Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"oligodendrocyte development"”.
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Role of miRNAs in Oligodendrocyte Development
MicroRNAs (miRNAs) sind entscheidend für die Regulation von unterschiedlichen Prozessen in der Zellbiologie. Die Funktion von miRNAs im Zentralen Nervensystem (ZNS) und besonders in Gliazellen ist jedoch weitgehend unbekannt. Im ZNS werden Oligodendrozyten für die Myelinisierung der Axone benötigt. …
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The role of thromboxane A(2) receptor signaling in oligodendrocyte development.
… role of thromboxane A(2) receptor signaling in oligodendrocyte development.
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Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System
Oligodendrocytes (OLs) produce myelin sheaths that electrically insulate axons and promote rapid propagation of action potentials in the CNS. The onset and timing of CNS myelination and remyelination requires precise coordination between epigenetic programming and transcriptional regulation. In …
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OPPOSING ROLES OF THE μ-OPIOID AND NOCICEPTIN/ORPHANIN FQ RECEPTORS IN OLIGODENDROCYTE DEVELOPMENT AND MYELINATION
… conduction, this membrane and the myelin-making oligodendrocytes (OLGs) are now recognized as regulators of plasticity and remodeling in the central nervous system (CNS). Thus, OLG maturation and myelination are highly vulnerable processes along CNS development. We previously showed that rat …
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OPIOID ADDICTION AND PREGNANCY: POTENTIAL EFFECTS OF SUBSTITUTION THERAPIES ON DEVELOPMENTAL MYELINATION
… the role of the endogenous opioid system in CNS development remains poorly understood. Identification of opioid functions during brain maturation is particularly crucial in light of the increasing trend in opioid abuse and the use of opioid drugs during pregnancy. New substitution therapies in …
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Autotaxin: A Regulator of Oligodendrocyte Differentiation
<p>In order for oligodendrocyte progenitor cells (OPCs) to differentiate into fully mature, myelinating oligodendrocytes, they must be specified at the correct times and undergo coordinated changes in both gene expression and morphology. As oligodendrocytes differentiate, they transition from a …
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Endogenous Neurosteroid Hormone Production and Early Oligodendricyte Development
… CNS-specific processes known to regulate neural development and pathology. Multiple sclerosis (MS), a debilitating neurodegenerative disorder classified by rampant demyelination, exemplifies the neuroendocrine crosstalk facilitated by CNS-resident steroids. Local steroid production from …
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Focal adhesion kinase, a major regulator of oligodendrocyte morphological maturation and myelination
… of the myelin sheath is a crucial step during development because it enables fast and efficient propagation of signals within the limited space of the mammalian central nervous system. During the process of myelination, oligodendrocytes actively interact with the extracellular matrix (ECM). …
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Axon-glia interactions during central nervous system myelination
… function of neuronal circuits. However, axon-oligodendrocyte interactions regulating the onset of myelin formation remain unclear. I sought to determine how reticulospinal axons control myelination, as they are the first myelinated in the zebrafish spinal cord. I genetically manipulated …
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Calcium/Calmodulin-Dependent Protein Kinase II Beta (CaMKIIβ): A Regulator of Oligodendrocyte Maturation and Myelination
<p>Oligodendrocytes are cells located in the central nervous system (CNS) that are responsible for the production of the lipid rich membrane, myelin. Myelin and the process of making and wrapping myelin around an axon (also known as myelination) are critical for normal development since they ensure …
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Stressed Astrocytes: Insights on the Pathology of Alexander Disease
… of astrocytes, and easily detectable staining of oligodendrocytes. Finally, I examined the localization of the cell surface glycoprotein CD44, along with several related proteins, including its ligand hyaluronan. I found CD44 protein expression greatly increased in the white matter, cortex and …
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Regulation of Oligodendrogenesis in a Rat Contusive Spinal Cord Injury
"Loss of oligodendrocytes (OLs) and ensuing demyelination significantly hamper functional recovery following traumatic spinal cord injury (SCI). Although proliferating glial progenitor cells (GPCs) are present in the lesioned spinal cord, spontaneous remyelination is extremely limited. The failure …