wound healing after exposure to the treated media with no activation of apoptosis pathways.</p>
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Development of Extrachromosomal Genetic Technologies for Persistent and Tunable Expression of Therapeutic Payloads
… approaches risk insertional mutagenesis and oncogene activation, yielding unpredictable, irreversible consequences. Inspired by latent DNA viruses with genomes persisting as episomes, we developed an extrachromosomal genetic technology (EGT). Our EGT, featuring an engineered origin of …
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Defining the functions of a conserved hydrophobic domain in the ARF tumor suppressor
… genotoxic stress, ultra-violet irradiation and oncogene activation. We demonstrated that cells bearing the mutation showed decreased responsiveness to H-RasV12 induced senescence consistent with p21 deficiency. We speculate that the deficit in p21 expression is possibly caused by CtBP2 …
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Regulatio of actin cytoskeleton by TIS21 vi downregulating reactive oxygen species (ROS) in the doxorubicin-induced premature senescenc
… is induced by DNA damage, telomere shortening or oncogene activation. During cellular senescence BTG2 is stabilized in response to telomere dysfunction. Doxorubicin is an effective anticancer drug that belongs to a class of anthracyclines and a commonly used inducer of DNA damage. Here, we show …
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Quantitative proteomic analysis of cellular senescence: from systems biology to targeted signaling pathways
… finite number of cell divisions in cell culture. Oncogene activation acting to potentiate or overstimulate normal growth signaling is a hallmark of cancer. However, in “normal” cells oncogene activation does not lead to transformation, but instead provokes cellular senescence. One characteristic …
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Molecular Mechanisms Underlying Innate Immune Kinase TBK1-Driven Oncogenic Transformation
… of host defense mechanisms. The pathological activation of TBK1 in cancer can overcome programmed cell death cues, enabling cells to survive oncogenic stress. The mechanistic basis of TBK1 prosurvival signaling, however, has been enigmatic. Here we show that TBK1 directly activates AKT by …
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Predictive Reporter System for Investigating Dose Dependency in Oncogene-Induced Senescence
Oncogene-induced senescence (OIS) is a well-described autonomous tumour suppressor mechanism which removes cells harbouring oncogenic mutations from the proliferation pool. However, senescent cells remain metabolically active and express factors of the senescence-associated secretory phenotype …
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Npsd4: A New Player In Sumo-Dependent Dna Repair
… of DNA damage lesions can lead to mutations, oncogene activation, and genomic instability. Difficult-to-replicate-loci present barriers to DNA replication that, when not properly resolved, lead to replication fork stalling and collapse and genomic instability.</p> <p>DNA damage and replication …
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Modeling colorectal cancer initiation using human iPSC-derived intestinal organoids
… the early molecular events associated with three oncogenes employing bulk-RNA sequencing to examine genetic expression and pathway commonalities compared to existing primary literature in the field of CRC. METHODS: A CDX2-GFP reporter hiPSC line was transfected independently with three constructs …
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The Oncogenic Map Kinase Signaling Pathway Modulates Mhc-I Surface Expression In Melanoma
… the signaling components, particularly the proto-oncogene BRAF <sup>V600E </sup> that accounts for (40-50%) of these cases. Metastatic melanoma is one of the deadliest and most aggressive forms of cancer, with a 3-year survival rate of less than 15%. Immunotherapies that utilize cytotoxic T …
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The role of hCLCA2 and hCLCA4 in suppression of breast cancer progression
… such as DNA damage, ROS, telomere erosion, or oncogene activation. It is one of the primary tumor suppression mechanisms mediated by p53 and is often disabled in cancer cells. However, the downstream signaling pathway whereby p53 induces cellular senescence remains incomplete. We reported …
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A Semi-Supervised Predictive Model to Link Regulatory Regions to Their Target Genes
… an RNA binding protein that might be involved in oncogene activation and obtained interesting insights. </p><p>Together, these two models contribute to the understanding of enhancers and the key role they play in regulating tissue-specific expression patterns during development, as well as provide …
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An integrated approach to understanding the metabolic rewiring of cancer cells
… cells, including the influence of proliferation, oncogene activation, tumor suppressor loss, tissue of origin, metastatic potential, environmental cues, and many other factors. Further, metabolism comprises a large and complex network of interconnected reactions and transport processes that …
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A quantitative analysis of chemotherapy-induced reactive oxidative species using genetically encoded sensors and generators
… from genomic instability, inflammation and oncogene activation, and they become increasingly reliant on the cell antioxidant network to prevent this elevated oxidative stress from becoming toxic. Thus, chemotherapeutics that inhibit the antioxidant network and thereby elevating ROS are …
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Strategies for Oncogenesis by Avian Leukosis Viruses
<p>The mechanism of oncogenesis by avian leukosis viruses (ALVs) was examined. ALVs are slowly transforming RNA tumor viruses that do not transform cells in tissue culture and that cause neoplastic disease only after a latent period of 4-12 months. ALVs generally induce widely disseminating B cell …