Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"on-chip analysis"”.
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Solvent compatible microfluidic platforms for solid form screening of pharmaceutical parent compounds
A significant fraction of candidate pharmaceutical parent compounds (PCs) are rejected on account of poor physicochemical properties that affect their biopharmaceutical attributes such as bioavailability, toxicity, and stability. Hence, a major factor contributing to the high costs and turnaround …
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Optimization and application of normally closed microvalves in microfluidics
The ease of fabrication and integration of pneumatic microvalves has enabled extensive miniaturization of microfluidic devices that are capable of performing massively parallel operations. These valves in their typical open configuration, also known as normally open (NO) valves, require to be …
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Mesophase-based approaches for on-chip membrane protein crystallization and structure determination
… role in many processes in vivo. Malfunctions of membrane proteins have been shown to cause a variety of disease states, for example, cystic fibrosis, hereditary hearing loss, and hypothyroidism. Furthermore, membrane proteins are targets of over 60% of all drugs available on the market. …
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X-ray compatible microfluidic platforms for studying protein structure and function
… Act I, Scene 3. Knowledge of the three dimensional structure of a protein provides insight into its mechanism, as well as into potential sites for drug targeting. Often these insights provide functional information about an unknown protein, lead to a deeper understanding of how damaged proteins …