Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 310 for “"omics"”.
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Bayesian Integrative Analysis of Omics Data
… establishment in integrative analysis of radiogenomics and pathway driver detection applied in cancer applications. We initially present Radio-iBAG that utilizes Bayesian approaches in analyzing radiological imaging and multi-platform genomic data, which we establish a multi-scale Bayesian …
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Omics analysis in understanding disease mechanisms
The rapid evolution of omics technologies has revolutionized drug target discovery, transitioning from phenotypic and function-centric methodologies to more mechanistic and target-driven approaches. To maximise drug development success at earlier phases, understanding the role of targets in disease …
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Harnessing Cancer Omics to Inform Precision Oncology
… in an efficient way. Here, we conducted omics analysis on three different cancer studies and developed an LLM-based bioinformatics chatbot, DrBioRight, that can perform cancer omics data mining based on natural language. We identified ultraconserved elements (UCE) that can be enhancers of …
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High-dimensional Mediation Analysis of Multi-Omics Data
… have made mediation analysis of multi-omics data critical to gain groundbreaking insights into the biological mechanisms underlying the disease etiology. This dissertation aims to develop mediation analysis methods that utilize the enormous amount of multi-omics data in assessing …
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Omics-driven Insights into Congenital Disorders of Glycosylation
Contains fulltext : 327958.pdf (Publisher’s version ) (Open Access)
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Linear mixed model for multi-level omics data
… (TBLMM) for risk prediction with multi-level omics data. It can not only capture various types of effects from multi-omics data simultaneously, but also can capture complex within/between omics layer interactions through fused kernel functions. Through extensive simulations and the application …
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Elucidating the Multi-omics of Early-Onset Colorectal Cancer
… potential causes, we investigated the multi-omics of the EOCRC. Mutational signatures are the footprints of endogenous or exogenous exposomal exposures.</p> <p>In the first study, we focused on early-onset rectal cancer (EORC) where the epidemiologic changes are the most concerning. Using …
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Algorithms for discovering disease genes by integrating 'omics data
<p>Systems-level characterization of complex human diseases remains as one of the biggest challenges in the post-genomic era. Information useful for mechanistic understanding of diseases comes from different types of “-omic” data, including genomic sequences, gene expression, and molecular …
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Revealing the Mechanisms of Tumorigenesis Through Multi-Omics Analyses
… profiling of tumors through integrative multi-omics approaches. Large-scale cohort studies leveraging these tools have identified diverse cancer phenotypes, offering insights into the molecular diversity of malignancies. Yet, a critical challenge remains: the inability to systematically trace …
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Characterization of cancer and aging using multi-omics data
노화는 암을 포함한 많은 질병의 원인이 된다. 인간의 다양한 조직으로부터 추출한 DNA 메틸값을 이용해 실제 나이를 예측할 수 있다. 이는 DNA 메틸화가 노화의 지표가 될 수 있다는 의미이기도 하다. 하지만, 여러 조직의 정상과 종양 샘플의 많은 데이터 셋을 통합하여 노화 관련 DNA 메틸화 영역의 특징에 대해 밝힌 연구는 아직 많이 없는 실정이다. 본 연구에서는 16개 독립적인 연구의 DNA메틸화 및 유전자 발현 데이터를 통합하여 말초 혈액뿐만 아니라 유방, 자궁경부, 전립선, 뇌, 간, 대장 조직 등 다양한 조직의 대략 …
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Experimental design and analysis for high-parameter spatial omics
… enabled high-parameter molecular measurements (“omics”) to progress from bulk data, averaged across entire tissues or organisms, to single-cell measurements, which enable exploration of the vast diversity between individual cells, to a new frontier, spatial omics, which enables rich molecular …
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Computational methods for functional interpretation of diverse omics data
… in an explosive growth of various types of "omics" data, including genomic, transcriptomic, proteomic, and metagenomic data. Functional interpretation of these data is key to elucidating the potential role of different molecular levels (e.g., genome, transcriptome, proteome, metagenome) in …
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APPLICATION OF OMICS APPROACHES IN DRUG DISCOVERY AND BIOMARKER IDENTIFICATION
Recent advances in omics sciences have represented a revolution in many fields of biological research. Among these, lipidomics and metabolomics are gaining increasing interest due to their close connection with the organism’s phenotype. As the main analytical goal of omics approaches is to identify …
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Antibody-omics for biomarker discovery in vaccinology and infectious diseases
… Ultimately, our established multiplexed antibody-omics platform was expanded for deep biophysical characterization on a broad set of antigen-specific antibodies including isotype, subclass, FcR-binding, and glycosylation analysis. The second specific aim was to apply our robust antibody-omics …
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A Multi-omics Study of Human Mitochondrial Proteins During Neurogenesis
… published studies. Taken together, the multi-omics methods and computational strategies I have established in this study provided not only new insights of mitochondrial biology, but also a systems biology research focus to leverage the deluge of omics data. The findings from this study could …
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Understanding and stratifying brain health through blood-based omics data
Brain health across the lifespan is dynamic and influenced by a complex interplay of genetics and the environment. Age-related neurological diseases are a growing burden on healthcare systems and society. Individuals that do not have overt diagnoses of neurological diseases will still experience …
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