Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"oligodendrocyte progenitor cell"”.
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Changes in the Oligodendrocyte Progenitor Cell Nuclear Lamina During Ageing
Following the loss of oligodendrocytes in demyelinating diseases such as multiple sclerosis (MS), new oligodendrocytes can be generated from the oligodendrocyte progenitor cell (OPC), a multipotent progenitor cell of the central nervous system. However, the efficiency of this regenerative process …
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The brain microenvironment and its role in oligodendrocyte progenitor cell ageing
… in molecular interplay between the brain extracellular matrix (ECM), oligodendrocyte progenitor cells (OPCs) and astrocytes. During ageing the resident brain progenitors undergo cellular arrest causing a diminished regenerative response. Increasing research evidence supports the notion that the …
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An improved method for generating oligodendrocyte progenitor cells from murine induced pluripotent stem cells
Cell based therapies aiming to restore myelin in the central nervous system offer great hope for treatment of numerous conditions, ranging from multiple sclerosis and the leukodystrophies, to traumatic CNS injury. The oligodendrocyte progenitor cell (OPC) gives rise to functional oligodendrocytes …
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Investigating the role of cellular communication network factor 3 (CCN3) in central nervous system myelination and remyelination
… immune-mediated destruction of myelin-producing oligodendrocytes. While there is a plethora of disease-modifying therapies to reduce relapses, there are currently no available treatments to boost oligodendrocyte and myelin regeneration. Therefore, uncovering the mechanisms that regulate …
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Developing EasySci, a High-Throughput and Low-Cost Single-Cell Genomic Technique, to Study Aging and Alzheimer's Disease in Human and Mouse Brain
<p>Previous single-cell methods are limited by their relatively low throughput and high costs. This prevents most laboratories from performing large-scale cell profiling, complicating the understanding of rare cell type contributions to aging and disease. Moreover, these methods often focus on the …
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Imaging Myelin Basic Protein expression in a model of remyelination by Magnetic Resonance Imaging using an Organic Anion Transporter Protein gene reporter system.
… by 1) pharmacologically targeting endogenous oligodendrocyte progenitor cells (OPCs) responsible for remyelination or 2) transplantation of myelinogenic cells (including OPCs). The first approach is appropriate for diseases with no defect in the myelinating cells, such as multiple sclerosis …
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Investigating neuroectodermal transdifferentiation: How do CNS progenitors form Schwann cells?
… central nervous system (CNS) are myelinated by oligodendrocytes. However, in response to demyelination, Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), can contribute to CNS remyelination. Although CNS-resident SCs were previously thought to have migrated into …