Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 103 for “"omic"”.
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Statistical methods for multi-omic data integration
… development of new ways to integrate multiple ’omic datasets in the context of precision medicine. This type of analyses have the potential to help researchers deepen their understanding of biological mechanisms underlying disease. However, integrative studies pose several challenges, due to the …
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Integration of Multi-Platform High-Dimensional Omic Data
… protein lysate arrays, etc. The high-dimensional omic data derived from different technological platforms have been extensively used to facilitate comprehensive understanding of disease mechanisms and to determine personalized health treatments. Although vital to the progress of clinical research, …
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Network-based approaches for multi-omic data integration
… systems, which produces different types of omic data such as genome, epigenome, transcriptome, translatome, proteome, metabolome and interactome. Biological systems are highly dynamic and complex mechanisms which involve not only the within-level functionality but also the between-level …
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Transcriptional and Multi-Omic Heterogeneity in Glioblastoma Stem Cells
… variation. In this project, I use multiple -omic data types from both bulk and single cell resolution to explore how multiple biological processes such as transcription and epigenetic regulation play into GSC heterogeneity in therapeutic vulnerabilities. With single cell/nuclei …
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Single cell -omic landscapes in normal and perturbed haematopoiesis
The use of single cell genomics technologies to generate atlases of healthy tissues has served both as a valuable comparator resource for perturbed datasets, and to permit the discovery of novel biological processes in the differentiation of stem cells into mature tissues. Large scale profiling of …
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ULTRA SCALABLE METHODS FOR DIFFERENTIAL TESTING OF SPATIAL-OMIC DATA
Spatial omic technologies are revolutionizing our ability to study tissue organization and function by preserving the spatial context of molecular measurements. Unlike traditional single-cell assays, which dissociate cells from their native environments, spatial methods retain information about …
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Integrating statistical and mechanistic modeling to analyze disease omic data
Item withdrawn by Laura Spradlin (lspradl2@illinois.edu) on 2013-10-30T20:45:53Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 WANG_YULIANG.docx: 2952821 bytes, checksum: 08c2e350ebf29e4a14805992d55ba80f (MD5) WANG_YULIANG.pdf: 3382980 bytes, …
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Differential Network Analysis based on Omic Data for Cancer Biomarker Discovery
… enables the generation of a large amount of omic data such as genomics, transcriptomics, proteomics, metabolomics, glycomics etc. Typically, differential expression analysis (e.g., student's t-test, ANOVA) is performed to identify biomolecules (e.g., genes, proteins, metabolites, glycans) …
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Causal Gene Prioritization Across Diverse Diseases Through Multi-Omic Data Integration
… now enable in-depth, high throughput multi-omic assessment (e.g. genomic sequencing, plasma proteomics) in large-scale patient and population studies. This thesis explores the application and integration of multi-omic data for the prioritization of effector genes underlying disease …
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Single-cell multi-omic data analysis with mathematical and statistical methods
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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Integrative and Scalable Pipeline for Multi-omic Characterization of Biological Tissues
… nuclei-based co-registration. We achieved multi-omic and multiplexed characterization of thick mouse brain tissues using our pipeline that enabled cell type analysis and ontogeny studies. Furthermore, effective preservation by EPIC-SHIELD allowed successful characterization of fresh frozen human …
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Multi-omic Analysis of Neurodegeneration in Alzheimer’s Disease and Related Dementias
… holistically. Our research characterizes a multi-omic data set comprising 2,820,565 cells from 491 samples of prefrontal cortex across the aforementioned conditions, with all samples subjected to scRNA-seq and 63 to scATAC-seq. Leveraging this data, we conduct a multi-omic analysis of Alzheimer’s …
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Bayesian Alignment Model for Analysis of LC-MS-based Omic Data
… (LC-MS) has been widely used in various omic studies for biomarker discovery. Appropriate LC-MS data preprocessing steps are needed to detect true differences between biological groups. Retention time alignment is one of the most important yet challenging preprocessing steps, in order to …
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Multi-omic Approaches to Investigate the Inflammatory Response in Activated Macrophage Cells
… cells during clearance (ATP). In-depth proteomic analyses<br/>identified significant metabolic reprogramming along with a promotion of<br/>macrophage differentiation and polarisation, and lipidomic analysis identified<br/>significant regulation of arachidonic acid and glycerophospholipid …
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Multi-omic analysis of contaminated sediments from Contrecoeur, QC on Planorbid snails
… survival, growth, reproductive output, metabolomic profile, and proteomic profile. A two-week in-situ exposure was performed on Helisoma trivolvis, and a 28-d laboratory exposure of Planorbella pilsbryi to the same sediments was completed. Snail tissue samples were collected for proteomic and …
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Multi-omic Studies of Neutrophils Reveal Programmed Deactivation Phenotypes After Inflammatory Stimulus
… strategies. A comprehensive time-course multi-omics study was conducted to evaluate the neutrophil response to a common human pathogen Staphylococcus aureus. This was undertaken using a model of healthy human neutrophils exposed to heat-killed, labelled S. aureus particles with the objective of …
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Low-Input Multi-Omic Studies of Brain Neuroscience Involved in Mental Diseases
… dose of psychedelic administration. The epigenomic and transcriptomic changes induced by 2,5-Dimethoxy-4-iodoamphetamine (DOI), a subtype of psychedelics, in mouse neuronal nuclei at various time points suggest that the long-lasting effects of the psychedelic are more closely related to …
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DISSECTING THE REGULATORY LOGIC OF CELL FATE REPROGRAMMING THROUGH A MULTI-OMIC APPROACH
… in microfluidics and temporal multi-omics to identify and resolve distinct sub-populations and their interactions. We perform secretome analysis and single-cell transcriptomics to show functional extrinsic pathways of protein communication between reprogramming sub-populations and the …
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