Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"olfactory system"”.
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Axon Guidance In The Mouse Olfactory System
Within the mouse olfactory system, 1200 different types of olfactory sensory neurons use molecular cues to appropriately target stereotyped locations within the olfactory bulb. Recent studies reveal that some of these molecular cues are regulated by olfactory receptor mediated neuronal activity. …
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Encoding and Processing of Accessory Olfactory System Odorants
The accessory olfactory system is a mouse olfactory subsystem dedicated to the processing of nonvolatile odors originating from the excretions of other animals. Accessory olfactory system activity drives behaviors critical for mouse survival such as mating, aggression, and predator avoidance. …
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Feedforward and Feedback Signals in the Olfactory System
… conglomeration of myriad activities in neural systems often results in prominent oscillations. The primary goal of the research presented in this thesis was to study effects of sensory stimulus on the olfactory system of rats, focusing on the olfactory bulb (OB) and the anterior piriform cortex …
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Magnetic Resonance Imaging (Mri) Studies of the Rat Olfactory System
… applied to study effects of neonatal, unilateral olfactory denervation on postnatal olfactory bulb growth. The in vivo imaging data were used to quantify the reduction in laminar volumes of the denervated bulb, compared to contralateral control bulb, unoperated normal rat bulbs and with …
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Neural Dynamics, Adaptive Computations, and Sensory Invariance in an Olfactory System
… and time in the early processing stages of olfactory systems. What features of these spatiotemporal neural response patterns encode stimulus-specific information (i.e. ‘neural code’), and how they are translated to generate behavioral output are fundamental questions in systems neuroscience. …
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Representations and Transformations of Odor Information in the Mouse Olfactory System
… of critical importance for survival. The mouse olfactory system mediates both learned and innate odor-driven behaviors, including activities as diverse as the localization of food sources, the avoidance of predators, and the selection of mates. How a chemical stimulus in the environment …
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Bilateral processing of thermoreception in the olfactory system of larval Xenopus laevis
… neue und adäquate Qualität des olfaktorischen Systems in Wirbeltieren darstellt.
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The glial cell line-derived neurotrophic factor family in the olfactory system and brain
… types, including neurons in the central nervous system. The family consists of four ligands [GDNF, neurturin (NTN), artemin and persephin] which bind to four co-receptors (GFRα1-4) and recruit the tyrosine kinase receptor RET into the signaling complex. In vivo, the ligands bind to the …
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Olfactory Receptor Antagonism in the OR-I7 Aldehyde Receptor and the Mammalian Olfactory System
… is initiated when an odorant binds and activates olfactory receptors (ORs) within the nose. Chapter 1 studies the structural requirements for activation of the OR-I7 aldehyde receptor. Octanal is an agonist of the OR-I7 receptor. 4-Ethylcyclohexylacetaldehyde (<strong>1.1)</strong>, with a …
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The Roles of Wnt5 and the Drl Receptor in the Development of the Drosophila Olfactory System
During the development of the Drosophila olfactory system, olfactory receptor neurons expressing the same odorant receptors converge their axons precisely onto a specific set of projection neuron dendrites, forming glomeruli in stereotypic positions of the antennal lobe. Although many studies have …
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The transcription factors Pax-6 and X-dll3 influence visual and olfactory system development in Xenopus laevis
… ectopic eye formation, and a reduction of the olfactory placode. Both Xenopus A and Xenopus B can elicit the reduction of both lens and olfactory placodes, and the expansion of retinal tissue, while only Xenopus A can elicit ectopic eye formation and ectopic lens crystallin expression. These …
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The Ultrastructure of the Olfactory System in Two Species of Short-Tailed Shrews, <i>Blarina brevicauda</i> and <i>Blarina carolinensis</i>
<p>Several studies of the fine structure of the olfactory system of rodents have been conducted, but very little research has been done on members of the Insectivora. The olfactory systems of the northern short-tailed shrew, <em>Blarina brevicauda</em>, and the southern short-tailed shrew, …
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The Role of Drosophila Odorant Receptors in Odor Coding
… genetic model organism, and a promising model system in olfaction. At the onset of my thesis research, the expression patterns of fly's 62 odorant receptors (ORs) were largely unknown. I set out to understand the rules of connectivity of olfactory sensory neurons and the resulting properties of …
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Cracking the Odor Code: Molecular and Cellular Deconstruction of the Olfactory Circuit of Drosophila Larvae
<p>The Drosophila larva offers a powerful model system to investigate the general principles by which the olfactory system processes behaviorally relevant sensory stimuli. The numerically reduced larval olfactory system relieves the formidable molecular and cellular complexity found in other …
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The role of complex gangliosides in glial cell biology
… that are enriched in the nervous system. They are located in the outer leaflet of the plasma membrane within lipid rafts and are thought to be involved in numerous cellular events, including proliferation, differentiation, migration and neurite outgrowth. Gangliosides have also …
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Mechanisms Underlying Learning Mediated Plasticity in the Adult Mammalian Olfactory Bulb
The olfactory system is rapidly modified by learning, starting at the first informational relay station. The olfactory bulb retains high levels of plasticity throughout adulthood and undergoes lasting structural changes following classic learning paradigms. Recent studies are starting to elucidate …
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Non-Canonical Odor Coding Ensures Robust Mosquito Attraction to Humans
… bite humans. It remains unknown how the mosquito olfactory system is seemingly infallible in its ability to detect humans for taking a blood meal. In the well-studied olfactory systems of Drosophila melanogaster and Mus musculus, individual olfactory sensory neurons express a single type of …
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Interactions of Thyroid Hormones, Nerve Growth Factor and Its Receptors in Development and Plasticity of the Rat Olfactory Bulb
Hypothyroidism decreased levels of olfactory bulb NGF, while up-regulating NGF receptors, p75$\sp{\rm NTR}$ and trkA in the glomerular region. We propose that decreased bulbar NGF results in decreased trophic support for specific NGF responsive cells, leading to compensatory up-regulation of NGF …
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THE ROLE OF DMRT GENES DURING NEUROGENESIS IN THE ZEBRAFISH FOREBRAIN
… for the development of the telencephalon, olfactory system and the neuro-endocrine system. In parallel, I was able to knock-out dmrt3 in zebrafish by introducing frameshift mutations of variable length into the dmrt3 locus using zinc finger nucleases. These dmrt3 mutants provide an …
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