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Showing 1 to 20 of 249 for “"oligomer"”.
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Solid Phase Synthesis of M-Phenylene Ethynylene Oligomer Heterosequences
The synthesis of m-phenylene ethynylene (mPE) oligomers is currently a tedious process. To address this, two methods for the solid-phase synthesis of mPE oligomers (including heterosequences) have been developed. The first strategy employs a silyl-acetylene linker attached to ArgoGel(TM) solid …
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Multicoil-HMM : improved prediction of coiled-coil oligomer state from sequence
… offers improved prediction of coiled-coil oligomerization state. The algorithm combines the pairwise correlations of the Multicoil method with the flexibility of HMM methods. The resulting method incorporates predictors deemed important by a multinomial logistic regression to distinguish …
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The stereoselective synthesis of a novel aromatic peptide nucleic acid (APNA) oligomer
… block for the synthesis of a novel class of oligomers, the aromatic peptide nucleic acids (APNA). The APNA tetramer 70 was prepared from the amino acid monomer (S)-50 using classical peptide synthesis. Chemical shift differences between the $\sp1$H NMR of monomer (S)-57 and tetramer 70 were …
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Oligomer dynamics for drug discovery against α-synuclein aggregation in Parkinson's disease
… α-synuclein aggregation may be linked to soluble oligomeric species that serve as precursors to mature fibrils. These intermediate species are transient, amorphous and highly heterogenous in solution, which has precluded the study of their population dynamics in the context of drug discovery and …
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Investigating protein folding by the de novo design of an α-helix oligomer
… studies demonstrated formation of a high order oligomer with increased protein concentration. These results and analysis prove that the knob-socket model is a predictive model for all α-helical protein packing. More importantly, the knob-socket model introduces a new protein design method that …
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Discrete polyene oligomer synthesis and related polymer characterization : (Appendix I: Reduced tungsten dimeric compounds)
… complexes ... were used to synthesize polyene oligomeric compounds with up to 15 conjugated double bonds by reaction with aldehyde compounds in a Wittig-like fashion. The optical properties of highly nr-conjugated systems are investigated due to potential application in photooptical materials. …
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Investigating the effects of extracellular biomolecules on Aß1-42 oligomer uptake and trafficking by microglia cells
… Previous studies have pointed towards sol- uble oligomers (SO) as opposed to mature amyloid fibrils as the predominant toxic species. This thesis explores the internalisation of SO by a microglia cell line (EOC 13.31) and provides new in- sights into the modulation of this process by naturally …
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Molecular and Pharmacological Studies of Alpha1-AR Subtypes and their Signaling Pathways
… respectively) subtype expression using antisense oligomer approaches. Using the nucleotide sequence of the (Xib-AR and ccid-AR subtypes, antisense oligomers were designed and tested for their effectiveness at inhibiting cti-AR subtype expression in vitro. For these studies two cell culture models …
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Synthesis of Nanostructured Organic and Inorganic Materials by Self-Assembly
… of mesophase structure in the presence of the oligomer n&d1;=6 indicates a transformation of hexagonal to lamellar structure at low oligomer contents. For a surfactant with longer hydrophile, this transformation takes place at higher oligomer concentrations. A similar phase transformation is …
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Helical Pitch, Hydrophobic Binding, Chiral Templation, and Supramolecular Chelation of M-Phenylene Ethynylene Foldamers
… different m-phenylene ethynylene (m PE) folding oligomers or foldamers were designed, synthesized, and studied. These chain molecules have been shown to adopt a helical conformation under appropriate conditions in solution. A series of double TEMPO spin labeled oligomers were studied by electron …
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Synthesis and Characterization of Hydrophobic-Hydrophilic Segmented and Multiblock Copolymers for Proton Exchange Membrane and Reverse Osmosis Applications
… that synthesizing blocky copolymers using a one oligomer, two monomer segmented copolymerization afforded copolymers with similar properties to those which used a previous approach of coupling two preformed oligomers. A 4,4′-biphenol based hydrophilic block of disulfonated poly(arylene ether …
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Folding-Promoted Reactivity and Tunable Structure of Pyridine-Containing M-Phenylene Ethynylene Helical Cavitands
… to stabilize the folded conformation of a PE oligomer. Subsequent studies focus on the incorporation of pyridine rings into the chain sequence. The pKa value of the pyridine nitrogen can be modulated either by changing the substituents on the pyridine ring, or in some cases, through …
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Small Molecules as Amyloid Inhibitors: Molecular Dynamic Simulations with Human Islet Amyloid Polypeptide (IAPP)
… with numerous diseases. IAPP forms toxic oligomers and amyloid fibrils that reduce pancreatic β-cell mass and exacerbate the T2D disease state. Toxic oligomer formation is attributed, in part, to the formation of inter-peptide β-strands comprised of residues 23-27 (FGAIL). Flavonoids, a …
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Analysis of Alcohol and Alkylphenol Polyethers via Packed Column Supercritical Fluid Chromatography
… products and detergents. They are formed as an oligomeric series with a varying distribution, which determines their commercial application. The goal of the research performed was the development of sample characterization methods for non-ionic surfactants utilizing supercritical fluid …
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On transient assemblies in amyloid formation: mechanistic insights and therapeutic strategies
… diagnoses of these conditions, pre-fibrllar oligomers are increasingly recognised as the major toxic agents. However, these assemblies pose significant experimental difficulties due to their transient nature, structural heterogeneity, and low concentrations in the aggregation reactions, which …
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Part I: Peptide Dendrimers From Natural Amino Acids. Part II: Nonfullerene Nanotubes From Bridged Dendritic Metalloporphyrin Complexes
… was exhibited in the MALDI mass spectra for each oligomer. The cored out structure 53 was soluble in common organic solvents enabling their partial size separation by a preparative SEC. The SEC results in NMP suggested that the cross-linked oligomer 51 had an Mw of 83,790 Da (DP = 15), and the …
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Synthesis, characterization and properties of epoxide containing block and alternating copolymers
… from O.75K-40K. Monohydroxy functionalized PEO oligomers have been synthesized with potassium tert-butoxide as an initiator in tetrahydrofuran, and in the bulk. The PEO oligomers were reacted with 4-(chloromethyl) benzoyl chloride to yield a 4-(chloromethyl) benzoate functionalized PEO oligomer …
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Phenylacetylene oligomers as synthetic information molecules
… forming properties, and attempts at templated oligomerisation reactions. The new synthetic information molecule is based on the phenylacetylene oligomer framework developed by Moore and co-workers. Recognition was achieved via a base-pair that is made from a single point high affinity H-bond, …
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