Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"olfactory receptor neurons"”.
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Investigation of Age Related Differences in the Rewiring of P2-Olfactory Receptor Neurons
Olfactory receptor neurons (ORNs) maintain the ability to regenerate. These neurons reside in the olfactory epithelium and project axons that connect to the olfactory bulbs. Despite the diffuse distribution of ORNs in the olfactory epithelium, they converge at discrete glomeruli in the olfactory …
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Methyl-CpG-Binding domain proteins and histone deacetylases in the stage-specific differentiation of olfactory receptor neurons
… in the stage-specific differentiation of neurons. In the olfactory epithelium (OE), where neurogenesis is continuous and the cells demonstrate a laminar organization with a developmental hierarchy, we identified sequential, transitional stages of differentiation likely mediated by …
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Starved State Dependent Modulation of Olfactory Receptor Neuron Function in Drosophila melanogaster larvae
The ability of olfactory neurons to locate food sources underlies survival in most species of the animal kingdom. This ability of olfactory neurons to process environmental information is often modulated by the animal's internal state such as hunger. The peripheral end of the olfactory circuit …
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Specific Roles of Kal-1 in Olfaction: A Model of Kallmann Syndrome in Drosophila
… specifically localizes to the dendrites of olfactory receptor neurons (ORNs) throughout development. The dendrites of ORNs sense odorants in the environment including the Drosophila melanogaster male-specific pheromone 11-cis-vaccenyl acetate, which is known to inhibit male-male mating …
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A sexually dimorphic circuit switch in higher olfactory centres
A sexually dimorphic circuit switch in higher olfactory centres In Drosophila the male sex pheromone cis-vaccenyl acetate (cVA) elicits different behaviours in males and females: while males are repelled by cVA, it stimulates female receptivity. However, olfactory receptor neurons and their …
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Analysis of the Molecular Mechanisms of Drosophila Antennal Lobe Development
In Drosophila or mice, the axons of olfactory receptor neurons (ORNs) bearing the same odorant receptor converge on one specific glomerulus in the antennal lobe or olfactory bulb, where they synapse with the dendrites of the postsynaptic cells, projection neurons (PNs) or mitral cells. Mutation in …
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The Roles of Wnt5 and the Drl Receptor in the Development of the Drosophila Olfactory System
During the development of the Drosophila olfactory system, olfactory receptor neurons expressing the same odorant receptors converge their axons precisely onto a specific set of projection neuron dendrites, forming glomeruli in stereotypic positions of the antennal lobe. Although many studies have …
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Two Odorant-Binding Protein Genes in Mosquitoes: Comparative Genomics, Expression, and Function
… lymph and transport them to their cognate receptors in the olfactory receptor neurons. With the availability of the genome sequence of the African malaria mosquito, Anopheles gambiae, there has been a profound interest in the characterization and functional analyses of Obp genes in order to …
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Establishing Neuronal Diversity: Regulation of olfactory receptor neuron specification and axon guidance in Drosophila
<p>The human brain contains over 80 billion neurons that make approximately 100 trillion specific connections. Each neuron must acquire a specific identity that includes its, gene expression, morphology, connectivity, and location. The basic logic and mechanisms that are used to coordinate this …
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Mosquito odor receptor gene targets to alter vector host choice
… Mosquitoes detect semiochemicals through odorant receptors, each of which interact with specific odorants. Differences in feeding behaviors have significant consequences for the vectorial capacity of Anopheles mosquitoes. Mosquitoes in the genus Anopheles vector the pathogens causing human …
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Stochastic dynamics in olfactory signal transduction and development
… be processed by the brain. In the case of the olfactory sense -- the sense of smell -- this is information about the type and concentration of odourants. In the last 15 years major progress has been made in the experimental understanding of the first two stages of the olfactory sense: the …
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Electrophysiological and morphological analyses in two species of insects, Protophormia terraenovae and Ceratitis capitata
… to investigate the complexity of gustative and olfactory systems also thanks to the relative simple organization of their neuronal circuits, as well as the feasibility of the breeding. On the basis of these considerations, aim of my work was to give a contribution on our understanding of …
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Impaired Olfactory Function: Loss of Smell and Insight Into Neurodegenerative Disorders
… to investigate the possible association between olfactory function (‘sense of smell’) impairment in neurodegenerative disorders such as Alzheimer's disease and Parkinson’s disease, through a systematic review of relevant medical academia. Findings were overall consistent among research articles, …
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Diversity of transduction mechanisms in receptor neurons of the main olfactory epithelium in <i>Xenopus laevis</i> tadpoles
Die vorliegende Untersuchung berichtet über Reizantworten olfaktorischer Rezeptorzellen (ORZ) in einer neuartigen Gewebeschnittpräparation des olfaktorischen Epithels von larvalen Xenopus laevis nach Applikation von Aminosäuren und pharmakologischen Wirkstoffen, die den cAMP-vermittelten …