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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 293 for “"oligomeric"”.
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Total Synthesis of Oligomeric Cyclotryptamine Alkaloids
… diazene synthesis using increasingly complex oligomeric hydrazide nucleophiles and bifunctional cyclotryptamines bearing a C3a leaving group and a pendant C7 pronucleophile. The utility of our method is demonstrated by the first total synthesis of heptamer (+)-caledonine and hexamer …
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Characterization of Tau Oligomeric Strains: Implications for Disease Phenotypes
… tangles, our lab and others found that small, oligomeric aggregates are likely the most toxic species. I found that toxic tau oligomers are elevated in progressive supranuclear palsy, traumatic brain injury and synucleinopathy models and reversal of toxicity can be achieved with treatment of a …
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Small Molecules Targeting and Modulating Toxic Tau Oligomeric Strains
… exhibits conformational differences, termed tau oligomeric strains. Due to the dynamic nature of these strains, little is currently known about the mechanisms underlying their formation and characteristics. Therefore, modulating their aggregation states and conformations through the use of small …
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Investigating self-assembly of linked oligomeric PPV-based materials
… the effect of synthetic structure of the oligomeric PPV-based materials was investigated to understand the effect of conjugation length, role of hydrogen bonding side chains, and influence of regioregularity on controlling chromophore folding. By studying alkoxy-linked and alkyl-linked …
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Strategies for the Controlled Synthesis of Oligomeric Natural Products
1 - Total Syntheses of Helicterin B, Helisorin, and Helisterculin A - The total synthesis of three members of the helicterin family of natural products, helicterin B, helisorin and helisterculin A, was completed from a common, non-biomimetic intermediate. This work featured the development of a …
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Atomistic simulations of octacyclopentyl polyhedral oligomeric silsesquioxane polyethylene nanocomposites
… fillers such as carbon nanotubes, polyhedral oligomeric silsesquioxane (POSS), and layered silicates have already been successfully used to improve the thermal and mechanical properties of polymers. On this length scale, details describing particle organization, interaction between particles, …
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Cartilage oligomeric matrix protein in der Pathogenese der Arthrosis deformans
… Thrombospondin-Gen-Familie, ist das Cartilage oligomeric matrix protein (COMP) hauptsächlich in der extrazellulären Matrix zu finden. Eine häufige Bindung an Knorpel konnte bereits nachgewiesen werten. Weiter ist COMP in Synovialflüssigkeiten und dem Bandhalteapparat nachweisbar. Es konnten …
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Studies towards Selective Synthesis of Resveratrol-based Oligomeric Natural Products
… efforts in the field of resveratrol-based oligomeric natural product synthesis. Both biosynthetic approaches and stepwise synthetic approaches are discussed to present the current level of understanding regarding the controlled synthesis of these molecules in order to place the studies …
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Beta-Amyloid oligomeric and monomeric states: implications for Alzheimer's Disease
Alzheimer's Disease (AD) is by far the most common cause of dementia affecting more than 35 million people worldwide. Despite considerable research, there is still no cure for this neurodegenerative disease and available treatments are only symptomatic. In the controversial literature about AD, a …
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Thermomechanical properties of polyhedral oligomeric silsequioxane- poly(methyl methacrylate) nanocomposites
… methacrylate)s (PMMA) containing polyhedral oligomeric silsesquioxane (POSS) nanoparticles (d [approx.] 1.5 nm) were subjected to heological, mechanical, and morphological tests to determine the effects that POSS has on the melt-state and solid-state properties of this commercially important …
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Synthesis and Characterization of Polyhedral Oligomeric Silsesquioxane (POSS) Based Amphiphiles
Polyhedral oligomeric silsesquioxanes (POSS) have attracted substantial academic interest for many years as hybrid materials and nanofillers for controlling thermal and mechanical properties, and providing thermal and chemical resistance while retaining ease of processing. A natural extension of …
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Synthesis and Characterization of Polyhedral Oligomeric Silsesquioxane (POSS) Based Amphiphiles
Polyhedral oligomeric silsesquioxanes (POSS) have attracted substantial academic interest for many years as hybrid materials and nanofillers for controlling thermal and mechanical properties, and for providing thermal and chemical resistance while retaining ease of processing. A natural extension …
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Novel oligomeric and polymeric materials based upon the dibenzotetraaza[14]annulenes.
The class of compounds known as the dibenzotetraaza[14]annulenes have been of particular interest over the past 25 years, with the initial impetus for research being the relationship they hold with the naturally occuring porphyrins.The main aim of the work undertaken was to establish the potential …
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The adsorptive properties of oligomeric, non-ionic surfactants from aqueous solution
… solution onto mineral oxide surfaces. The oligomeric distributions of the surfactants were characterised using the HPLC technique. Two gradients were used: a normal phase gradient was used to study the surfactants from non-aqueous solution; an unusual gradient, which could not be …
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Novel type-II nanocrystal quantum dots and versatile oligomeric phosphine ligands
… of novel type-II quantum dots and versatile oligomeric phosphine ligands. Type-II band engineered quantum dots (CdTe/CdSe(core/shell) and CdSe/ZnTe(core/shell) heterostructures) are synthesized by chemical means. The optical properties of these type-II quantum dots are studied in parallel …
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Exploring the oligomeric state of TLR4 and downstream regulators RIPK1 and RIPK3
Toll-like receptors (TLRs) are a group of pattern recognition receptors involved in innate immunity. Their extracellular domain is made of leucine-rich repeats that recognise ligands, leading to the dimerisation of their intracellular Toll/interleukin 1 receptor (TIR) domain, which builds a …
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The design and structural characterization of oligomeric beta beta alpha mini-proteins
Oligomeric mini-proteins, short peptides with protein-like features, constitute valuable minimal models for the study of oligomeric proteins. Oligomerization is a common feature of cellular proteins that may confer structural and functional advantages. Oligomerization is proposed to have arisen by …
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