Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"oligonucleotide therapy"”.
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ENDOGENOUS ANTIVIRAL PROPERTIES OF RED BLOOD CELL-DERIVED EXTRACELLULAR VESICLES AND THEIR AUGMENTATION OF ANTIVIRAL OLIGONUCLEOTIDE THERAPY
… and their use as delivery vehicles for antisense oligonucleotides (ASOs). RBCEVs inhibited both pseudotyped and authentic SARS-CoV-2 infections in a dose-dependent manner by blocking viral entry. ASOs targeting conserved viral genes (helicase, 3CLPro, PLpro, RdRp, and TRS), delivered via RBCEVs, …
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Exploring SARM1 as a target to delay programmed axon degeneration
… Secondly, targeting SARM1 through antisense oligonucleotides shows that SARM1 protein levels can be decreased in vitro to a similar extent as Sarm1 hemizygosity using exogenously-applied nucleotides. This decrease in protein levels confers a delay in programmed axon degeneration in a range of …