Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"olfactory sensory neurons"”.
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Axon Development and Synapse Formation in Olfactory Sensory Neurons
The olfactory epithelium (OE) possesses the rare capacity among neuronal tissues to regenerate throughout life. As a result, progenitor cells continuously proliferate and differentiate into olfactory sensory neurons (OSNs) that project their axons to the olfactory bulb (OB) where they establish …
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Axon Guidance In The Mouse Olfactory System
Within the mouse olfactory system, 1200 different types of olfactory sensory neurons use molecular cues to appropriately target stereotyped locations within the olfactory bulb. Recent studies reveal that some of these molecular cues are regulated by olfactory receptor mediated neuronal activity. …
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Non-Canonical Odor Coding Ensures Robust Mosquito Attraction to Humans
… disease vector. Mosquitoes rely heavily on chemosensory cues, including carbon dioxide (CO2) emitted from breath and human body odor, which is a mixture of more than 200 different individual odorants. Although the exact odor profile of people varies considerably, Aedes aegypti are incredibly …
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Cracking the Odor Code: Molecular and Cellular Deconstruction of the Olfactory Circuit of Drosophila Larvae
… investigate the general principles by which the olfactory system processes behaviorally relevant sensory stimuli. The numerically reduced larval olfactory system relieves the formidable molecular and cellular complexity found in other organisms. This thesis presents a study in four parts that …
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Transgenic Tools in Ants and the Representation of Alarm Pheromones in the Ant Antennial Lobe
… the wellcharacterized vinegar fly, the primary olfactory processing centers (antennal lobes) contain an order of magnitude more functional units compared to the vinegar fly, presumably to facilitate detecting and discriminating between vast numbers of pheromones. The discovery of additional …
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Cloning, stem cells and epigenetic reprogramming after nuclear transfer
… embryos by NT from both cortical and mature olfactory sensory neurons to address question of nuclear equivalence in the brain and to investigate whether generation of synaptic diversity or odorant receptor choice, are mediated by genetic as well as epigenetic events.
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Olfactory Receptor Antagonism in the OR-I7 Aldehyde Receptor and the Mammalian Olfactory System
… is initiated when an odorant binds and activates olfactory receptors (ORs) within the nose. Chapter 1 studies the structural requirements for activation of the OR-I7 aldehyde receptor. Octanal is an agonist of the OR-I7 receptor. 4-Ethylcyclohexylacetaldehyde (<strong>1.1)</strong>, with a …
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Mechanisms of Volatile Odorant Detection and Corresponding Behavioral Effects in Drosophila
… stimuli, which are mediated by primary sensory neurons of different modalities including sight, hearing, touch, taste, and smell. Olfaction serves a major role in conveying important information concerning a variety of behavioral determinants such as food sources, danger, and cues from …
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Modulation and Ligand Selectivity of Mammalian Odorant Receptors
… 1000 in mouse. Central to the question of how olfactory stimuli are represented at the peripheral level is defining the ligand selectivity and activity regulation of ORs.</p><p>Processing of chemosensory signals in the brain is dynamically regulated in part by an animal’s physiological state. …
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Functional characterization of olfactory receptors and molecular species identification of vector mosquitoes.
… can detect environmental cues by utilizing sensory appendages such as antennae, maxillary palps, and labella. These structures are covered in small hair-like sensilla. Within sensilla reside dendritic extensions of olfactory sensory neurons that are embedded with ligand gated olfactory …
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Neural Dynamics, Adaptive Computations, and Sensory Invariance in an Olfactory System
<p>Sensory stimuli evoke spiking activities that are patterned across neurons and time in the early processing stages of olfactory systems. What features of these spatiotemporal neural response patterns encode stimulus-specific information (i.e. ‘neural code’), and how they are translated to …
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Insect Host Seeking: Investigations into the Molecular Mechanisms of Chemosensation
<p>Among other functions, chemosensory systems play a crucial role in the host-seeking behaviors of insects that allow them to find their preferred food sources. Quite often, however, these host-seeking behaviors have a negative impact on either human health or livelihood. The following details …
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The Role of Drosophila Odorant Receptors in Odor Coding
… out to understand the rules of connectivity of olfactory sensory neurons and the resulting properties of olfactory circuit. Consequently, we assembled maps of the olfactory neuron projections in the fly brain and characterized the contribution of several ORs to olfactory-guided behavior. We …
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Odorant receptors: regulation, signaling, and expression
Olfactory signal transduction is initiated by binding of odorous ligands to G protein-coupled odorant receptors, resulting in the activation of G protein and second messengers that culminates in the generation of action potentials to relay this signal to the brain for odor recognition. This …
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Theoretical and Computational Studies on the Dynamics and Regulation of Cell Phenotypic Transitions
… framework to the differentiation process of olfactory sensory neurons (OSNs), where the observed 'one-neuron-one-allele' phenomenon has remained as a long-standing puzzle. Our model successfully explains this singular behavior in terms of epigenetic competition and enhancer cooperativity …
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Critical Period for Murine Olfactory Map Formation
… Mechanisms regulating the connection between sensory neurons and their central targets during the critical period remain unknown. <br></br><br></br> In this study, together with other members of the Yu lab, I performed a series of experiments in mice to perturb the projection pattern of …
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Connectivity of olfactory bulb dopaminergic interneurons
Olfaction is unique amongst sensory systems because it bypasses the thalamus. Perhaps to compensate for this lack of an intermediate computational hub between periphery and cortex, a vast amount of local processing happens in the olfactory bulb, where the olfactory signal enters the brain. As such, …
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Getting at the Surface: A Promoter and Coding Sequence Characterization of an Odorant Receptor
… receptors (ORs) are expressed by mature olfactory sensory neurons (OSNs), in a monogenic and monoallelic fashion (singular gene choice). It has been repeatedly published that the singular expression of ORs is a consequence of epigenetic regulation. The model invokes the depositing of …
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From Entry to Dysfunction: SARS-CoV-2 Neuropathogenesis in Peripheral Sensory and Autonomic Neurons and Its Implications
… that SARS-CoV-2 infects sustentacular cells and olfactory sensory neurons in the nasal neuroepithelium, enters the olfactory bulb, and spreads throughout the brain. Autopsy studies later suggested that viral entry is also mediated by failure of the blood brain barrier due to inflammation. Missing …
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Employing High Probability Gene Choice Elements to Understand Singular Odorant Receptor Expression
… for odor detection. These detector cells are the olfactory sensory neurons (OSNs), which express odorant receptors (ORs) that bind to chemical odors in the environment. In order to increase specificity and sensitivity, an essential property in olfaction is for each OSN to express an OR in a …
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