Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"oligodendrocyte differentiation"”.
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Autotaxin: A Regulator of Oligodendrocyte Differentiation
<p>In order for oligodendrocyte progenitor cells (OPCs) to differentiate into fully mature, myelinating oligodendrocytes, they must be specified at the correct times and undergo coordinated changes in both gene expression and morphology. As oligodendrocytes differentiate, they transition from a …
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Regulation of Oligodendrocyte differentiation through Neuroligin-Neurexin signalling
… work presented here investigates NL’s role in oligodendrocytes (OLs), a subtype of glial cells responsible for the myelination in the central nervous system. This was accomplished by first determining NL’s presence in this cell type in hippocampal dissociated cultures by immunocytochemistry and …
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… spinal cord neural stem/progenitor cells (NPCs), oligodendrocyte precursor cells (OPCs), astrocytes and neurons. Here, for the first time, we demonstrate that BMP4 promotes cleaved caspase-3 expression in cultured neurons and oligodendrocytes and that acute BMP inhibition attenuates apoptosis and …
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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… to determine how the myelin sheath or the oligodendrocytes that synthesize the sheath are damaged. Thus, we hypothesized that the administration of ART contributed in part to the myelin loss in the CNS of HIV-positive patients. Previously, we have reported that the protease inhibitor class …
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Neural differentiation of pluripotent stem cells and applications to micropatterned agarose hydrogel for nerve guidance
… (CNS) disorders are attributable to damaged oligodendrocytes, the cells that form the myelin sheath of axons. An effective source of human oligodendrocytes is crucial, making pluripotent stem cells, such as embryonic stem (ES) cells, an attractive source for nerve tissue repair and …
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Developmental myelination and myelin plasticity during spatial working memory task acquisition
… neuronal impulses. Myelin sheaths are created by oligodendrocytes, which stem from oligodendrocyte precursor cells. During development neurons become myelinated, and this process can be modulated by environmental factors, ageing and various neurological disorders. The notion that myelin plays a …
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Axon-glia interactions during central nervous system myelination
… function of neuronal circuits. However, axon-oligodendrocyte interactions regulating the onset of myelin formation remain unclear. I sought to determine how reticulospinal axons control myelination, as they are the first myelinated in the zebrafish spinal cord. I genetically manipulated …
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Calcium/Calmodulin-Dependent Protein Kinase II Beta (CaMKIIβ): A Regulator of Oligodendrocyte Maturation and Myelination
<p>Oligodendrocytes are cells located in the central nervous system (CNS) that are responsible for the production of the lipid rich membrane, myelin. Myelin and the process of making and wrapping myelin around an axon (also known as myelination) are critical for normal development since they ensure …
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Novel mechanism in astrocyte gene regulation and function
… which can be further extrapolated to astrocyte differentiation and glial tumor invasion. First, we cloned and analyzed human NFI-X3, a novel splice variant of the nfix gene, which contains a unique transcriptional activation (TA) domain completely conserved in primates. In contrast to previously …
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OPPOSING ROLES OF THE μ-OPIOID AND NOCICEPTIN/ORPHANIN FQ RECEPTORS IN OLIGODENDROCYTE DEVELOPMENT AND MYELINATION
… conduction, this membrane and the myelin-making oligodendrocytes (OLGs) are now recognized as regulators of plasticity and remodeling in the central nervous system (CNS). Thus, OLG maturation and myelination are highly vulnerable processes along CNS development. We previously showed that rat …