Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 130 for “"oligodendrocyte"”.
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Autotaxin: A Regulator of Oligodendrocyte Differentiation
<p>In order for oligodendrocyte progenitor cells (OPCs) to differentiate into fully mature, myelinating oligodendrocytes, they must be specified at the correct times and undergo coordinated changes in both gene expression and morphology. As oligodendrocytes differentiate, they transition from a …
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Role of miRNAs in Oligodendrocyte Development
MicroRNAs (miRNAs) sind entscheidend für die Regulation von unterschiedlichen Prozessen in der Zellbiologie. Die Funktion von miRNAs im Zentralen Nervensystem (ZNS) und besonders in Gliazellen ist jedoch weitgehend unbekannt. Im ZNS werden Oligodendrozyten für die Myelinisierung der Axone benötigt. …
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Oligodendrocyte precursor cell states and their regulation
Oligodendrocyte precursor cells (OPCs) differentiate into myelinating oligodendrocytes throughout life, allowing the formation of myelin during early development, but also following learning or demyelinating injuries. A number of factors are thought to regulate OPC proliferation and …
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Regulation of Oligodendrocyte differentiation through Neuroligin-Neurexin signalling
… work presented here investigates NL’s role in oligodendrocytes (OLs), a subtype of glial cells responsible for the myelination in the central nervous system. This was accomplished by first determining NL’s presence in this cell type in hippocampal dissociated cultures by immunocytochemistry and …
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Conductive PEDOT:PSS fibres for modelling and assessing oligodendrocyte ensheathment
Oligodendrocytes are recognised for their capacity to ensheath neuronal axons with tightly packed, multi-layered cell membranes, forming the myelin sheath. This myelin sheath plays a pivotal role as an insulating layer surrounding neuronal axons. It effectively segregates the conductive …
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Changes in the Oligodendrocyte Progenitor Cell Nuclear Lamina During Ageing
Following the loss of oligodendrocytes in demyelinating diseases such as multiple sclerosis (MS), new oligodendrocytes can be generated from the oligodendrocyte progenitor cell (OPC), a multipotent progenitor cell of the central nervous system. However, the efficiency of this regenerative process …
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The role of thromboxane A(2) receptor signaling in oligodendrocyte development.
… role of thromboxane A(2) receptor signaling in oligodendrocyte development.
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Investigating interplay between human regulatory T cells and oligodendrocyte lineage cells
… or demyelination, can be initially restored by oligodendrocyte progenitor cells (OPCs) that migrate to, and proliferate in the site of injury, differentiate into mature oligodendrocytes (OLs) and generate new myelin sheaths, a process termed remyelination. The signals that influence this process …
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Stereological Analysis of Oligodendrocyte Progenitor Cells In the Adult Mouse Brain
The main goal of this study was to further explore the hypothesis that experience-dependent neural network activity and neurotransmission can modulate adult OPC proliferation and differentiation. More specifically, we used stereology to establish whether extensive reference memory training and …
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Diet and respiratory viral infection alter oligodendrocyte homeostasis and myelination processes
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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The brain microenvironment and its role in oligodendrocyte progenitor cell ageing
… between the brain extracellular matrix (ECM), oligodendrocyte progenitor cells (OPCs) and astrocytes. During ageing the resident brain progenitors undergo cellular arrest causing a diminished regenerative response. Increasing research evidence supports the notion that the ageing brain ECM not …
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Functional heterogeneity of oligodendrocyte progenitor cells in the central nervous system
Oligodendrocytes are the myelinating cells of the central nervous system (CNS), whose function is to optimise neuronal transmission and preserving axonal integrity. Oligodendrocytes are derived from a stem cell population, called oligodendrocyte progenitor cells (OPCs). Oligodendrocyte lineage …
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